2023
The Plasma Cell Infiltrate Populating the Muscle Tissue of Patients with Inclusion Body Myositis Features Distinct B Cell Receptor Repertoire Properties
Jiang R, Roy B, Wu Q, Mohanty S, Nowak R, Shaw A, Kleinstein S, O’Connor K. The Plasma Cell Infiltrate Populating the Muscle Tissue of Patients with Inclusion Body Myositis Features Distinct B Cell Receptor Repertoire Properties. ImmunoHorizons 2023, 7: 310-322. PMID: 37171806, PMCID: PMC10579972, DOI: 10.4049/immunohorizons.2200078.Peer-Reviewed Original ResearchConceptsInclusion body myositisMemory B cellsCell infiltrateBody myositisB cellsIBM muscle biopsiesB-cell infiltratesPlasma cell infiltrateClass-switched IgGMuscle tissueAdaptive immune receptor repertoire sequencingHumoral responseHealthy controlsIgA isotypePlasma cellsCell repertoireMuscle biopsyInfiltratesDegenerative disordersDisease pathologyRepertoire sequencingSkeletal muscleDermatomyositisPolymyositisMyositis
2017
Motor Neuron Disease
Roy B, Darras B. Motor Neuron Disease. 2017, 199-220. DOI: 10.1007/978-3-319-61361-1_16.Peer-Reviewed Original ResearchNon-5q spinal muscular atrophySpinal muscular atrophyMotor neuronsSurvival motor neuronCompound motor action potential amplitudeProximal 5q SMAMotor action potential amplitudeMotor axon lossAction potential amplitudeMotor neuron diseaseSpinal motor neuronsProgressive muscle weaknessAutosomal recessive disorderHereditary degenerative disordersAxon lossImportant diagnostic toolMuscle weaknessNeuron diseaseClinical severityNeurogenic natureDisease prognosisAtypical casesPotential amplitudeMuscular atrophyDegenerative disorders