2005
Renal cell carcinoma: Current status and future prospects
Drucker BJ. Renal cell carcinoma: Current status and future prospects. Cancer Treatment Reviews 2005, 31: 536-545. PMID: 16236454, DOI: 10.1016/j.ctrv.2005.07.009.Peer-Reviewed Original ResearchConceptsAdvanced renal cell carcinomaRenal cell carcinomaTotal nephrectomyLocalized Renal Cell CarcinomaStandard systemic treatmentSubset of patientsMost patientsSystemic treatmentCurative treatmentRadical nephrectomyPoor prognosisCell carcinomaUnderlying pathophysiologyStandard treatmentRenal tumorsInvasive treatmentNew agentsTumor growthNephrectomyPatientsEarly detectionMolecular pathwaysSurgeryTreatmentDiagnostic methods
2003
Phase II trial of ZD1839 (IRESSA™) in patients with advanced renal cell carcinoma
Drucker B, Bacik J, Ginsberg M, Marion S, Russo P, Mazumdar M, Motzer R. Phase II trial of ZD1839 (IRESSA™) in patients with advanced renal cell carcinoma. Investigational New Drugs 2003, 21: 341-345. PMID: 14578682, DOI: 10.1023/a:1025472712456.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaAdvanced renal cell carcinomaPhase II trialII trialCell carcinomaMemorial Sloan Kettering Cancer Center databaseMetastatic renal cell carcinomaCancer Center databaseProgression of diseaseMonths of startEvaluable patientsMedian TTPPartial responseCell patientsDisease progressionPatientsTreatment efficacyCenter databaseZD1839Antitumor activityProgressionTrialsMonthsFurther studiesCarcinoma