Genomic imprinting of IGF2 in marsupials is methylation dependent
Lawton BR, Carone BR, Obergfell CJ, Ferreri GC, Gondolphi CM, VandeBerg JL, Imumorin I, O'Neill RJ, O'Neill MJ. Genomic imprinting of IGF2 in marsupials is methylation dependent. BMC Genomics 2008, 9: 205. PMID: 18454865, PMCID: PMC2386826, DOI: 10.1186/1471-2164-9-205.Peer-Reviewed Original ResearchConceptsMatrix attachment regionsGenomic imprintingSpecific CpG residuesParent-specific methylationSouth American opossum Monodelphis domesticaAllele-specific patternsMarsupial genomesTranscriptional silencingEvolutionary originImprinted lociImprinted genesSelective forcesCpG residuesEutherian mammalsBiallelic expressionDNA methylationRegulatory featuresCpG methylationKilobase regionOpossum Monodelphis domesticaKey regulatorPaternal Igf2 alleleIgf2 alleleMaternal alleleImprinting mechanism