2022
Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo.
Vageli DP, Doukas PG, Doukas SG, Tsatsakis A, Judson BL. Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo. Cancer Prevention Research 2022, 15: 297-308. PMID: 35502554, DOI: 10.1158/1940-6207.capr-21-0529.Peer-Reviewed Original ResearchConceptsHypopharyngeal squamous cell carcinomaTobacco smoke componentsSquamous cell carcinomaAerodigestive tract carcinogenesisBile refluxRisk factorsHypopharyngeal cancerCell carcinomaChronic exposureNFκB activationVivo modelUpper aerodigestive tract cancerNoxious combinationLarge-scale studiesIndependent risk factorAerodigestive tract cancerUpper aerodigestive tract carcinogenesisHigh-risk individualsVivo chronic exposurePresence of bileSilent progressionTract cancerTobacco smokingInvasive carcinomaPremalignant lesions
2021
Guideline - Adherence in advanced stage head and neck cancer is associated with improved survival – A National study
Cohen O, Brauer PR, Judson BL, Burtness BA, Earles J, Mehra S. Guideline - Adherence in advanced stage head and neck cancer is associated with improved survival – A National study. Oral Oncology 2021, 125: 105694. PMID: 34971883, DOI: 10.1016/j.oraloncology.2021.105694.Peer-Reviewed Original ResearchConceptsOverall survivalNCCN guidelinesGuideline adherenceAdherence ratesNeck cancerAdvanced stage HNCGuideline adherence rateOverall stage IIINational Cancer DatabaseDecreased overall survivalAdvanced-stage headPrevalence of guidelinesComorbidity scoreAdherent patientsAdvanced headClinical stagingImproved survivalGuideline awarenessHNC patientsBlack raceInsurance statusNational cohortCancer DatabaseRisk factorsFemale genderBile reflux and hypopharyngeal cancer
Vageli DP, Doukas SG, Doukas PG, Judson BL. Bile reflux and hypopharyngeal cancer. Oncology Reports 2021, 46: 244. PMID: 34558652, PMCID: PMC8485019, DOI: 10.3892/or.2021.8195.Peer-Reviewed Original ResearchConceptsHypopharyngeal cancerAcidic bileHypopharyngeal carcinogenesisBile refluxRisk factorsGastroesophageal reflux diseaseIndependent risk factorSquamous cell cancerUpper aerodigestive tractElevated p53 expressionAnti-apoptotic effectsReflux diseaseLaryngopharyngeal refluxAerodigestive tractCell cancerGastroesophageal refluxateContribution of STAT3Neck cancerPrecancerous lesionsPremalignant changesNeoplastic changesNF-κBDNA damageP53 expressionBile acidsPepsin Promotes Activation of Epidermal Growth Factor Receptor and Downstream Oncogenic Pathways, at Slightly Acidic and Neutral pH, in Exposed Hypopharyngeal Cells
Doukas PG, Vageli DP, Sasaki CT, Judson BL. Pepsin Promotes Activation of Epidermal Growth Factor Receptor and Downstream Oncogenic Pathways, at Slightly Acidic and Neutral pH, in Exposed Hypopharyngeal Cells. International Journal Of Molecular Sciences 2021, 22: 4275. PMID: 33924087, PMCID: PMC8074291, DOI: 10.3390/ijms22084275.Peer-Reviewed Original ResearchConceptsRelated-signaling pathwaysOncogenic pathwaysLaryngopharyngeal reflux diseaseEpidermal growth factor receptorSpecific oncogenic pathwaysDownstream oncogenic pathwaysGrowth factor receptorHypopharyngeal cellsReflux diseaseRisk factorsTherapeutic approachesIntermittent exposureTumorigenic effectsPronounced activationOncogenic factorSignificant upregulationFactor receptorSTAT3 activationAcidic pepsinEGFR activationCell viabilityPromotes ActivationActivationPrimary cellsCellsA 2020 Update on Public Awareness of Head and Neck Cancers
Torabi SJ, Kasle DA, Su-Velez B, Mehra S, Day TA, Yarbrough WG, St. John M, Judson BL. A 2020 Update on Public Awareness of Head and Neck Cancers. Otolaryngology 2021, 166: 305-312. PMID: 33845657, DOI: 10.1177/01945998211006932.Peer-Reviewed Original ResearchConceptsHuman papillomavirusHPV's roleNeck cancerNeck Cancer Awareness WeekKnowledge of HNCSigns/symptomsFormer tobacco usersCross-sectional surveyFormer smokersOropharyngeal cancerRisk factorsTobacco usersElderly individualsRisk populationsAwareness rateUS populationOlder individualsFuture outreach effortsCancerCausal roleHNCAwareness WeekUS CensusExposureHead
2015
Hospital readmission and 30‐day mortality after surgery for oral cavity cancer: Analysis of 21,681 cases
Luryi AL, Chen MM, Mehra S, Roman SA, Sosa JA, Judson BL. Hospital readmission and 30‐day mortality after surgery for oral cavity cancer: Analysis of 21,681 cases. Head & Neck 2015, 38: e221-e226. PMID: 25537226, DOI: 10.1002/hed.23973.Peer-Reviewed Original ResearchConceptsOral cavity squamous cell cancerSquamous cell cancerNational Cancer Data BaseHospital readmissionHigh-risk patientsUnplanned readmission rateComorbidity indexUnplanned readmissionNeck dissectionReadmission ratesOverall mortalityCell cancerStage T3Male sexRisk factorsRetrospective analysisAge 76Mortality rateReadmissionMortalityPatientsSurgeryT3T4Years
2014
Public Awareness of Head and Neck Cancers: A Cross-Sectional Survey
Luryi AL, Yarbrough WG, Niccolai LM, Roser S, Reed SG, Nathan CA, Moore MG, Day T, Judson BL. Public Awareness of Head and Neck Cancers: A Cross-Sectional Survey. JAMA Otolaryngology - Head & Neck Surgery 2014, 140: 639-646. PMID: 24902640, DOI: 10.1001/jamaoto.2014.867.Peer-Reviewed Original ResearchConceptsRisk factorsThroat cancerHPV infectionNeck cancerDisease burdenTobacco useKnowledge of HNCHuman papillomavirus infectionLifestyle risk factorsKnowledge of signsCross-sectional surveyPapillomavirus infectionSore throatSubstantial morbidityMouth cancerCommon symptomsHuman papillomavirusMAIN OUTCOMEUS adultsBrain cancerSpecific questioningCancerSymptomsEarly detectionInfection
2013
Postdischarge Complications Predict Reoperation and Mortality after Otolaryngologic Surgery
Chen MM, Roman SA, Sosa JA, Judson BL. Postdischarge Complications Predict Reoperation and Mortality after Otolaryngologic Surgery. Otolaryngology 2013, 149: 865-872. PMID: 24047818, DOI: 10.1177/0194599813505078.Peer-Reviewed Original ResearchConceptsPostdischarge complicationsOtolaryngologic surgerySurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramProcedure-specific ratesTongue/floorRetrospective cohort studyVenous thromboembolic eventsHigh-risk patientsRisk of reoperationSurgical site infectionOutcomes of interestQuality Improvement ProgramAnesthesiologists classThromboembolic eventsAdult patientsCohort studySite infectionOperative timePostdischarge eventsRisk factorsReoperationAmerican CollegeSurgery
2012
Role of excision repair cross‐complementation 1 expression as a prognostic marker for response to radiotherapy in early‐stage laryngeal cancer
Johung K, Rewari A, Wu H, Judson B, Contessa JN, Haffty BG, Decker RH. Role of excision repair cross‐complementation 1 expression as a prognostic marker for response to radiotherapy in early‐stage laryngeal cancer. Head & Neck 2012, 35: 852-857. PMID: 22740347, PMCID: PMC5723082, DOI: 10.1002/hed.23041.Peer-Reviewed Original ResearchConceptsERCC1 expressionOverall survivalExcision repair crossLocal controlT classificationLaryngeal cancerEarly-stage laryngeal cancerLaryngeal squamous cell carcinomaClinicopathologic risk factorsHigh ERCC1 expressionPlatinum-based chemotherapySquamous cell carcinomaWorse survivalCell carcinomaPrognostic valueStandard radiotherapyPrognostic markerRisk factorsEffective treatmentImmunohistochemical analysisTissue microarrayStage IRadiotherapy resistanceMultivariate analysisRadiotherapy