2024
Discovering Novel and Unique Saliva and Serum miRNA and mRNA Signatures for Oral Cancer Detection Using Whole Transcriptome and Small Non-Coding RNA Sequencing: Prediction of Their Association With the PI3K/AKT Pathway
Vageli D, Doukas P, Judson B. Discovering Novel and Unique Saliva and Serum miRNA and mRNA Signatures for Oral Cancer Detection Using Whole Transcriptome and Small Non-Coding RNA Sequencing: Prediction of Their Association With the PI3K/AKT Pathway. JCO Global Oncology 2024, 10: 52-52. DOI: 10.1200/go-24-47000.Peer-Reviewed Original ResearchSerum miRNAsPanel of miRNAsHsa-miR-7704Oral squamous cell carcinomaSmall non-coding RNA sequencesHealthy controlsSerum of OSCC patientsMiRNAsMRNA markersOral cavity cancer patientsMRNA signatureDetection of oral cancerOral cavity cancerIdentification of molecular biomarkersSquamous cell carcinomaNon-invasive biomarkersSerum samplesUnique miRNAsOral cancer detectionPost-treatment monitoringCell carcinomaOral cancerNon-coding RNA sequencesOSCC patientsCancer patientsNovel non‐invasive molecular signatures for oral cavity cancer, by whole transcriptome and small non‐coding RNA sequencing analyses: Predicted association with PI3K/AKT/mTOR pathway
Vageli D, Doukas P, Townsend J, Pickering C, Judson B. Novel non‐invasive molecular signatures for oral cavity cancer, by whole transcriptome and small non‐coding RNA sequencing analyses: Predicted association with PI3K/AKT/mTOR pathway. Cancer Medicine 2024, 13: e7309. PMID: 38819439, PMCID: PMC11141334, DOI: 10.1002/cam4.7309.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorCarcinoma, Squamous CellCase-Control StudiesFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMicroRNAsMiddle AgedMouth NeoplasmsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, MessengerRNA, Small UntranslatedSalivaSequence Analysis, RNASignal TransductionTOR Serine-Threonine KinasesTranscriptomeConceptsOral squamous cell carcinomaPost-treatment monitoringHealthy controlsOral cavity cancer patientsOral cavity cancerIdentification of molecular biomarkersSquamous cell carcinomaPatients relative to HCSamples of salivaMonitoring of patientsCell carcinomaPost-treatment monitoring of patientsSmoking historySerum miRNAsCancer patientsEfficient clinical toolEffective preventive careTherapeutic approachesMRNA signatureRNA sequencing analysisClinical testingSerumPatientsMolecular biomarkersClinical tool
2023
Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma
Shah R, Liu C, Shah H, Judson B. Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma. Laryngoscope Investigative Otolaryngology 2023, 8: 870-875. PMID: 37621277, PMCID: PMC10446262, DOI: 10.1002/lio2.1094.Peer-Reviewed Original ResearchOral cavity squamous cell carcinomaAbsolute lymphocyte countOral cavity cancerSquamous cell carcinomaRate of deathLikelihood of recurrenceLymphocyte countPrognostic valueCell carcinomaCancer patientsPreoperative absolute lymphocyte countPretreatment absolute lymphocyte countLate-stage cancer patientsRetrospective chart reviewAmerican Joint CommitteeDay of surgeryEarly-stage cancer patientsTumor registry dataAdjuvant therapyOutcome patientsChart reviewPrimary outcomeALC valuesPositive marginsPrognostic indicator
2018
Changing prognosis of oral cancer: An analysis of survival and treatment between 1973 and 2014
Cheraghlou S, Schettino A, Zogg CK, Judson BL. Changing prognosis of oral cancer: An analysis of survival and treatment between 1973 and 2014. The Laryngoscope 2018, 128: 2762-2769. PMID: 30194691, DOI: 10.1002/lary.27315.Peer-Reviewed Original ResearchConceptsOral cavity cancerLate-stage diseaseAdjuvant therapyOral cancerEnd Results 9 registriesCox survival regressionHigher nodal yieldsNational Cancer DatabaseEarly-stage diseaseKaplan-Meier analysisRetrospective database analysisAnalysis of survivalAdjuvant chemoradiotherapyNodal yieldAdult patientsNeck dissectionRetrospective studyCancer DatabasePrognosisPatientsCancerDiseaseDatabase analysisSurvival regressionChemoradiotherapy
2017
Untreated oral cavity cancer: Long‐term survival and factors associated with treatment refusal
Cheraghlou S, Kuo P, Mehra S, Yarbrough WG, Judson BL. Untreated oral cavity cancer: Long‐term survival and factors associated with treatment refusal. The Laryngoscope 2017, 128: 664-669. PMID: 28865100, DOI: 10.1002/lary.26809.Peer-Reviewed Original ResearchConceptsOral cavity cancerNatural courseTreatment refusalUnivariate Kaplan-Meier analysisFive-year survival rateFacility case volumeNational Cancer DatabaseStage 4 patientsExtent of diseaseMultivariate Cox regressionEarly-stage patientsKaplan-Meier analysisNumber of patientsCommon malignant diseaseLong-term survivalInitial treatment planningAdvanced diseaseUntreated patientsAdult patientsRetrospective reviewCox regressionPatient's likelihoodPoor prognosisInsurance statusMalignant diseaseTreatment guidelines and patterns of care in oral cavity squamous cell carcinoma: Primary surgical resection vs. nonsurgical treatment
Fujiwara RJT, Burtness B, Husain ZA, Judson BL, Bhatia A, Sasaki CT, Yarbrough WG, Mehra S. Treatment guidelines and patterns of care in oral cavity squamous cell carcinoma: Primary surgical resection vs. nonsurgical treatment. Oral Oncology 2017, 71: 129-137. PMID: 28688680, DOI: 10.1016/j.oraloncology.2017.06.013.Peer-Reviewed Original ResearchConceptsOral cavity squamous cell carcinomaNational Cancer Data BaseLate-stage diseasePrimary nonsurgical treatmentOral cavity malignancyNonsurgical treatmentSquamous cell carcinomaOverall survivalSurgical resectionCell carcinomaTreatment modalitiesNational Comprehensive Cancer Network Clinical Practice GuidelinesAcademic/research programMultimodality clinical trialsDefinitive radiation therapyImproved overall survivalDecreased overall survivalPrimary surgical resectionOral cavity cancerNon-randomized natureClinical practice guidelinesPatterns of careNon-white raceProportional hazards modelBinary logistic regression
2016
Proposing prognostic thresholds for lymph node yield in clinically lymph node‐negative and lymph node‐positive cancers of the oral cavity
Kuo P, Mehra S, Sosa JA, Roman SA, Husain ZA, Burtness BA, Tate JP, Yarbrough WG, Judson BL. Proposing prognostic thresholds for lymph node yield in clinically lymph node‐negative and lymph node‐positive cancers of the oral cavity. Cancer 2016, 122: 3624-3631. PMID: 27479645, DOI: 10.1002/cncr.30227.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseOral cavity cancerMortality hazard ratioLymph nodesHazard ratioNeck dissectionLymph node-negative cancersLymph node-positive cancersNode-positive cancersNode-positive cohortPositive lymph nodesTherapeutic neck dissectionEnd Results (SEER) databaseLymph node yieldHigh-volume centersExtensive neck dissectionMultiple cancer sitesNode-negative cancersOverall survivalHigher lymphPrognostic factorsTreatment guidelinesNode yieldResults databaseSurgical management
2015
Treatment Factors Associated With Survival in Early-Stage Oral Cavity Cancer: Analysis of 6830 Cases From the National Cancer Data Base
Luryi AL, Chen MM, Mehra S, Roman SA, Sosa JA, Judson BL. Treatment Factors Associated With Survival in Early-Stage Oral Cavity Cancer: Analysis of 6830 Cases From the National Cancer Data Base. JAMA Otolaryngology - Head & Neck Surgery 2015, 141: 593-598. PMID: 25974757, DOI: 10.1001/jamaoto.2015.0719.Peer-Reviewed Original ResearchConceptsOral cavity squamous cell cancerNational Cancer Data BaseNeck dissectionOverall survivalImproved survivalRadiation therapyTreatment factorsMultivariable analysisPositive marginsStage IEarly-stage oral cavity cancerOral cavity squamous cell carcinomaElimination of patientsTumor prognostic featuresAdjuvant radiation therapyOccult nodal diseaseOral cavity cancerSquamous cell cancerSquamous cell carcinomaPopulation-level dataAdjuvant chemotherapyPathologic restagingNodal diseaseMost patientsPrognostic impactComplications and mortality following surgery for oral cavity cancer: Analysis of 408 cases
Schwam ZG, Sosa JA, Roman S, Judson BL. Complications and mortality following surgery for oral cavity cancer: Analysis of 408 cases. The Laryngoscope 2015, 125: 1869-1873. PMID: 26063059, DOI: 10.1002/lary.25328.Peer-Reviewed Original ResearchConceptsOral cavity cancerPostdischarge complicationsPostoperative complicationsNeck dissectionNational Surgical Quality Improvement Program Participant Use Data FilesSurgeons National Surgical Quality Improvement Program Participant Use Data FilesSurgical siteDay 14Oral cavity cancer surgeryParticipant Use Data FilePostdischarge surgical-site infectionsCommon adverse eventsRetrospective cohort studySurgical site complicationsHigh-risk patientsModifiable risk factorsSurgical site infectionDisease-specific complicationsMultivariate regression analysisRespiratory complicationsAdverse eventsCohort studyCurrent smokersSite complicationsCancer surgery
2014
Positive Surgical Margins in Early Stage Oral Cavity Cancer: An Analysis of 20,602 Cases
Luryi AL, Chen MM, Mehra S, Roman SA, Sosa JA, Judson BL. Positive Surgical Margins in Early Stage Oral Cavity Cancer: An Analysis of 20,602 Cases. Otolaryngology 2014, 151: 984-990. PMID: 25257901, DOI: 10.1177/0194599814551718.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnalysis of VarianceCarcinoma, Squamous CellConfidence IntervalsDatabases, FactualDisease-Free SurvivalFemaleHumansMaleMiddle AgedMouth NeoplasmsMultivariate AnalysisNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingOral Surgical ProceduresPrognosisRetrospective StudiesRisk AssessmentSurvival AnalysisTreatment OutcomeConceptsOral cavity cancerEarly oral cavity cancerPositive surgical marginsPositive marginsMargin statusSurgical marginsCase volumeEarly-stage oral cavity cancerOral cavity squamous cell cancerDifficulty of resectionNational Cancer DatabaseStage II diseaseEarly oral cancerHospital case volumeSquamous cell cancerTreatment facility typeFloor of mouthQuality of careUseful quality measureTumor factorsClinical factorsCell cancerCancer CenterOral cancerCancer Database