2021
Neuroinvasion of SARS-CoV-2 in human and mouse brain
Song E, Zhang C, Israelow B, Lu-Culligan A, Prado AV, Skriabine S, Lu P, Weizman OE, Liu F, Dai Y, Szigeti-Buck K, Yasumoto Y, Wang G, Castaldi C, Heltke J, Ng E, Wheeler J, Alfajaro MM, Levavasseur E, Fontes B, Ravindra NG, Van Dijk D, Mane S, Gunel M, Ring A, Kazmi SAJ, Zhang K, Wilen CB, Horvath TL, Plu I, Haik S, Thomas JL, Louvi A, Farhadian SF, Huttner A, Seilhean D, Renier N, Bilguvar K, Iwasaki A. Neuroinvasion of SARS-CoV-2 in human and mouse brain. Journal Of Experimental Medicine 2021, 218: e20202135. PMID: 33433624, PMCID: PMC7808299, DOI: 10.1084/jem.20202135.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Central nervous systemSARS-CoV-2 neuroinvasionImmune cell infiltratesCOVID-19 patientsType I interferon responseMultiple organ systemsCOVID-19I interferon responseHuman brain organoidsNeuroinvasive capacityCNS infectionsCell infiltrateNeuronal infectionPathological featuresCortical neuronsRespiratory diseaseDirect infectionCerebrospinal fluidNervous systemMouse brainInterferon responseOrgan systemsHuman ACE2Infection
2013
Temporal Analysis of Hepatitis C Virus Cell Entry with Occludin Directed Blocking Antibodies
Sourisseau M, Michta ML, Zony C, Israelow B, Hopcraft SE, Narbus CM, Martín A, Evans MJ. Temporal Analysis of Hepatitis C Virus Cell Entry with Occludin Directed Blocking Antibodies. PLOS Pathogens 2013, 9: e1003244. PMID: 23555257, PMCID: PMC3605286, DOI: 10.1371/journal.ppat.1003244.Peer-Reviewed Original ResearchConceptsHCV cell entryHepatitis C virusClaudin-1Complete HCV life cycleCell entryTight junction protein claudin-1HCV life cyclePost-binding stageMiR-122 expressionHepatitis C virus cell entryHepG2 cellsNumerous host factorsVirus cell entryHCV therapyLiver diseaseC virusInfection assaysBlocking antibodiesHCV isolatesSR-BIHost cell entryHost factorsUtilization differencesMajor causeOccludin