Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording.
Grace A, Bunney B. Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording. Journal Of Pharmacology And Experimental Therapeutics 1986, 238: 1092-100. PMID: 3746660.Peer-Reviewed Original ResearchConceptsAdministration of haloperidolDopamine neuronsVivo intracellular recordingsDepolarization blockIntracellular recordingsNigral dopamine neuronsAdministration of neurolepticsActive dopamine neuronsSpontaneous spike activityDopamine agonist apomorphineAntipsychotic drug haloperidolSpontaneous electrophysiological activityMidbrain dopamine neuronsAcute administrationAgonist apomorphineSubstantia nigraControl ratsExcitatory driveDepolarization blockadeDrug haloperidolSpontaneous activitySpike activityFiring rateHaloperidolNeurons