Cellular softening mediates leukocyte demargination and trafficking, thereby increasing clinical blood counts
Fay ME, Myers DR, Kumar A, Turbyfield CT, Byler R, Crawford K, Mannino RG, Laohapant A, Tyburski EA, Sakurai Y, Rosenbluth MJ, Switz NA, Sulchek TA, Graham MD, Lam WA. Cellular softening mediates leukocyte demargination and trafficking, thereby increasing clinical blood counts. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 1987-1992. PMID: 26858400, PMCID: PMC4776450, DOI: 10.1073/pnas.1508920113.Peer-Reviewed Original ResearchMeSH KeywordsCatecholaminesCell MovementFemaleGlucocorticoidsGranulocytesHumansLab-On-A-Chip DevicesLeukocyte CountMaleModels, CardiovascularConceptsHematopoietic stem cell mobilizationEffects of glucocorticoidsStem cell mobilizationWhite blood cellsHealthy human subjectsInnate immune systemProportion of granulocytesCatecholamine exposureBlood countGranulocyte countInflammatory processCell mobilizationLeukocyte traffickingDemarginationVascular wallImmune systemLeukocyte stiffnessGlucocorticoidsCatecholamine hormonesBlood cellsCapillary bedHuman subjectsUnderlying mechanismLarge vesselsCount