1997
Gene Regulation by Mechanical Forces
Oluwole BO, Du W, Mills I, Sumpio BE. Gene Regulation by Mechanical Forces. Endothelium 1997, 5: 85-93. PMID: 9237042, DOI: 10.3109/10623329709079866.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCattleCell Adhesion MoleculesCell Culture TechniquesCells, CulturedEndothelinsEndothelium, VascularEpoprostenolFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesGene Expression RegulationHemorheologyHumansMechanoreceptorsMembranes, ArtificialNitric OxideProtein-Tyrosine KinasesSignal TransductionStress, MechanicalTissue Plasminogen ActivatorTranscription FactorsTranscription, GeneticVacuumConceptsEndothelial cellsEndothelial cell functionCyclic strainVasoactive mediatorsSecond messenger cascadesNitric oxideBlood vesselsMechanical forcesCell functionMechanical deformationFlow of bloodMessenger cascadesLuminal surfaceSpecific response elementsPromoter geneResponse elementExternal forcesMediatorsCytoskeletal changesCellsForceProstacyclinExpressionTranscription levels
1993
Enhanced Patency of Venous Dacron Grafts by Endothelial Cell Sodding
Wang Z, Li G, Wu J, Du W, Pu L, Zhang H, Wang D, Sumpio B. Enhanced Patency of Venous Dacron Grafts by Endothelial Cell Sodding. Annals Of Vascular Surgery 1993, 7: 429-436. PMID: 8268088, DOI: 10.1007/bf02002126.Peer-Reviewed Original ResearchConceptsInferior vena cavaDacron graftEndothelial cell soddingVena cavaLess thromboxane A2Production of prostacyclinCanine inferior vena cavaPatency ratesThromboxane A2Neointimal thickeningControl graftsGraftPatencyGraft surfaceCavaProstacyclinDensity gradient centrifugationCanine omentumSignificant improvementConfluent layerGradient centrifugationOmentumA2Rapid endothelializationNeointima