Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Heart Association
Alexander B, South A, August P, Bertagnolli M, Ferranti E, Grobe J, Jones E, Loria A, Safdar B, Sequeira-Lopez M, Health O. Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Heart Association. Hypertension 2023, 80: e75-e89. PMID: 36951054, PMCID: PMC10242542, DOI: 10.1161/hyp.0000000000000227.Peer-Reviewed Original ResearchConceptsAldosterone systemCardiovascular healthCardiovascular diseaseLong-term cardiovascular healthAntenatal risk factorsRisk of hypertensionAdverse cardiovascular healthAmerican Heart AssociationMaternal-fetal healthTranslational research studiesPregnancy complicationsRenin-AngiotensinPreclinical evidenceComplicated pregnanciesPlacental interfaceHeart AssociationRisk factorsSystem dysregulationNovel therapiesClinical careRisk individualsHealth outcomesLife courseDiseaseScientific evidence