Xanthine oxidase, nitric oxide synthase and phospholipase A2 produce reactive oxygen species via mitochondria
Sanganahalli B, Joshi P, Joshi N. Xanthine oxidase, nitric oxide synthase and phospholipase A2 produce reactive oxygen species via mitochondria. Brain Research 2005, 1037: 200-203. PMID: 15777770, DOI: 10.1016/j.brainres.2005.01.013.Peer-Reviewed Original ResearchConceptsMitochondrial depolarizationReactive oxygen speciesReactive oxygen species formationROS formationGlutamate-induced oxidative stressOxygen speciesDepolarized mitochondriaCytoplasmic enzymeFormation of reactive oxygen speciesNitric oxide synthaseRat cortical slicesL-NAMEMitochondriaPhospholipase A(2Presence of allopurinolSpeciesEnzymeAssociated with excitotoxicityCortical slicesPLA(2PhospholipasePhospholipase A2Xanthine oxidaseSynthaseOxidative stress