The RNA-dependent association of phosphatidylinositol 4,5-bisphosphate with intrinsically disordered proteins contribute to nuclear compartmentalization.
Sztacho M, Červenka J, Šalovská B, Antiga L, Hoboth P, Hozák P. The RNA-dependent association of phosphatidylinositol 4,5-bisphosphate with intrinsically disordered proteins contribute to nuclear compartmentalization. PLOS Genetics 2024, 20: e1011462. PMID: 39621780, DOI: 10.1371/journal.pgen.1011462.Peer-Reviewed Original ResearchPhosphatidylinositol 4,5-bisphosphateBromodomain-containing protein 4Nuclear specklesNuclear architectureRNA-dependent associationRNA-dependent mannerAssociated with RNAFunctional nuclear architectureRNA-dependentUbiquitination sitesNuclear compartmentalizationNuclear localizationNuclear fociNuclear compartmentDisordered proteinsPIP2 levelsDisordered regionsGene expressionHuman cellsPIP2RNANuclear processesBRD4 proteinProteinRNA content