2021
Association of Epigenetic Age Acceleration With Risk Factors, Survival, and Quality of Life in Patients With Head and Neck Cancer
Xiao C, Miller AH, Peng G, Levine ME, Conneely KN, Zhao H, Eldridge RC, Wommack EC, Jeon S, Higgins KA, Shin DM, Saba NF, Smith AK, Burtness B, Park HS, Irwin ML, Ferrucci LM, Ulrich B, Qian DC, Beitler JJ, Bruner DW. Association of Epigenetic Age Acceleration With Risk Factors, Survival, and Quality of Life in Patients With Head and Neck Cancer. International Journal Of Radiation Oncology • Biology • Physics 2021, 111: 157-167. PMID: 33882281, PMCID: PMC8802868, DOI: 10.1016/j.ijrobp.2021.04.002.Peer-Reviewed Original ResearchConceptsProgression-free survivalBody mass indexQuality of lifeHigher epigenetic age accelerationTreatment-related symptomsOverall survivalEpigenetic age accelerationRadiation therapyRisk factorsClinical characteristicsNeck cancerAge accelerationWorse overall survivalHuman papilloma virusFaster biological agingAdverse eventsDistant metastasisLifestyle factorsMass indexCancer outcomesBlood biomarkersPapilloma virusFunctional assessmentHigher HRPatients
2014
p16 status, pathologic and clinical characteristics, biomolecular signature, and long‐term outcomes in head and neck squamous cell carcinomas of unknown primary
Keller LM, Galloway TJ, Holdbrook T, Ruth K, Yang D, Dubyk C, Flieder D, Lango MN, Mehra R, Burtness B, Ridge JA. p16 status, pathologic and clinical characteristics, biomolecular signature, and long‐term outcomes in head and neck squamous cell carcinomas of unknown primary. Head & Neck 2014, 36: 1677-1684. PMID: 24115269, PMCID: PMC3972378, DOI: 10.1002/hed.23514.Peer-Reviewed Original ResearchConceptsSquamous cell CUPNeck squamous cell carcinomaSquamous cell carcinomaUnknown primaryCell carcinomaTissue microarrayOverall survivalP16 statusHuman papillomavirus (HPV) statusMajority of patientsWorse overall survivalLong-term outcomesHPV associationP16 stainClinical characteristicsClinicopathologic characteristicsPrognostic factorsPrognostic featuresPrognostic implicationsExtracapsular extensionP16 stainingYounger ageCarcinomaP16High grade
2012
p16 Status, Pathologic and Clinical Characteristics, and Long-term Outcomes in Unknown Primary Carcinomas of the Head and Neck
Keller L, Galloway T, Holdbrook T, Flieder D, Ruth K, Lango M, Mehra R, Burtness B, Ridge J. p16 Status, Pathologic and Clinical Characteristics, and Long-term Outcomes in Unknown Primary Carcinomas of the Head and Neck. International Journal Of Radiation Oncology • Biology • Physics 2012, 84: s514. DOI: 10.1016/j.ijrobp.2012.07.1370.Peer-Reviewed Original ResearchUnknown primary carcinomaLong-term outcomesClinical characteristicsPrimary carcinomaP16 statusCarcinomaPathologicNeck