2023
Role of homeobox d10 gene targeted signaling pathways in cancers
Surendran H, Palaniyandi T, Natarajan S, Hari R, Viwanathan S, Baskar G, Abdul Wahab M, Ravi M, Rajendran B. Role of homeobox d10 gene targeted signaling pathways in cancers. Pathology - Research And Practice 2023, 248: 154643. PMID: 37406379, DOI: 10.1016/j.prp.2023.154643.Peer-Reviewed Original ResearchConceptsTranscription factorsHomeobox gene familyHomeotic transcription factorsGene expression changesTumor suppressor geneD10 geneGene familyHomeobox genesCancer signalingOrgan developmentTissue homeostasisGene expressionExpression changesSignaling pathwaysCell differentiationSuppressor geneFunctional interactionGenesHOXD10 geneCancer treatment targetHOXD10Pathway dysregulationTherapeutic resistancePathwayMolecule actionIntegrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations
Ren J, Qu R, Rahman N, Lewis J, King A, Liao X, Mirza F, Carlson K, Huang Y, Gigante S, Evans B, Rajendran B, Xu S, Wang G, Foss F, Damsky W, Kluger Y, Krishnaswamy S, Girardi M. Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations. Blood Advances 2023, 7: 445-457. PMID: 35947128, PMCID: PMC9979716, DOI: 10.1182/bloodadvances.2022008168.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaMalignant CTCL cellsDiverse transcriptomic profilesT cellsSingle-cell RNACTCL cellsDevelopment of CTCLIntegrated transcriptomeT-cell receptor sequencingT cell exhaustion phenotypeCommon antigenic stimulusPeripheral blood CD4Transcriptomic profilesGene expressionT-cell lymphomaIntegrative analysisPotential therapeutic targetProliferation advantageLimited diversityBlood CD4Blood involvementMutation levelsExhaustion phenotypeWorse prognosisAntigenic stimulus
2022
Gene expressions and their significance in organoid cultures obtained from breast cancer patient-derived biopsies
Pranav P, Palaniyandi T, Baskar G, Ravi M, Rajendran B, Sivaji A, Ranganathan M. Gene expressions and their significance in organoid cultures obtained from breast cancer patient-derived biopsies. Acta Histochemica 2022, 124: 151910. PMID: 35667159, DOI: 10.1016/j.acthis.2022.151910.Peer-Reviewed Original ResearchConceptsBreast cancerOrganoid culturesGene expression changesPatient-derived biopsiesBreast cancer biopsiesExpression of ErbB2Progesterone receptor geneCancer cell linesExpression changesSuch cancersPatient biopsiesCancer biopsiesSolid tumorsBiopsyMalignant cellsCancerGene expressionMagnitude of expressionHuman cancersCancer therapyReceptor geneCell linesSuch organoidsCancer researchFunctional physiology
2017
comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis
Rajendran B, Deng C. comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis. Oncotarget 2017, 5: 102263-102276. PMID: 29254242, PMCID: PMC5731952, DOI: 10.18632/oncotarget.20404.Peer-Reviewed Original ResearchCopy number alterationsBreast tumorigenesisNumber alterationsGenetic network analysisPrognostic molecular signaturesCancer-associated genesCellular functionsOBSCN geneMultifunctional proteinBreast cancer progressionMyofibril organizationClinical breast cancer samplesGene expressionIntegrative analysisFunctional mutationsDownstream pathwaysExpression dataGenesCell adhesionMolecular signaturesCancer progressionGene methylationDirect roleTumorigenesisObscurin