2010
Rhinovirus Infection of Allergen-Sensitized and -Challenged Mice Induces Eotaxin Release from Functionally Polarized Macrophages
Nagarkar DR, Bowman ER, Schneider D, Wang Q, Shim J, Zhao Y, Linn MJ, McHenry CL, Gosangi B, Bentley JK, Tsai WC, Sajjan US, Lukacs NW, Hershenson MB. Rhinovirus Infection of Allergen-Sensitized and -Challenged Mice Induces Eotaxin Release from Functionally Polarized Macrophages. The Journal Of Immunology 2010, 185: 2525-2535. PMID: 20644177, PMCID: PMC3208235, DOI: 10.4049/jimmunol.1000286.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBronchial HyperreactivityChemokine CCL11CytokinesEosinophilsHeLa CellsHumansImmunohistochemistryInflammationInflammation MediatorsLungMacrophages, AlveolarMiceMice, Inbred BALB CMicroscopy, ConfocalOvalbuminPicornaviridae InfectionsReverse Transcriptase Polymerase Chain ReactionRhinovirusConceptsAllergic airway diseaseEotaxin-1Asthma exacerbationsAirway diseaseIL-4Eosinophilic inflammationRhinovirus infectionRV infectionLung macrophagesVirus-induced asthma exacerbationsBALB/c miceEotaxin-1/CCL11Airway eosinophilic inflammationRV-infected miceIL-4 productionVirus-infected miceHuman rhinovirus infectionDepletion of macrophagesCD68-positive cellsMacrophage activation statusRhinovirus serotype 1BAirway responsivenessCholinergic hyperresponsivenessRV inoculationAirway eosinophilia
2009
Exercise-Training in Young Drosophila melanogaster Reduces Age-Related Decline in Mobility and Cardiac Performance
Piazza N, Gosangi B, Devilla S, Arking R, Wessells R. Exercise-Training in Young Drosophila melanogaster Reduces Age-Related Decline in Mobility and Cardiac Performance. PLOS ONE 2009, 4: e5886. PMID: 19517023, PMCID: PMC2691613, DOI: 10.1371/journal.pone.0005886.Peer-Reviewed Original ResearchConceptsInvertebrate genetic model systemGenetic model systemUnbiased genetic screenGenetic screenDrosophila melanogasterGenetic basisYoung fliesMitochondrial efficiencyAmount of proteinFliesExercise training modelPhysiological responsesModel systemGenetic therapiesMelanogasterMechanized platformNegative geotaxisLociProteinPhenotypeResponseGreat promiseLipidsAge-related declineMajor source