2010
Rhinovirus Infection of Allergen-Sensitized and -Challenged Mice Induces Eotaxin Release from Functionally Polarized Macrophages
Nagarkar DR, Bowman ER, Schneider D, Wang Q, Shim J, Zhao Y, Linn MJ, McHenry CL, Gosangi B, Bentley JK, Tsai WC, Sajjan US, Lukacs NW, Hershenson MB. Rhinovirus Infection of Allergen-Sensitized and -Challenged Mice Induces Eotaxin Release from Functionally Polarized Macrophages. The Journal Of Immunology 2010, 185: 2525-2535. PMID: 20644177, PMCID: PMC3208235, DOI: 10.4049/jimmunol.1000286.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBronchial HyperreactivityChemokine CCL11CytokinesEosinophilsHeLa CellsHumansImmunohistochemistryInflammationInflammation MediatorsLungMacrophages, AlveolarMiceMice, Inbred BALB CMicroscopy, ConfocalOvalbuminPicornaviridae InfectionsReverse Transcriptase Polymerase Chain ReactionRhinovirusConceptsAllergic airway diseaseEotaxin-1Asthma exacerbationsAirway diseaseIL-4Eosinophilic inflammationRhinovirus infectionRV infectionLung macrophagesVirus-induced asthma exacerbationsBALB/c miceEotaxin-1/CCL11Airway eosinophilic inflammationRV-infected miceIL-4 productionVirus-infected miceHuman rhinovirus infectionDepletion of macrophagesCD68-positive cellsMacrophage activation statusRhinovirus serotype 1BAirway responsivenessCholinergic hyperresponsivenessRV inoculationAirway eosinophilia
2009
Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses
Wang Q, Nagarkar DR, Bowman ER, Schneider D, Gosangi B, Lei J, Zhao Y, McHenry CL, Burgens RV, Miller DJ, Sajjan U, Hershenson MB. Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses. The Journal Of Immunology 2009, 183: 6989-6997. PMID: 19890046, PMCID: PMC2920602, DOI: 10.4049/jimmunol.0901386.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternCell LineDEAD Box Protein 58DEAD-box RNA HelicasesEpithelial CellsGene ExpressionHumansInterferon-Induced Helicase, IFIH1Picornaviridae InfectionsReceptors, ImmunologicReceptors, Pattern RecognitionRespiratory MucosaReverse Transcriptase Polymerase Chain ReactionRhinovirusRNA, Double-StrandedRNA, Small InterferingSignal TransductionToll-Like Receptor 3ConceptsIL-8/CXCL8RV-1BChronic obstructive pulmonary disease exacerbationsObstructive pulmonary disease exacerbationsGM-CSFMelanoma differentiation-associated geneAirway epithelial cell responsesIFN-lambda1Pulmonary disease exacerbationsBEAS-2B human bronchial epithelial cellsRetinoic acid-inducible geneToll/IL-1RHuman bronchial epithelial cellsPattern recognition receptorsEpithelial cell responsesUV-irradiated virusBronchial epithelial cellsAcid-inducible geneBEAS-2B cellsDisease exacerbationTLR-3IFN response factorsCommon coldIL-1RIFN expression