Rhinovirus Infection of Allergen-Sensitized and -Challenged Mice Induces Eotaxin Release from Functionally Polarized Macrophages
Nagarkar DR, Bowman ER, Schneider D, Wang Q, Shim J, Zhao Y, Linn MJ, McHenry CL, Gosangi B, Bentley JK, Tsai WC, Sajjan US, Lukacs NW, Hershenson MB. Rhinovirus Infection of Allergen-Sensitized and -Challenged Mice Induces Eotaxin Release from Functionally Polarized Macrophages. The Journal Of Immunology 2010, 185: 2525-2535. PMID: 20644177, PMCID: PMC3208235, DOI: 10.4049/jimmunol.1000286.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBronchial HyperreactivityChemokine CCL11CytokinesEosinophilsHeLa CellsHumansImmunohistochemistryInflammationInflammation MediatorsLungMacrophages, AlveolarMiceMice, Inbred BALB CMicroscopy, ConfocalOvalbuminPicornaviridae InfectionsReverse Transcriptase Polymerase Chain ReactionRhinovirusConceptsAllergic airway diseaseEotaxin-1Asthma exacerbationsAirway diseaseIL-4Eosinophilic inflammationRhinovirus infectionRV infectionLung macrophagesVirus-induced asthma exacerbationsBALB/c miceEotaxin-1/CCL11Airway eosinophilic inflammationRV-infected miceIL-4 productionVirus-infected miceHuman rhinovirus infectionDepletion of macrophagesCD68-positive cellsMacrophage activation statusRhinovirus serotype 1BAirway responsivenessCholinergic hyperresponsivenessRV inoculationAirway eosinophilia