2020
Location and function of transient receptor potential canonical channel 1 in ventricular myocytes
Hu Q, Ahmad A, Seidel T, Hunter C, Streiff M, Nikolova L, Spitzer K, Sachse F. Location and function of transient receptor potential canonical channel 1 in ventricular myocytes. Journal Of Molecular And Cellular Cardiology 2020, 139: 113-123. PMID: 31982426, PMCID: PMC7085981, DOI: 10.1016/j.yjmcc.2020.01.008.Peer-Reviewed Original ResearchConceptsNeonatal rat ventricular myocytesRabbit ventricular myocytesVentricular myocytesSarcoplasmic reticulumChannel blocker SKF-96365TRPC1 overexpressionTransient receptor potential canonical channel 1Physiological pacing ratesTRPC1 channelsAdult rabbit ventricular myocytesRole of TRPC1Rat ventricular myocytesSarco/endoplasmic reticulum CaTransient receptor potentialMammalian ventricular myocytesIsolated rabbit cardiomyocytesEndoplasmic reticulum CaSKF-96365Free solutionCardiac hypertrophyPacing rateAction potentialsTRPC channelsTransverse tubular systemReticulum Ca
2017
Physiological and pathophysiological role of transient receptor potential canonical channels in cardiac myocytes
Ahmad A, Streiff M, Hunter C, Hu Q, Sachse F. Physiological and pathophysiological role of transient receptor potential canonical channels in cardiac myocytes. Progress In Biophysics And Molecular Biology 2017, 130: 254-263. PMID: 28629808, DOI: 10.1016/j.pbiomolbio.2017.06.005.Peer-Reviewed Original ResearchConceptsTransient receptor potential canonical (TRPC) channelsTRPC channelsCanonical channelsHypertrophic signalingCardiac pathophysiologyPhysiological rolePermeable ion channelsNon-cardiac cellsPathophysiological roleCardiac diseaseHeart rateTopic of controversyTRPC activityPharmacological toolsSuggested physiological rolesCardiac physiologyCardiac myocytesMammalian heartCardiac cellsPathophysiologyPrecise roleTRPC1HeartIon channelsCell typesSheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading
Seidel T, Navankasattusas S, Ahmad A, Diakos N, Xu W, Tristani-Firouzi M, Bonios M, Taleb I, Li D, Selzman C, Drakos S, Sachse F. Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading. Circulation 2017, 135: 1632-1645. PMID: 28073805, PMCID: PMC5404964, DOI: 10.1161/circulationaha.116.024470.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiopsyCase-Control StudiesEchocardiographyExcitation Contraction CouplingFemaleHeart FailureHeart-Assist DevicesHumansImage Processing, Computer-AssistedMaleMicroscopy, ConfocalMiddle AgedMyocardial ContractionMyocytes, CardiacProspective StudiesProsthesis DesignRecovery of FunctionRyanodine Receptor Calcium Release ChannelTime FactorsTreatment OutcomeVentricular Function, LeftVentricular RemodelingConceptsLeft ventricular assist deviceChronic heart failureHeart failureExcitation-contraction couplingCardiac recoveryMechanical unloadingLVAD implantationEjection fractionFunctional recoveryHF myocytesImplantation of LVADHallmark of HFHuman end-stage heart failureLeft ventricular ejection fractionEnd-stage heart failureTransverse tubular systemEnd-stage human heart failureEjection fraction increaseIsolated human cardiomyocytesVentricular ejection fractionSubgroup of patientsVolume/length ratioHuman heart failureFunctional cardiac recoveryVentricular assist device