2022
TRPC1 channels underlie stretch-modulated sarcoplasmic reticulum calcium leak in cardiomyocytes
Streiff M, Corbin A, Ahmad A, Hunter C, Sachse F. TRPC1 channels underlie stretch-modulated sarcoplasmic reticulum calcium leak in cardiomyocytes. Frontiers In Physiology 2022, 13: 1056657. PMID: 36620209, PMCID: PMC9817106, DOI: 10.3389/fphys.2022.1056657.Peer-Reviewed Original ResearchNeonatal rat ventricular myocytesTransient receptor potentialTRPC1 channelsTRPC1 expressionCardiac diseaseReceptor potentialSarcoplasmic reticulum calcium leakAdenoviral transfectionRat ventricular myocytesSarco/endoplasmic reticulum CaPermeable ion channelsPhysiological roleSR leakPharmacological therapyEndoplasmic reticulum CaCalcium leakMechanosensitive modulationVentricular myocytesWestern blotReticulum CaRT-qPCRTRPC1CardiomyocytesDisease developmentSignificant reduction
2017
Physiological and pathophysiological role of transient receptor potential canonical channels in cardiac myocytes
Ahmad A, Streiff M, Hunter C, Hu Q, Sachse F. Physiological and pathophysiological role of transient receptor potential canonical channels in cardiac myocytes. Progress In Biophysics And Molecular Biology 2017, 130: 254-263. PMID: 28629808, DOI: 10.1016/j.pbiomolbio.2017.06.005.Peer-Reviewed Original ResearchConceptsTransient receptor potential canonical (TRPC) channelsTRPC channelsCanonical channelsHypertrophic signalingCardiac pathophysiologyPhysiological rolePermeable ion channelsNon-cardiac cellsPathophysiological roleCardiac diseaseHeart rateTopic of controversyTRPC activityPharmacological toolsSuggested physiological rolesCardiac physiologyCardiac myocytesMammalian heartCardiac cellsPathophysiologyPrecise roleTRPC1HeartIon channelsCell types