2008
Regulation and activation of ezrin protein in endometriosis
Ornek T, Fadiel A, Tan O, Naftolin F, Arici A. Regulation and activation of ezrin protein in endometriosis. Human Reproduction 2008, 23: 2104-2112. PMID: 18552365, DOI: 10.1093/humrep/den215.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsEctopic endometrial tissuePathogenesis of endometriosisWestern blot analysisEndometrial tissueNormal endometriumEctopic endometrial stromal cellsNormal endometrial stromal cellsEctopic endometrial tissue samplesEndometrial tissue samplesEzrin proteinMembrane invasionBlot analysisExpression of ezrinEndometriosisStromal cellsEutopicPotential markerTissue samplesWomenInvasive characteristicsCell invasionEctopic sitesEndometriumInvasive potential
2004
Regulation of Interleukin-8 Expression in Human Endometrial Endothelial Cells: A Potential Mechanism for the Pathogenesis of Endometriosis
Luk J, Seval Y, Kayisli UA, Ulukus M, Ulukus CE, Arici A. Regulation of Interleukin-8 Expression in Human Endometrial Endothelial Cells: A Potential Mechanism for the Pathogenesis of Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 1805-1811. PMID: 15613411, DOI: 10.1210/jc.2004-1813.Peer-Reviewed Original ResearchConceptsHuman endometrial endothelial cellsIL-8 mRNAEndometrial endothelial cellsIL-8 expressionSex steroidsEndothelial cellsEutopic endometriumCultured human endometrial endothelial cellsIL-8 immunoreactivityEffects of estradiolEutopic endometrial tissuesPathogenesis of endometriosisInterleukin-8 expressionMenstrual cycle phaseEndothelium-specific markersEndometriosis implantsInflammatory basisCytokine levelsEndometriotic implantsInflammatory mediatorsChemokine expressionEndometrial tissueInflammatory aspectsIL-8EndometriosisLuteal phase defect: myth or reality
Bukulmez O, Arici A. Luteal phase defect: myth or reality. Obstetrics And Gynecology Clinics Of North America 2004, 31: 727-744. PMID: 15550332, DOI: 10.1016/j.ogc.2004.08.007.Peer-Reviewed Original ResearchEndocrine‐Immune Interactions in Human Endometrium
KAYISLI UA, GUZELOGLU‐KAYISLI O, ARICI A. Endocrine‐Immune Interactions in Human Endometrium. Annals Of The New York Academy Of Sciences 2004, 1034: 50-63. PMID: 15731299, DOI: 10.1196/annals.1335.005.Peer-Reviewed Original ResearchConceptsProtein kinase BEndocrine-immune interactionsHuman endometriumBalanced regulationKinase BCell survivalImmune systemMolecular pathwaysApoptotic moleculesSurvival factorProgression of pregnancyWidespread associationReproductive systemTissue repairIndirect roleMenstrual bleedingApoptosisEndometrial cellsEndometrial differentiationNonresident cellsChemotactic cytokinesLeukocyte recruitmentSex steroidsBlastocyst implantationRegulationPhyto-oestrogens and the endometrium
Arici A, Bukulmez O. Phyto-oestrogens and the endometrium. The Lancet 2004, 364: 2081-2082. PMID: 15589297, DOI: 10.1016/s0140-6736(04)17565-x.Peer-Reviewed Original ResearchRegulation of Fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitro
Berkkanoglu M, Guzeloglu-Kayisli O, Kayisli U, Selam B, Arici A. Regulation of Fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitro. Molecular Human Reproduction 2004, 10: 393-398. PMID: 15073283, DOI: 10.1093/molehr/gah060.Peer-Reviewed Original ResearchConceptsStromal cell survivalCell survivalStromal cellsVascular endothelial growth factorEndometrial stromal cellsPotent mitogenic cytokineFasL expressionGrowth factorRegulation of FasLApoptotic signalingTranslation levelsFas ligand expressionWestern blot analysisEndothelial growth factorFas receptorFasL levelsBlot analysisFas ligandExpression of FasLConcentration-dependent mannerMitogenic cytokinesEffects of VEGFRegulationExpressionParacrine manner
2001
Regulation of Fas Ligand Expression by Estradiol and Progesterone in Human Endometrium1
Selam B, Kayisli U, Mulayim N, Arici A. Regulation of Fas Ligand Expression by Estradiol and Progesterone in Human Endometrium1. Biology Of Reproduction 2001, 65: 979-985. PMID: 11566716, DOI: 10.1095/biolreprod65.4.979.Peer-Reviewed Original ResearchConceptsFasL expressionSteroid hormonesEndometrial cellsHuman endometriumMenstrual cycle-dependent expressionGlandular cellsOvarian steroid hormonesSex steroid hormonesEndometrial glandular cellsLate proliferative phaseStrong FasL expressionFas ligand expressionFasL mRNA expressionReverse transcription-polymerase chain reaction analysisTranscription-polymerase chain reaction analysisFasL protein expressionMaternal immunotoleranceWestern blot analysisInteraction of FasLFasL immunoreactivityImplantation windowMenstrual cycleHuman Endometrium1Secretory phaseChain reaction analysisExpression of aminopeptidase N in human endometrium and regulation of its activity by estrogen
Seli E, Senturk L, Bahtiyar O, Kayisli U, Arici A. Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen. Fertility And Sterility 2001, 75: 1172-1176. PMID: 11384645, DOI: 10.1016/s0015-0282(01)01779-4.Peer-Reviewed Original ResearchConceptsExpression of APNEarly proliferative phaseMenstrual cycleInterleukin-8Human endometriumProliferative phaseCultured endometrial stromal cellsEndometrial stromal cell culturesEndometrial stromal cellsUniversity Medical CenterPolymorphonuclear leukocyte chemotaxisAPN activityAminopeptidase NConcentration-dependent mannerEndometrial pathologyEndometrial stromaProspective studyStromal cell culturesEndometrial sectionsAPN antibodyMedical CenterMAIN OUTCOMESex steroidsSecretory phaseEndometrium
2000
Implantation defect in endometriosis: endometrium or peritoneal fluid.
Selam B, Arici A. Implantation defect in endometriosis: endometrium or peritoneal fluid. Society Of Reproduction And Fertility 2000, 55: 121-8. PMID: 10889841.Peer-Reviewed Original ResearchConceptsEndometrial receptivityPeritoneal environmentRole of alterationsCytokine concentrationsPeritoneal fluidCell adhesion moleculeEndometriosisClinical observationsHormone analogueDirect actionAdhesion moleculesIron metabolismBiochemical factorsImplantation defectsImplantationWomenRecent studiesFluid microenvironmentPossible mechanismReceptivityEndometriumGonadotrophinDerangement
1999
Interleukin-8 expression in endometrial stromal cells is regulated by integrin-dependent cell adhesion
Garcia-Velasco J, Arici A. Interleukin-8 expression in endometrial stromal cells is regulated by integrin-dependent cell adhesion. Molecular Human Reproduction 1999, 5: 1135-1140. PMID: 10587368, DOI: 10.1093/molehr/5.12.1135.Peer-Reviewed Original ResearchIs the endometrium or oocyte/embryo affected in endometriosis?
Garcia-Velasco J, Arici A. Is the endometrium or oocyte/embryo affected in endometriosis? Human Reproduction 1999, 14: 77-89. PMID: 10690803, DOI: 10.1093/humrep/14.suppl_2.77.Peer-Reviewed Original ResearchConceptsOocyte/embryo qualityEmbryo qualityInadequate luteal functionOocyte donation programEffect of endometriosisEndometrium of womenOvarian steroid productionSpontaneous abortion rateSpectrum of conditionsOocytes/embryosImplantation rateEctopic endometriumEutopic endometriumClinical studiesLuteal functionUltrasound studyEndometriosisEndometriumOocyte qualityBiochemical markersSteroid productionDonation programAbortion rateWomenInfertilityRegulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Integrin-Dependent Cell Adhesion1
Garcia-Velasco J, Seli E, Arici A. Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Integrin-Dependent Cell Adhesion1. Biology Of Reproduction 1999, 61: 548-552. PMID: 10411539, DOI: 10.1095/biolreprod61.2.548.Peer-Reviewed Original ResearchConceptsCell adhesionExtracellular matrix connectionsActin cytoskeletonMCP-1 regulationGene expressionIntegrin activationECM substratesProtein secretionStromal cell adhesionCytochalasin DCell typesMCP-1 gene expressionNovel mechanismHuman endometrial stromal cellsMonocyte chemotactic protein-1 expressionProtein levelsIntegrinsProtein-1 expressionAdhesion matrixRegulationExpressionStromal cellsESC adhesionEndometrial stromal cellsCollagen IVInterleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin
Garcia-Velasco J, Arici A. Interleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin. Fertility And Sterility 1999, 72: 336-340. PMID: 10439007, DOI: 10.1016/s0015-0282(99)00223-x.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsInterleukin-8IL-8 monoclonal antibodyStromal cellsMonoclonal antibodiesBenign gynecologic surgeryPathogenesis of endometriosisConcentration-dependent increaseConcentration-dependent mannerEndometrial implantsEndometrial diseaseGynecologic surgeryMAIN OUTCOMEAntibodiesStromal cell adhesionAdhesion assaysAcademic research laboratoriesCellsCell adhesionEndometriosisSurgeryPathogenesisDiseaseWomenProgesterone Metabolism in Human Endometrial Stromal and Gland Cells in Culture
Arici A, Marshburn P, MacDonald P, Dombrowski R. Progesterone Metabolism in Human Endometrial Stromal and Gland Cells in Culture. Steroids 1999, 64: 530-534. PMID: 10493598, DOI: 10.1016/s0039-128x(99)00029-x.Peer-Reviewed Original ResearchConceptsMetabolism of progesteroneProgesterone metabolismHuman endometriumCultured endometrial cellsNormal human endometriumEndometrial StromalNormal endometriumProgesterone treatmentEndometrial cellsGland cellsEndometriumProgesteroneAbundant metabolitesMetabolismCell typesCellular fractionsCellsThin-layer chromatographySteroidsStromalRegulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Estrogen and Progesterone1
Arici A, Senturk L, Seli E, Bahtiyar M, Kim G. Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Estrogen and Progesterone1. Biology Of Reproduction 1999, 61: 85-90. PMID: 10377035, DOI: 10.1095/biolreprod61.1.85.Peer-Reviewed Original ResearchConceptsMCP-1 expressionEndometrial stromal cellsHuman endometrial stromal cellsMCP-1 levelsStromal cellsMacrophage migrationEstrogen levelsMCP-1 protein productionMonocyte chemotactic protein-1 expressionMCP-1 mRNA levelsChemotactic protein-1 expressionChemotactic protein-1Combination of E2Steroid hormone levelsProtein-1 expressionConcentration-dependent mannerEndometrial macrophagesMCP-1E2 treatmentHormone levelsSex steroidsEstradiol-17betaProgesteroneMRNA levelsProtein 1Macrophage derived growth factors m odulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis
Garcia-Velasco J, Arici A, Zreik T, Naftolin F, Mor G. Macrophage derived growth factors m odulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis. Molecular Human Reproduction 1999, 5: 642-650. PMID: 10381819, DOI: 10.1093/molehr/5.7.642.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCells, CulturedChoriocarcinomaCulture Media, ConditionedEndometriumFas Ligand ProteinFemaleFibroblast Growth Factor 2Gene Expression RegulationHumansLeukemia, MyeloidLigandsMacrophagesMembrane GlycoproteinsPlatelet-Derived Growth FactorPregnancyStromal CellsTransforming Growth Factor betaTumor Cells, CulturedUterine NeoplasmsConceptsBasic fibroblast growth factorEndometrial stromal cellsGrowth factorFasL expressionStromal cellsImmune cellsEndometrial cellsCultured endometrial stromal cellsEndometrial stromal cell culturesRegurgitated endometrial cellsImmune privilege statusPro-inflammatory naturePlatelet-derived growth factorMacrophage-conditioned mediumDose-dependent mannerFas ligand expressionFas ligand interactionsFibroblast growth factorStromal cell culturesPeritoneal fluidImmune surveillanceMacrophage productsLigand expressionCertain cell populationsCell populationsHOX gene expression is altered in the endometrium of women with endometriosis
Taylor H, Bagot C, Kardana A, Olive D, Arici A. HOX gene expression is altered in the endometrium of women with endometriosis. Human Reproduction 1999, 14: 1328-1331. PMID: 10325287, DOI: 10.1093/humrep/14.5.1328.Peer-Reviewed Original ResearchSex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium1
Taylor H, Igarashi P, Olive D, Arici A. Sex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium1. The Journal Of Clinical Endocrinology & Metabolism 1999, 84: 1129-1135. PMID: 10084606, DOI: 10.1210/jcem.84.3.5573.Peer-Reviewed Original ResearchConceptsHuman endometriumEndometrial developmentSex steroidsHuman endometrial developmentPeri-implantation endometriumMaintenance of pregnancyDose-responsive increaseAdult human endometriumTime of implantationMessenger RNA levelsProgesterone concentrationsEndometriumHOXA11 expressionPhysiologic rangeRNA levelsSteroidsPotential rolePregnancyImplantationEstrogenHOXA11ExpressionGene expressionSequential developmentNorthern analysis
1998
Interleukin-8 in the Human Endometrium1
Arici A, Seli E, Senturk L, Gutierrez L, Oral E, Taylor H. Interleukin-8 in the Human Endometrium1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 1783-1787. PMID: 9589693, DOI: 10.1210/jcem.83.5.4754.Peer-Reviewed Original ResearchConceptsIL-8 messenger ribonucleic acidInterleukin-8Menstrual cycleMessenger ribonucleic acidHuman endometriumMenstrual historyT cell chemotactic activityIL-8 mRNA levelsWoman's menstrual historyImmunoreactive IL-8IL-8 antibodyIL-8 expressionIL-8 proteinEndometrial biopsyEndometrial diseaseEndometrial tissueSex hormonesHuman uterusSurface epitheliumChemotactic activityEndometriumFrozen sectionsStromal cellsLate secretoryGlandular cellsInterleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1
Arici A, Seli E, Zeyneloglu H, Senturk L, Oral E, Olive D. Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 1201-1205. PMID: 9543141, DOI: 10.1210/jcem.83.4.4743.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsIL-8 productionInterleukin-8Sex steroid hormonesAutocrine growth factorGrowth factorEndometrial cellsCell proliferationSteroid hormonesStromal cellsEndometrial stromal cell proliferationNeutrophil chemoattractant/Potential autocrine growth factorProliferation of endometriumOligonucleotide treatmentPathogenesis of endometriosisProliferation inhibitory effectPotent angiogenic agentStromal cell proliferationConcentration-dependent inhibitionNumber of cytokinesConcentration-dependent increaseAntisense oligonucleotide treatmentEndometrial functionSpecific growth factors