2008
Regulation and activation of ezrin protein in endometriosis
Ornek T, Fadiel A, Tan O, Naftolin F, Arici A. Regulation and activation of ezrin protein in endometriosis. Human Reproduction 2008, 23: 2104-2112. PMID: 18552365, DOI: 10.1093/humrep/den215.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsEctopic endometrial tissuePathogenesis of endometriosisWestern blot analysisEndometrial tissueNormal endometriumEctopic endometrial stromal cellsNormal endometrial stromal cellsEctopic endometrial tissue samplesEndometrial tissue samplesEzrin proteinMembrane invasionBlot analysisExpression of ezrinEndometriosisStromal cellsEutopicPotential markerTissue samplesWomenInvasive characteristicsCell invasionEctopic sitesEndometriumInvasive potential
2005
Immunology of endometriosis.
Ulukus M, Arici A. Immunology of endometriosis. Minerva Obstetrics And Gynecology 2005, 57: 237-48. PMID: 16166933.Peer-Reviewed Original ResearchConceptsPathogenesis of endometriosisEctopic endometrial cellsEndometrial cellsAutoimmune diseasesImmune cellsNatural killer cell cytotoxicityPresence of autoantibodiesKiller cell cytotoxicityReproductive-age womenRetrograde menstruation theoryRetrograde menstruationCellular immunityHumoral immunityUterine cavityEctopic endometriumEndometriotic diseaseAge womenT cellsPeritoneal cavityEnigmatic disorderEndometriosisCell cytotoxicityImpaired capacityPathogenesisStromal cells
2004
Regulation of Interleukin-8 Expression in Human Endometrial Endothelial Cells: A Potential Mechanism for the Pathogenesis of Endometriosis
Luk J, Seval Y, Kayisli UA, Ulukus M, Ulukus CE, Arici A. Regulation of Interleukin-8 Expression in Human Endometrial Endothelial Cells: A Potential Mechanism for the Pathogenesis of Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 1805-1811. PMID: 15613411, DOI: 10.1210/jc.2004-1813.Peer-Reviewed Original ResearchConceptsHuman endometrial endothelial cellsIL-8 mRNAEndometrial endothelial cellsIL-8 expressionSex steroidsEndothelial cellsEutopic endometriumCultured human endometrial endothelial cellsIL-8 immunoreactivityEffects of estradiolEutopic endometrial tissuesPathogenesis of endometriosisInterleukin-8 expressionMenstrual cycle phaseEndothelium-specific markersEndometriosis implantsInflammatory basisCytokine levelsEndometriotic implantsInflammatory mediatorsChemokine expressionEndometrial tissueInflammatory aspectsIL-8Endometriosis
2003
Apoptosis and the Pathogenesis of Endometriosis
Garcia-Velasco J, Arici A. Apoptosis and the Pathogenesis of Endometriosis. Seminars In Reproductive Medicine 2003, 21: 165-172. PMID: 12917786, DOI: 10.1055/s-2003-41323.Peer-Reviewed Original ResearchConceptsPathogenesis of endometriosisEndometrial cellsSex steroid modulationDisease-free womenEutopic endometrial cellsBcl-2/BaxEndometriotic implantsSteroid modulationInflammatory environmentInflammatory reactionAbnormal survivalEndometriosisApoptosis-related genesFas ligandPhysiologic processesEarly eventsPathogenesisApoptosisEndometriosis
Arici A. Endometriosis. Seminars In Reproductive Medicine 2003, 21: 109-110. DOI: 10.1055/s-2003-41316.Peer-Reviewed Original ResearchPathogenesis of endometriosisDiagnosis of endometriosisAspects of endometriosisReproductive-aged womenTreatment of endometriosisCause of disabilityPathophysiology of endometriosisLevels of estrogenStudy of endometriosisCommon gynecologic disorderEstrogen-dependent diseaseNew therapeutic approachesPublic health concernPelvic painMedical therapySurgical managementPostsurgical managementCombination therapyGynecologic disordersOvarian functionClinical managementCell adhesion moleculeAged womenEnigmatic diseaseTherapeutic approaches
1999
The relevance of the peritoneal fluid in endometriosis-associated infertility
Mulayim N, Arici A. The relevance of the peritoneal fluid in endometriosis-associated infertility. Human Reproduction 1999, 14: 67-76. PMID: 10690802, DOI: 10.1093/humrep/14.suppl_2.67.Peer-Reviewed Original ResearchConceptsPeritoneal fluidEndometriosis-associated infertilityPathogenesis of endometriosisOccurrence of endometriosisImmunological factorsEndometriotic lesionsFertile womenGynaecological disordersEndometriosisEarly reproductive eventsHeterogenous symptomsImmunological differencesSteps of reproductionReproductive failureDiseaseRecent studiesClear conclusionsReproductive eventsInfertilityPathogenesisLesionsSymptomsWomenInterleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin
Garcia-Velasco J, Arici A. Interleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin. Fertility And Sterility 1999, 72: 336-340. PMID: 10439007, DOI: 10.1016/s0015-0282(99)00223-x.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsInterleukin-8IL-8 monoclonal antibodyStromal cellsMonoclonal antibodiesBenign gynecologic surgeryPathogenesis of endometriosisConcentration-dependent increaseConcentration-dependent mannerEndometrial implantsEndometrial diseaseGynecologic surgeryMAIN OUTCOMEAntibodiesStromal cell adhesionAdhesion assaysAcademic research laboratoriesCellsCell adhesionEndometriosisSurgeryPathogenesisDiseaseWomen
1998
Recent advances in endometriosis
Arici A, Pehlivan T. Recent advances in endometriosis. Current Opinion In Endocrinology Diabetes And Obesity 1998, 5: 330-340. DOI: 10.1097/00060793-199811000-00015.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPeritoneal fluidMaximal pain reliefEndometriosis-associated infertilityEffect of endometriosisChemoattractant protein-1Pathogenesis of endometriosisPain reliefPelvic painIL-10Pathophysiologic mechanismsTreatment optionsEctopic endometriumIL-13Endometrial cellsReproductive outcomesAromatase expressionMild lesionsSide effectsFertility outcomesMatrix metalloproteinasesEndometriosisPeritoneal macrophagesApoptosis markersIntegrin expressionProtein 1Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1
Arici A, Seli E, Zeyneloglu H, Senturk L, Oral E, Olive D. Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 1201-1205. PMID: 9543141, DOI: 10.1210/jcem.83.4.4743.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsIL-8 productionInterleukin-8Sex steroid hormonesAutocrine growth factorGrowth factorEndometrial cellsCell proliferationSteroid hormonesStromal cellsEndometrial stromal cell proliferationNeutrophil chemoattractant/Potential autocrine growth factorProliferation of endometriumOligonucleotide treatmentPathogenesis of endometriosisProliferation inhibitory effectPotent angiogenic agentStromal cell proliferationConcentration-dependent inhibitionNumber of cytokinesConcentration-dependent increaseAntisense oligonucleotide treatmentEndometrial functionSpecific growth factors
1997
PATHOGENESIS OF ENDOMETRIOSIS
Oral E, Arici A. PATHOGENESIS OF ENDOMETRIOSIS. Obstetrics And Gynecology Clinics Of North America 1997, 24: 219-233. PMID: 9163764, DOI: 10.1016/s0889-8545(05)70301-6.Peer-Reviewed Original ResearchMonocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells
Arici A, Oral E, Attar E, Tazuke S, Olive D. Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells. Fertility And Sterility 1997, 67: 1065-1072. PMID: 9176445, DOI: 10.1016/s0015-0282(97)81440-9.Peer-Reviewed Original ResearchConceptsMonocyte chemotactic protein-1Chemotactic protein-1 levelsChemotactic protein-1Protein-1 levelsChemotactic protein-1 concentrationsProtein-1 concentrationsPeritoneal fluidMesothelial cellsPg/Severe endometriosisProtein 1Control womenSecretory phaseProliferative phaseSevere endometriosis groupPathogenesis of endometriosisPeritoneal mesothelial cellsInterleukin-1 alphaUniversity Medical CenterMessenger RNA expressionUntreated endometriosisGnRH agonistEndometriosis groupModerate endometriosisProspective study