2008
Regulation and activation of ezrin protein in endometriosis
Ornek T, Fadiel A, Tan O, Naftolin F, Arici A. Regulation and activation of ezrin protein in endometriosis. Human Reproduction 2008, 23: 2104-2112. PMID: 18552365, DOI: 10.1093/humrep/den215.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsEctopic endometrial tissuePathogenesis of endometriosisWestern blot analysisEndometrial tissueNormal endometriumEctopic endometrial stromal cellsNormal endometrial stromal cellsEctopic endometrial tissue samplesEndometrial tissue samplesEzrin proteinMembrane invasionBlot analysisExpression of ezrinEndometriosisStromal cellsEutopicPotential markerTissue samplesWomenInvasive characteristicsCell invasionEctopic sitesEndometriumInvasive potential
2004
Regulation of Fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitro
Berkkanoglu M, Guzeloglu-Kayisli O, Kayisli U, Selam B, Arici A. Regulation of Fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitro. Molecular Human Reproduction 2004, 10: 393-398. PMID: 15073283, DOI: 10.1093/molehr/gah060.Peer-Reviewed Original ResearchConceptsStromal cell survivalCell survivalStromal cellsVascular endothelial growth factorEndometrial stromal cellsPotent mitogenic cytokineFasL expressionGrowth factorRegulation of FasLApoptotic signalingTranslation levelsFas ligand expressionWestern blot analysisEndothelial growth factorFas receptorFasL levelsBlot analysisFas ligandExpression of FasLConcentration-dependent mannerMitogenic cytokinesEffects of VEGFRegulationExpressionParacrine manner
2002
Regulation of fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitro
Berkkanoglu M, Kayisli U, Guzeloglu-Kayisli O, Selam B, Arici A. Regulation of fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitro. Fertility And Sterility 2002, 78: s280. DOI: 10.1016/s0015-0282(02)03939-0.Peer-Reviewed Original Research
2001
Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen
Seli E, Senturk L, Bahtiyar O, Kayisli U, Arici A. Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen. Fertility And Sterility 2001, 75: 1172-1176. PMID: 11384645, DOI: 10.1016/s0015-0282(01)01779-4.Peer-Reviewed Original ResearchConceptsExpression of APNEarly proliferative phaseMenstrual cycleInterleukin-8Human endometriumProliferative phaseCultured endometrial stromal cellsEndometrial stromal cell culturesEndometrial stromal cellsUniversity Medical CenterPolymorphonuclear leukocyte chemotaxisAPN activityAminopeptidase NConcentration-dependent mannerEndometrial pathologyEndometrial stromaProspective studyStromal cell culturesEndometrial sectionsAPN antibodyMedical CenterMAIN OUTCOMESex steroidsSecretory phaseEndometrium
1999
Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Integrin-Dependent Cell Adhesion1
Garcia-Velasco J, Seli E, Arici A. Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Integrin-Dependent Cell Adhesion1. Biology Of Reproduction 1999, 61: 548-552. PMID: 10411539, DOI: 10.1095/biolreprod61.2.548.Peer-Reviewed Original ResearchConceptsCell adhesionExtracellular matrix connectionsActin cytoskeletonMCP-1 regulationGene expressionIntegrin activationECM substratesProtein secretionStromal cell adhesionCytochalasin DCell typesMCP-1 gene expressionNovel mechanismHuman endometrial stromal cellsMonocyte chemotactic protein-1 expressionProtein levelsIntegrinsProtein-1 expressionAdhesion matrixRegulationExpressionStromal cellsESC adhesionEndometrial stromal cellsCollagen IVInterleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin
Garcia-Velasco J, Arici A. Interleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin. Fertility And Sterility 1999, 72: 336-340. PMID: 10439007, DOI: 10.1016/s0015-0282(99)00223-x.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsInterleukin-8IL-8 monoclonal antibodyStromal cellsMonoclonal antibodiesBenign gynecologic surgeryPathogenesis of endometriosisConcentration-dependent increaseConcentration-dependent mannerEndometrial implantsEndometrial diseaseGynecologic surgeryMAIN OUTCOMEAntibodiesStromal cell adhesionAdhesion assaysAcademic research laboratoriesCellsCell adhesionEndometriosisSurgeryPathogenesisDiseaseWomenRegulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Estrogen and Progesterone1
Arici A, Senturk L, Seli E, Bahtiyar M, Kim G. Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Estrogen and Progesterone1. Biology Of Reproduction 1999, 61: 85-90. PMID: 10377035, DOI: 10.1095/biolreprod61.1.85.Peer-Reviewed Original ResearchConceptsMCP-1 expressionEndometrial stromal cellsHuman endometrial stromal cellsMCP-1 levelsStromal cellsMacrophage migrationEstrogen levelsMCP-1 protein productionMonocyte chemotactic protein-1 expressionMCP-1 mRNA levelsChemotactic protein-1 expressionChemotactic protein-1Combination of E2Steroid hormone levelsProtein-1 expressionConcentration-dependent mannerEndometrial macrophagesMCP-1E2 treatmentHormone levelsSex steroidsEstradiol-17betaProgesteroneMRNA levelsProtein 1Macrophage derived growth factors m odulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis
Garcia-Velasco J, Arici A, Zreik T, Naftolin F, Mor G. Macrophage derived growth factors m odulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis. Molecular Human Reproduction 1999, 5: 642-650. PMID: 10381819, DOI: 10.1093/molehr/5.7.642.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCells, CulturedChoriocarcinomaCulture Media, ConditionedEndometriumFas Ligand ProteinFemaleFibroblast Growth Factor 2Gene Expression RegulationHumansLeukemia, MyeloidLigandsMacrophagesMembrane GlycoproteinsPlatelet-Derived Growth FactorPregnancyStromal CellsTransforming Growth Factor betaTumor Cells, CulturedUterine NeoplasmsConceptsBasic fibroblast growth factorEndometrial stromal cellsGrowth factorFasL expressionStromal cellsImmune cellsEndometrial cellsCultured endometrial stromal cellsEndometrial stromal cell culturesRegurgitated endometrial cellsImmune privilege statusPro-inflammatory naturePlatelet-derived growth factorMacrophage-conditioned mediumDose-dependent mannerFas ligand expressionFas ligand interactionsFibroblast growth factorStromal cell culturesPeritoneal fluidImmune surveillanceMacrophage productsLigand expressionCertain cell populationsCell populations
1998
Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1
Arici A, Seli E, Zeyneloglu H, Senturk L, Oral E, Olive D. Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 1201-1205. PMID: 9543141, DOI: 10.1210/jcem.83.4.4743.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsIL-8 productionInterleukin-8Sex steroid hormonesAutocrine growth factorGrowth factorEndometrial cellsCell proliferationSteroid hormonesStromal cellsEndometrial stromal cell proliferationNeutrophil chemoattractant/Potential autocrine growth factorProliferation of endometriumOligonucleotide treatmentPathogenesis of endometriosisProliferation inhibitory effectPotent angiogenic agentStromal cell proliferationConcentration-dependent inhibitionNumber of cytokinesConcentration-dependent increaseAntisense oligonucleotide treatmentEndometrial functionSpecific growth factors
1996
Modulation of the levels of interleukin-8 messenger ribonucleic acid and interleukin-8 protein synthesis in human endometrial stromal cells by transforming growth factor-beta 1
Arici A. Modulation of the levels of interleukin-8 messenger ribonucleic acid and interleukin-8 protein synthesis in human endometrial stromal cells by transforming growth factor-beta 1. The Journal Of Clinical Endocrinology & Metabolism 1996, 81: 3004-3009. DOI: 10.1210/jc.81.8.3004.Peer-Reviewed Original ResearchModulation of the levels of interleukin-8 messenger ribonucleic acid and interleukin-8 protein synthesis in human endometrial stromal cells by transforming growth factor-beta 1
Arici A, MacDonald P, Casey M. Modulation of the levels of interleukin-8 messenger ribonucleic acid and interleukin-8 protein synthesis in human endometrial stromal cells by transforming growth factor-beta 1. The Journal Of Clinical Endocrinology & Metabolism 1996, 81: 3004-3009. PMID: 8768866, DOI: 10.1210/jcem.81.8.8768866.Peer-Reviewed Original ResearchConceptsIL-8 messenger ribonucleic acidEndometrial stromal cellsHuman endometrial stromal cellsMessenger ribonucleic acidIL-8TGF beta 1Stromal cellsChemotactic factorsInterleukin-8 messenger ribonucleic acidT-cell chemotactic factorBone marrow-derived cellsBeta 1Ovarian steroid secretionTGF beta 1 treatmentImmunoreactive IL-8Marrow-derived cellsEndometrium/deciduaInterleukin-8 gene expressionIL-8 geneParacrine-acting factorsOvulatory womenEndometrial decidualizationEndometrial stromaSteroid secretionLeukocyte populationsProgestin regulation of interleukin-8 mRNA levels and protein synthesis in human endometrial stromal cells
Arici A, MacDonald P, Casey M. Progestin regulation of interleukin-8 mRNA levels and protein synthesis in human endometrial stromal cells. The Journal Of Steroid Biochemistry And Molecular Biology 1996, 58: 71-76. PMID: 8809187, DOI: 10.1016/0960-0760(96)00016-7.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCells, CulturedDactinomycinEndometriumFemaleGene Expression RegulationHumansInterleukin-1Interleukin-8Medroxyprogesterone AcetateMolecular Sequence DataProgesteroneProgesterone CongenersProgestinsProtein Synthesis InhibitorsRecombinant ProteinsRNA, MessengerStromal CellsTranscription, GeneticConceptsIL-8 mRNAHuman endometrial stromal cellsEndometrial stromal cellsInterleukin-8IL-1Stromal cellsInterleukin-8 mRNA levelsNormal human pregnancyIL-8 gene transcriptionFormation of cytokinesMigration of leukocytesConcentration-dependent mannerEndometrial repairHuman pregnancyLeukocytic infiltrationDecidual tissuesHuman endometriumT cellsProgestin regulationSynthetic progestinsUterine endometriumUterine involutionHormonal eventsOvarian cycleEndometriumModulation of the Levels of Transforming Growth Factor β Messenger Ribonucleic Acids in Human Endometrial Stromal Cells1
Arici A, MacDonald P, Casey M. Modulation of the Levels of Transforming Growth Factor β Messenger Ribonucleic Acids in Human Endometrial Stromal Cells1. Biology Of Reproduction 1996, 54: 463-469. PMID: 8788200, DOI: 10.1095/biolreprod54.2.463.Peer-Reviewed Original ResearchConceptsTGF beta 3 mRNAEndometrial stromal cellsTGF beta 1 mRNATGF beta 1Beta 3 mRNAHuman endometrial stromal cellsBeta 1 mRNAPlatelet-derived growth factorStromal cellsBeta 1Proliferative phase endometrial tissueTGF beta 2 mRNATGF-beta mRNA levelsGrowth factorTGF beta 1 treatmentProliferative phase endometriumEstradiol-17 betaLate secretory phaseSecretory phase tissuesBeta 2 mRNABeta mRNA levelsGrowth factor betaDose-dependent mannerTotal RNATime-dependent fashion
1995
Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium
Arici A, Engin O, Attar E, Olive D. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium. The Journal Of Clinical Endocrinology & Metabolism 1995, 80: 1908-1915. PMID: 7775640, DOI: 10.1210/jcem.80.6.7775640.Peer-Reviewed Original ResearchMeSH KeywordsAdultBloodCells, CulturedCulture MediaDeciduaEndometriumEpidermal Growth FactorFemaleGene Expression RegulationGrowth InhibitorsHumansInterferon-gammaInterleukin-1Interleukin-6Leukemia Inhibitory FactorLymphokinesMiddle AgedPlatelet-Derived Growth FactorPregnancyProtein BiosynthesisRNA, MessengerTransforming Growth Factor betaTumor Necrosis Factor-alphaConceptsExpression of LIFLeukemia inhibitory factorLIF expressionLIF mRNAEndometrial cellsGrowth factorHuman endometriumLeukemia inhibitory factor gene expressionMenstrual cycle-dependent mannerRole of LIFSteroid hormonesHuman implantationLIF mRNA expressionEndometrial stromal cellsEndometrium/deciduaHuman endometrial cellsPlatelet-derived growth factorEndometrial gland cellsMessenger ribonucleic acid levelsRibonucleic acid levelsMidluteal endometriumFactor gene expressionTime-dependent mannerFirst trimesterTumor necrosisRegulation of monocyte chemotactic protein-1 gene expression in human endometrial cells in cultures
Arici A, MacDonald P, Casey M. Regulation of monocyte chemotactic protein-1 gene expression in human endometrial cells in cultures. Molecular And Cellular Endocrinology 1995, 107: 189-197. PMID: 7768330, DOI: 10.1016/0303-7207(94)03442-v.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCells, CulturedChemokine CCL2Chemotactic FactorsCulture MediaDeciduaDNA PrimersEndometriumEpithelial CellsEpitheliumFemaleGene Expression RegulationHalf-LifeHumansInterleukin-1Menstrual CycleMolecular Sequence DataPlatelet-Derived Growth FactorPregnancyRNA, MessengerTranscription, GeneticTumor Necrosis Factor-alphaConceptsMCP-1 mRNAMonocyte chemotactic protein-1Endometrial stromal cellsEndometrium/deciduaStromal cellsBone marrow-derived leukocytesHuman endometrial stromal cellsEpithelial cellsChemotactic protein-1 gene expressionDuration of pregnancyChemotactic protein-1Human endometrial tissueMonocyte chemotactic protein-1 gene expressionHuman endometrial cellsHuman endometrium/deciduaDay of cycleProtein-1 gene expressionTotal RNAMacrophage chemotacticTypes of leukocytesEndometrial tissueHormonal milieuDecidua parietalisEndometrial cellsHuman endometrium
1994
Expression of transforming growth factor-β1 messenger ribonucleic acid and the modulation of deoxyribonucleic acid synthesis by transforming growth factor-β1 in human endometrial cells
Marshburn P, Arici A, Casey M. Expression of transforming growth factor-β1 messenger ribonucleic acid and the modulation of deoxyribonucleic acid synthesis by transforming growth factor-β1 in human endometrial cells. American Journal Of Obstetrics And Gynecology 1994, 170: 1152-1158. PMID: 8166201, DOI: 10.1016/s0002-9378(94)70112-1.Peer-Reviewed Original ResearchConceptsEstradiol-17 betaEndometrial stromal cellsEndometrial glandsMessenger ribonucleic acidStromal cellsHuman endometriumDeoxyribonucleic acid synthesisGlandular epitheliumEpithelial cellsEndometrial glandular epitheliumEndometrial cell proliferationStromal cell originHuman endometrial cellsGrowth factor-β1Acid synthesisRibonucleic acidSecretory endometriumEndometrial cellsTrichloroacetic acid-precipitable materialEndometrial epitheliumSecretory phaseFactor-β1Cell originAcid-precipitable materialEndometrium
1993
Regulation of interleukin-8 gene expression in human endometrial cells in culture
Arici A, Head J, MacDonald P, Casey M. Regulation of interleukin-8 gene expression in human endometrial cells in culture. Molecular And Cellular Endocrinology 1993, 94: 195-204. PMID: 8224523, DOI: 10.1016/0303-7207(93)90168-j.Peer-Reviewed Original ResearchConceptsIL-8 mRNAEndometrial stromal cellsIL-1 alphaInterleukin-8 gene expressionEndometrial epithelial cellsStromal cellsEpithelial cellsIL-8 mRNA levelsImmunoreactive IL-8IL-8 gene expressionIL-8 gene transcriptionHuman endometrial cellsRecruitment of leukocytesIL-1 treatmentConcentration-dependent mannerIL-8Endometrial cellsTumor necrosisHuman endometriumGene expressionIL-1Glandular epitheliumSerum-free mediumSerum treatmentPresence of serum