Featured Publications
A Guide for the Implementation of Group-Based Metacognitive Reflection and Insight Therapy (MERITg)
Martin A, Bullock J, Fiszdon J, Stacy M, Martino S, James A, Lysaker P. A Guide for the Implementation of Group-Based Metacognitive Reflection and Insight Therapy (MERITg). Journal Of Contemporary Psychotherapy 2022, 53: 91-98. DOI: 10.1007/s10879-022-09560-9.Peer-Reviewed Original ResearchTranslating an Integrative Metacognitive Model of Psychotherapy for Serious Mental Illness Into a Group Format: A Pilot Investigation on Feasibility
Martin A, Bullock J, Fiszdon J, Stacy M, Martino S, James AV, Wiesepape C, Lysaker PH. Translating an Integrative Metacognitive Model of Psychotherapy for Serious Mental Illness Into a Group Format: A Pilot Investigation on Feasibility. Psychological Services 2024, 21: 130-138. PMID: 36066852, PMCID: PMC10484016, DOI: 10.1037/ser0000706.Peer-Reviewed Original ResearchSerious mental illnessMental illnessOutpatient psychiatric settingsRoutine clinical careGroup-based interventionBody of evidenceClinical carePsychiatric settingsIllnessPilot investigationInsight therapyGroup formatProgram evaluation measuresClinical demandGroup psychotherapyInterventionGroupParticipantsInpatientsPsychotherapyTherapyAuditory feature perception and auditory hallucinatory experiences in schizophrenia spectrum disorder
Schnakenberg Martin AM, Bartolomeo L, Howell J, Hetrick WP, Bolbecker AR, Breier A, Kidd G, O’Donnell B. Auditory feature perception and auditory hallucinatory experiences in schizophrenia spectrum disorder. European Archives Of Psychiatry And Clinical Neuroscience 2017, 268: 653-661. PMID: 28936548, PMCID: PMC7126185, DOI: 10.1007/s00406-017-0839-1.Peer-Reviewed Original ResearchConceptsAuditory verbal hallucinationsSchizophrenia spectrum disordersAuditory perceptionSZ individualsFeature perceptionVerbal hallucinationsSpectrum disorderAuditory featuresImpaired auditory perceptionSchizophrenia Voices QuestionnaireBasic Auditory CapabilitiesTemporal order discriminationAuditory hallucinatory experiencesCognitive processingTone taskOrder discriminationHamilton ProgramHallucinatory experiencesGreater deficitsSZ groupAuditory hallucinationsAuditory capabilitiesPerceptionVoice QuestionnaireIntellectual impairmentDifferential Cognitive Performance in Females and Males with Regular Cannabis Use
Martin A, D’Souza D, Newman SD, Hetrick WP, O’Donnell B. Differential Cognitive Performance in Females and Males with Regular Cannabis Use. Journal Of The International Neuropsychological Society 2021, 27: 570-580. PMID: 34261548, PMCID: PMC8830784, DOI: 10.1017/s1355617721000606.Peer-Reviewed Original ResearchConceptsRegular cannabis useCannabis useCognitive measuresPsychomotor speedBiological sexHopkins Verbal Learning TestDifferential cognitive performanceNon-using peersVerbal Learning TestMeasures of intelligenceWechsler Abbreviated ScaleDigit symbol testGreatest group differencesVerbal learningDigit spanLearning TestCognitive performanceAbbreviated ScaleNeurocognitive deficitsCognitive deficitsSymbol testCannabis exposurePsychomotor performanceGroup differencesCognitionCompared to high and low cannabis use, moderate use is associated with fewer cognitive deficits in psychosis
Martin A, Bonfils KA, Davis BJ, Smith EA, Schuder K, Lysaker PH. Compared to high and low cannabis use, moderate use is associated with fewer cognitive deficits in psychosis. Schizophrenia Research Cognition 2016, 6: 15-21. PMID: 28740820, PMCID: PMC5514308, DOI: 10.1016/j.scog.2016.09.001.Peer-Reviewed Original ResearchLifetime cannabisCannabis useLess impairmentGroup of patientsDose related responsePoor levelCannabis/Assessment of neurocognitionLifetime cannabis usePoor cognitionSevere impairmentCognitive deficitsCognitive functionLower cannabisModerate cannabisCannabisSchizophreniaImpairmentHigher cannabisNeurocognition
2024
Recent Advances in Prevention and Recovery in People with Schizophrenia and Related Disorders
Schnakenberg Martin A, Bonfils K. Recent Advances in Prevention and Recovery in People with Schizophrenia and Related Disorders. Behavioral Sciences 2024, 14: 988. DOI: 10.3390/bs14110988.Peer-Reviewed Original ResearchGroup-Based Metacognitive Reflection and Insight Therapy (MERITg) and Its Relationship to Recovery-Oriented Beliefs in Serious Mental Illness
Musket C, Bullock J, Fiszdon J, Stacy M, Martino S, James A, Lysaker P, Martin A. Group-Based Metacognitive Reflection and Insight Therapy (MERITg) and Its Relationship to Recovery-Oriented Beliefs in Serious Mental Illness. Behavioral Sciences 2024, 14: 520. PMID: 39062343, PMCID: PMC11273885, DOI: 10.3390/bs14070520.Peer-Reviewed Original ResearchSerious mental illnessMental illnessMaryland Assessment of RecoveryRecovery-oriented interventionsInsight TherapyThirty-one participantsAssessment of recoveryGroup participantsShort formEvidence-basedInpatient groupTreatment settingsMetacognitive reflectionTreatment programsParticipantsIllnessTherapeutic interactionSMIThirty-oneBeliefsAdjunctive treatmentInterventionGroupMarylandTherapyPsychotherapy to Emphasize Self-Directed Recovery for Persons With Serious Mental Illness: Contributions From Metacognitive Reflection and Insight Therapy (MERIT)
Faith L, Wiesepape C, Bonfils K, Lysaker P, Martin A. Psychotherapy to Emphasize Self-Directed Recovery for Persons With Serious Mental Illness: Contributions From Metacognitive Reflection and Insight Therapy (MERIT). Psychological Services 2024 PMID: 38780561, DOI: 10.1037/ser0000865.Peer-Reviewed Original ResearchSelf-directed recoveryEvidence-based psychotherapiesMental illnessMetacognitive reflectionLevels of mental health careSerious mental illnessMental health careIndividual psychotherapyInsight TherapyMetacognitive capacityTreatment of peopleSymptom reductionPsychotherapyInterpersonal environmentLevel of trainingHealth careMetacognitive frameworkRecovery outcomesSMIPersonsSelf-determinationFunctional improvementSocial workersCareIllness
2023
Cannabis Causes Positive, Negative, and Cognitive Symptoms and Produces Impairments in Electrophysiological Indices of Information Processing
Martin A, Ranganathan M, D’Souza D. Cannabis Causes Positive, Negative, and Cognitive Symptoms and Produces Impairments in Electrophysiological Indices of Information Processing. 2023, 156-166. DOI: 10.1017/9781108943246.017.Peer-Reviewed Original ResearchMental illnessMental health teamsHealth policy implicationsHigh-potency cannabisStages of neurodevelopmentPotential adverse effectsHealth teamsImpact of exposureCognitive symptomsCannabis dependenceAdverse effectsCannabisSynthetic cannabinoidsIllnessPsychosisCannabinoidsElectrophysiological indicesNew research findingsAssociationComplex associationSymptomsPutative modelNeurodevelopmentSchizophreniaImpairmentPreliminary study of the interactive effects of THC and ethanol on self-reported ability and simulated driving, subjective effects, and cardiovascular responses
Schnakenberg Martin A, Flynn L, Sefik E, Luddy C, Cortes-Briones J, Skosnik P, Pittman B, Ranganathan M, D’Souza D. Preliminary study of the interactive effects of THC and ethanol on self-reported ability and simulated driving, subjective effects, and cardiovascular responses. Psychopharmacology 2023, 240: 1235-1246. PMID: 37045988, DOI: 10.1007/s00213-023-06356-0.Peer-Reviewed Original ResearchConceptsSubjective effectsOral tetrahydrocannabinolSelf-reported abilityEffects of cannabisInfluence of tetrahydrocannabinolCause of morbiditySimulated drivingFeeling statesBlood alcohol levelsMotor vehicle accidentsAlcohol-related motor vehicle accidentsCardiovascular responsesIntravenous ethanolHealthy humansHeart rateVehicle accidentsAlcohol levelsInteractive effectsTetrahydrocannabinolPhysiological effectsSignificant differencesDrivingAbilityPreliminary studyRationaleDrug
2022
The Relationship Between Cannabinoids and Neural Oscillations: How Cannabis Disrupts Sensation, Perception, and Cognition
Syed S, Martin A, Cortes-Briones J, Skosnik P. The Relationship Between Cannabinoids and Neural Oscillations: How Cannabis Disrupts Sensation, Perception, and Cognition. Clinical EEG And Neuroscience 2022, 54: 359-369. PMID: 36426543, DOI: 10.1177/15500594221138280.Peer-Reviewed Original ResearchConceptsNeural oscillationsNeural synchronyImportant clinical implicationsExcitatory balanceTheta frequency rangeClinical studiesClinical implicationsNeural circuitsCannabis useBrain functionOscillatory disruptionsNeural activityCannabinoidsSensationPotential relationshipCritical mechanismElectroencephalographyDisruptionSchizophreniaThe relationship between cannabis use and taurine: A MRS and metabolomics study
Newman S, Martin A, Raymond D, Cheng H, Wilson L, Barnes S, O’Donnell B. The relationship between cannabis use and taurine: A MRS and metabolomics study. PLOS ONE 2022, 17: e0269280. PMID: 35653401, PMCID: PMC9162360, DOI: 10.1371/journal.pone.0269280.Peer-Reviewed Original ResearchConceptsTaurine levelsCB useBody compositionLow-BMI individualsDorsal anterior cingulateMagnetic resonance spectroscopyNon-user groupNeuroprotective effectsBMI individualsNeurotoxic effectsMRS studiesUrine analysisAnterior cingulateCannabis useSimilar findingsUrine samplesTaurineEssential amino acidsMetabolomic analysisMetabolomics studiesGlutamateCurrent studyGroupBMILevelsDelta-9-Tetrahydrocannabinol, Cannabidiol, and Acute Psychotomimetic States: A Balancing Act of the Principal Phyto-Cannabinoids on Human Brain and Behavior
Ganesh S, Cortes-Briones J, Martin A, Skosnik PD, D'Souza DC, Ranganathan M. Delta-9-Tetrahydrocannabinol, Cannabidiol, and Acute Psychotomimetic States: A Balancing Act of the Principal Phyto-Cannabinoids on Human Brain and Behavior. Cannabis And Cannabinoid Research 2022, 8: 846-856. PMID: 35319274, PMCID: PMC10589482, DOI: 10.1089/can.2021.0166.Peer-Reviewed Original ResearchConceptsPsychotomimetic effectsHuman laboratory studiesDifferent dose ratiosDose-related interactionDelta-9-TetrahydrocannabinolLower CBDNeural noiseRatio-dependent mannerCannabis liberalizationHealthy volunteersElectrophysiological biomarkersMedical indicationsPsychotomimetic statesSpecific brainDose ratioPrior exposureObjective effectsHuman brainMaximal attenuationBrainTHCAntagonistic effectCannabis plantNeuroscience investigationsBehavioral responses
2021
Metacognition, Adaptation, and Mental Health
Schnakenberg Martin A, Lysaker P. Metacognition, Adaptation, and Mental Health. Biological Psychiatry 2021, 91: e31-e32. PMID: 34961623, DOI: 10.1016/j.biopsych.2021.09.028.Peer-Reviewed Original ResearchTreatment outcomes in individuals diagnosed with comorbid opioid use disorder and Posttraumatic stress disorder: A review
Meshberg-Cohen S, MacLean R, Martin A, Sofuoglu M, Petrakis IL. Treatment outcomes in individuals diagnosed with comorbid opioid use disorder and Posttraumatic stress disorder: A review. Addictive Behaviors 2021, 122: 107026. PMID: 34182307, DOI: 10.1016/j.addbeh.2021.107026.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderComorbid opioid use disorderStress disorderImpact of PTSDPresence of PTSDComorbid posttraumatic stress disorderUse disordersOpioid use disorderMultiple mental health problemsMental health problemsPTSD treatmentComparison participantsTreatment outcomesPTSD diagnosisPsychosocial problemsStandardized assessmentConcurrent diagnosisPsychiatric conditionsMedical record diagnosisDrug useIndividualsDisordersPublic health emergencyRecord diagnosisInclusion criteriaAltered cerebellar-cortical resting-state functional connectivity in cannabis users
Martin A, Kim DJ, Newman SD, Cheng H, Hetrick WP, Mackie K, O’Donnell B. Altered cerebellar-cortical resting-state functional connectivity in cannabis users. Journal Of Psychopharmacology 2021, 35: 823-832. PMID: 34034553, PMCID: PMC8813046, DOI: 10.1177/02698811211019291.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityNon-using peersCannabis usersCannabis useFunctional connectivityRegular cannabis usersPosterior cingulate cortexAnterior cerebellar regionsNon-motor phenomenaCingulate cortexCerebellar regionsBrain regionsAge of initiationCerebral regionsCerebellar lobulesCortexPeersLifetime useUnbiased atlas templateIndividual voxelsCerebral cortexReceptor densityCognitionCerebellumAtlas template
2020
Meaning, integration, and the self in serious mental illness: Implications of research in metacognition for psychiatric rehabilitation.
Lysaker PH, Kukla M, Leonhardt BL, Hamm JA, Schnakenberg Martin A, Zalzala AB, Gagen EC, Hasson-Ohayon I. Meaning, integration, and the self in serious mental illness: Implications of research in metacognition for psychiatric rehabilitation. Psychiatric Rehabilitation Journal 2020, 43: 275-283. PMID: 32790437, DOI: 10.1037/prj0000436.Peer-Reviewed Original ResearchIn an exploratory randomized, double-blind, placebo-controlled, cross-over study, psychoactive doses of intravenous delta-9-tetrahydrocannabinol fail to produce antinociceptive effects in healthy human volunteers
Schindler EAD, Schnakenberg Martin AM, Sewell RA, Ranganathan M, DeForest A, Pittman BP, Perrino A, D’Souza D. In an exploratory randomized, double-blind, placebo-controlled, cross-over study, psychoactive doses of intravenous delta-9-tetrahydrocannabinol fail to produce antinociceptive effects in healthy human volunteers. Psychopharmacology 2020, 237: 3097-3107. PMID: 32632491, DOI: 10.1007/s00213-020-05595-9.Peer-Reviewed Original ResearchConceptsCapsaicin-induced hyperalgesiaCross-over studyHealthy human subjectsIntravenous THCAcute painAntinociceptive effectDrug effectsDrug AdministrationHuman subjectsDose-related mannerPeak drug effectHealthy human volunteersSignificant antinociceptive propertiesRationaleAnimal studiesElectrical painPain conditionsPain managementChemical painPain ratingsAntinociceptive propertiesHealthy volunteersPsychoactive dosesAcute chemicalHuman studiesCognitive alterations
2019
An investigation of the relationship between glutamate and resting state connectivity in chronic cannabis users
Newman SD, Cheng H, Kim DJ, Schnakenberg-Martin A, Dydak U, Dharmadhikari S, Hetrick W, O’Donnell B. An investigation of the relationship between glutamate and resting state connectivity in chronic cannabis users. Brain Imaging And Behavior 2019, 14: 2062-2071. PMID: 31302844, PMCID: PMC6955389, DOI: 10.1007/s11682-019-00165-w.Peer-Reviewed Original ResearchConceptsNucleus accumbensGlu levelsState connectivityMultimodal MRI studyState functional connectivityRight nucleus accumbensCB useChronic cannabis usersNAc connectivityHealthy controlsGlutamatergic signalingMRI studiesAnimal studiesCurrent preliminary studyLarger sample sizeMagnetic resonance spectroscopyFunctional connectivityHeavy cannabisCannabis usersCannabisReward networkCB usersLinear regression modelsRSFCEffect sizeIndividuals with psychosis and a lifetime history of cannabis use show greater deficits in emotional experience compared to non-using peers
Martin A, Lysaker PH. Individuals with psychosis and a lifetime history of cannabis use show greater deficits in emotional experience compared to non-using peers. Journal Of Mental Health 2019, 29: 77-83. PMID: 30822177, DOI: 10.1080/09638237.2018.1487540.Peer-Reviewed Original ResearchConceptsEmotional Expressivity ScaleEmotional experienceSocial Functioning ScaleEmotional expressionAnticipatory pleasureLifetime cannabisSocial functioningGreater deficitsSocial functionCannabis useNon-using peersAnticipation of pleasureExperience of pleasurePoor social functionEmotional expressivityLifetime historyAnticipatory anhedoniaProsocial activitiesActive cannabisPleasure ScaleTemporal experienceHistory of cannabisFunctioning ScaleEarly psychosisPrevious research