2019
An investigation of the relationship between glutamate and resting state connectivity in chronic cannabis users
Newman SD, Cheng H, Kim DJ, Schnakenberg-Martin A, Dydak U, Dharmadhikari S, Hetrick W, O’Donnell B. An investigation of the relationship between glutamate and resting state connectivity in chronic cannabis users. Brain Imaging And Behavior 2019, 14: 2062-2071. PMID: 31302844, PMCID: PMC6955389, DOI: 10.1007/s11682-019-00165-w.Peer-Reviewed Original ResearchMeSH KeywordsCannabisFemaleGlutamic AcidGyrus CinguliHumansMagnetic Resonance SpectroscopyMaleMarijuana SmokingRestYoung AdultConceptsNucleus accumbensGlu levelsState connectivityMultimodal MRI studyState functional connectivityRight nucleus accumbensCB useChronic cannabis usersNAc connectivityHealthy controlsGlutamatergic signalingMRI studiesAnimal studiesCurrent preliminary studyLarger sample sizeMagnetic resonance spectroscopyFunctional connectivityHeavy cannabisCannabis usersCannabisReward networkCB usersLinear regression modelsRSFCEffect sizeIndividuals with psychosis and a lifetime history of cannabis use show greater deficits in emotional experience compared to non-using peers
Martin A, Lysaker PH. Individuals with psychosis and a lifetime history of cannabis use show greater deficits in emotional experience compared to non-using peers. Journal Of Mental Health 2019, 29: 77-83. PMID: 30822177, DOI: 10.1080/09638237.2018.1487540.Peer-Reviewed Original ResearchMeSH KeywordsAdultEmotionsFemaleHumansMaleMarijuana SmokingMiddle AgedPeer GroupPsychotic DisordersSchizophrenic PsychologySelf ReportConceptsEmotional Expressivity ScaleEmotional experienceSocial Functioning ScaleEmotional expressionAnticipatory pleasureLifetime cannabisSocial functioningGreater deficitsSocial functionCannabis useNon-using peersAnticipation of pleasureExperience of pleasurePoor social functionEmotional expressivityLifetime historyAnticipatory anhedoniaProsocial activitiesActive cannabisPleasure ScaleTemporal experienceHistory of cannabisFunctioning ScaleEarly psychosisPrevious research
2017
The positive link between executive function and lifetime cannabis use in schizophrenia is not explained by current levels of superior social cognition
Helle S, Løberg EM, Gjestad R, Martin A, Lysaker PH. The positive link between executive function and lifetime cannabis use in schizophrenia is not explained by current levels of superior social cognition. Psychiatry Research 2017, 250: 92-98. PMID: 28152399, DOI: 10.1016/j.psychres.2017.01.047.Peer-Reviewed Original ResearchConceptsSocial cognitionTheory of mindExecutive functionCannabis useBell-Lysaker Emotion Recognition TestEmotion Recognition TestExecutive Functioning ScaleBetter executive functionRegular cannabis useStructural equation modelingHinting testIllicit substancesNeurocognitive vulnerabilityRecognition testNeurocognitive performanceNeurocognitive deficitsCognitionEquation modelingFlexibility componentsAlcohol useFunctioning ScaleLifetime cannabisIndirect effectsPositive linkSchizophrenia
2011
The safety of studies with intravenous Δ9-tetrahydrocannabinol in humans, with case histories
Carbuto M, Sewell RA, Williams A, Forselius-Bielen K, Braley G, Elander J, Pittman B, Schnakenberg A, Bhakta S, Perry E, Ranganathan M, D’Souza D, The Yale THC Study Group. The safety of studies with intravenous Δ9-tetrahydrocannabinol in humans, with case histories. Psychopharmacology 2011, 219: 885-896. PMID: 21845389, DOI: 10.1007/s00213-011-2417-y.Peer-Reviewed Original ResearchConceptsAdverse eventsPost-study periodCareful subject selectionMinor adverse eventsPhysical adverse eventsFrequent side effectsLong-term followCannabinoid receptor systemFaster infusion rateCannabinoid receptor ligandsIntravenous THCPlacebo infusionCannabinoid systemInfusion rateStudy participationSide effectsAbuse liabilityHigh dosesReceptor systemΔ9-tetrahydrocannabinolInfusionPsychoactive effectsReceptor ligandsTest daySubjects