2023
Preliminary study of the interactive effects of THC and ethanol on self-reported ability and simulated driving, subjective effects, and cardiovascular responses
Schnakenberg Martin A, Flynn L, Sefik E, Luddy C, Cortes-Briones J, Skosnik P, Pittman B, Ranganathan M, D’Souza D. Preliminary study of the interactive effects of THC and ethanol on self-reported ability and simulated driving, subjective effects, and cardiovascular responses. Psychopharmacology 2023, 240: 1235-1246. PMID: 37045988, DOI: 10.1007/s00213-023-06356-0.Peer-Reviewed Original ResearchMeSH KeywordsAutomobile DrivingDouble-Blind MethodDronabinolEthanolHallucinogensHumansPsychomotor PerformanceSelf ReportConceptsSubjective effectsOral tetrahydrocannabinolSelf-reported abilityEffects of cannabisInfluence of tetrahydrocannabinolCause of morbiditySimulated drivingFeeling statesBlood alcohol levelsMotor vehicle accidentsAlcohol-related motor vehicle accidentsCardiovascular responsesIntravenous ethanolHealthy humansHeart rateVehicle accidentsAlcohol levelsInteractive effectsTetrahydrocannabinolPhysiological effectsSignificant differencesDrivingAbilityPreliminary studyRationaleDrug
2022
The relationship between cannabis use and taurine: A MRS and metabolomics study
Newman S, Martin A, Raymond D, Cheng H, Wilson L, Barnes S, O’Donnell B. The relationship between cannabis use and taurine: A MRS and metabolomics study. PLOS ONE 2022, 17: e0269280. PMID: 35653401, PMCID: PMC9162360, DOI: 10.1371/journal.pone.0269280.Peer-Reviewed Original ResearchConceptsTaurine levelsCB useBody compositionLow-BMI individualsDorsal anterior cingulateMagnetic resonance spectroscopyNon-user groupNeuroprotective effectsBMI individualsNeurotoxic effectsMRS studiesUrine analysisAnterior cingulateCannabis useSimilar findingsUrine samplesTaurineEssential amino acidsMetabolomic analysisMetabolomics studiesGlutamateCurrent studyGroupBMILevelsDelta-9-Tetrahydrocannabinol, Cannabidiol, and Acute Psychotomimetic States: A Balancing Act of the Principal Phyto-Cannabinoids on Human Brain and Behavior
Ganesh S, Cortes-Briones J, Martin A, Skosnik PD, D'Souza DC, Ranganathan M. Delta-9-Tetrahydrocannabinol, Cannabidiol, and Acute Psychotomimetic States: A Balancing Act of the Principal Phyto-Cannabinoids on Human Brain and Behavior. Cannabis And Cannabinoid Research 2022, 8: 846-856. PMID: 35319274, PMCID: PMC10589482, DOI: 10.1089/can.2021.0166.Peer-Reviewed Original ResearchConceptsPsychotomimetic effectsHuman laboratory studiesDifferent dose ratiosDose-related interactionDelta-9-TetrahydrocannabinolLower CBDNeural noiseRatio-dependent mannerCannabis liberalizationHealthy volunteersElectrophysiological biomarkersMedical indicationsPsychotomimetic statesSpecific brainDose ratioPrior exposureObjective effectsHuman brainMaximal attenuationBrainTHCAntagonistic effectCannabis plantNeuroscience investigationsBehavioral responses
2012
Dose-Related Behavioral, Subjective, Endocrine, and Psychophysiological Effects of the κ Opioid Agonist Salvinorin A in Humans
Ranganathan M, Schnakenberg A, Skosnik PD, Cohen BM, Pittman B, Sewell RA, D'Souza DC. Dose-Related Behavioral, Subjective, Endocrine, and Psychophysiological Effects of the κ Opioid Agonist Salvinorin A in Humans. Biological Psychiatry 2012, 72: 871-879. PMID: 22817868, PMCID: PMC3638802, DOI: 10.1016/j.biopsych.2012.06.012.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, InhalationAdultCardiovascular SystemCognitionCross-Over StudiesDiterpenes, ClerodaneDose-Response Relationship, DrugDrug MonitoringElectroencephalographyEuphoriaFemaleHallucinogensHumansHydrocortisoneIllicit DrugsMalePerceptionProlactinPsychiatric Status Rating ScalesPsychoses, Substance-InducedReceptors, Opioid, kappaSensationConceptsSA administrationSalvinorin APopular recreational drugElectroencephalogram spectral powerPrimary active ingredientPsychotomimetic effectsReceptor agonismOpiate receptorsEndocrine effectsHealthy subjectsSelective agonistHealthy individualsPerceptual alterationsPlasma cortisolEuphoric effectsCognitive deficitsRecreational drugsVital signsCounterbalanced studyEffect of SAYoung adultsAdverse effectsPsychophysiological effectsIndividual variabilityAdministration