2017
Acute Phencyclidine Alters Neural Oscillations Evoked by Tones in the Auditory Cortex of Rats
Martin A, OʼDonnell BF, Millward JB, Vohs JL, Leishman E, Bolbecker AR, Rass O, Morzorati SL. Acute Phencyclidine Alters Neural Oscillations Evoked by Tones in the Auditory Cortex of Rats. Neuropsychobiology 2017, 75: 53-62. PMID: 29065422, PMCID: PMC5752597, DOI: 10.1159/000480511.Peer-Reviewed Original ResearchConceptsAcute PCPSubchronic administrationAuditory cortexN-methyl-D-aspartate (NMDA) receptor systemGamma range frequenciesPathophysiology of schizophreniaGamma range activityEffects of PCPN70 componentsAcute administrationDrug cessationEvent-related potentialsNMDAR hypofunctionNMDAR antagonistsTranslational biomarkersNMDAR functionBACKGROUND/EEG spectral powerOnset responsePCP doseMean powerNeuropsychiatric disordersReceptor systemNeural powerSimilar deficits
2011
The safety of studies with intravenous Δ9-tetrahydrocannabinol in humans, with case histories
Carbuto M, Sewell RA, Williams A, Forselius-Bielen K, Braley G, Elander J, Pittman B, Schnakenberg A, Bhakta S, Perry E, Ranganathan M, D’Souza D, The Yale THC Study Group. The safety of studies with intravenous Δ9-tetrahydrocannabinol in humans, with case histories. Psychopharmacology 2011, 219: 885-896. PMID: 21845389, DOI: 10.1007/s00213-011-2417-y.Peer-Reviewed Original ResearchConceptsAdverse eventsPost-study periodCareful subject selectionMinor adverse eventsPhysical adverse eventsFrequent side effectsLong-term followCannabinoid receptor systemFaster infusion rateCannabinoid receptor ligandsIntravenous THCPlacebo infusionCannabinoid systemInfusion rateStudy participationSide effectsAbuse liabilityHigh dosesReceptor systemΔ9-tetrahydrocannabinolInfusionPsychoactive effectsReceptor ligandsTest daySubjects