1998
Regulation of Cardiac Myocyte Contractile Function by Inducible Nitric Oxide Synthase (iNOS): Mechanisms of Contractile Depression by Nitric Oxide
Joe E, Schussheim A, Longrois D, Mäki T, Kelly R, Smith T, Balligand J. Regulation of Cardiac Myocyte Contractile Function by Inducible Nitric Oxide Synthase (iNOS): Mechanisms of Contractile Depression by Nitric Oxide. Journal Of Molecular And Cellular Cardiology 1998, 30: 303-315. PMID: 9515007, DOI: 10.1006/jmcc.1997.0593.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthineAcetylcysteineAdenylyl CyclasesAdrenergic beta-AgonistsAnimalsCulture Media, ConditionedCyclic AMPCyclic GMPEnzyme InductionGTP-Binding ProteinsIn Vitro TechniquesIsoproterenolLipopolysaccharidesMacrophages, AlveolarMyocardial ContractionNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IIPhosphodiesterase InhibitorsRatsRats, Sprague-DawleyConceptsInducible nitric oxide synthaseInduction of iNOSBeta-adrenergic stimulationMacrophage-conditioned mediumNM IsoCardiac myocytesContractile responseContractile functionBeta-adrenergic receptor densityNitric oxideMyocyte contractile functionSystemic immune stimulationCardiac contractile functionNitric oxide synthaseCardiac myocyte contractile functionRat lung macrophagesAdenylyl cyclase activityCultured ventricular myocytesContractile depressionNOS inhibitionAdrenergic responsivenessInflammatory cytokinesElevation of cAMPCardiac functionNOS inhibitor
1997
Usefulness of Subnormal Midwall Fractional Shortening in Predicting Left Ventricular Exercise Dysfunction in Asymptomatic Patients With Systemic Hypertension
Schussheim A, Devereux R, de Simone G, Borer J, Herrold E, Laragh J. Usefulness of Subnormal Midwall Fractional Shortening in Predicting Left Ventricular Exercise Dysfunction in Asymptomatic Patients With Systemic Hypertension. The American Journal Of Cardiology 1997, 79: 1070-1074. PMID: 9114766, DOI: 10.1016/s0002-9149(97)00049-0.Peer-Reviewed Original ResearchConceptsMidwall fractional shorteningAsymptomatic hypertensive patientsLV ejection fractionFractional shorteningBlood pressureHypertensive patientsEjection fractionHigher mean diastolic blood pressureExtracardiac target organ damageHigher urinary protein excretionLower midwall fractional shorteningMean diastolic blood pressureLV functional reserveSerum creatinine levelsTarget organ damageUrinary protein excretionDiastolic blood pressureSystolic blood pressureHigher LV massBody mass indexIdentification of patientsExercise dysfunctionAsymptomatic patientsSystemic hypertensionCreatinine levels
1993
Cardiac nuclear magnetic resonance spectroscopy
Schussheim A, Kantor H. Cardiac nuclear magnetic resonance spectroscopy. Coronary Artery Disease 1993, 4: 361-370. PMID: 8261209, DOI: 10.1097/00019501-199304000-00008.Peer-Reviewed Original Research