Featured Publications
Impact of Cardiovascular Risk on the Relative Benefit and Harm of Intensive Treatment of Hypertension
Phillips RA, Xu J, Peterson LE, Arnold RM, Diamond JA, Schussheim AE. Impact of Cardiovascular Risk on the Relative Benefit and Harm of Intensive Treatment of Hypertension. Journal Of The American College Of Cardiology 2018, 71: 1601-1610. PMID: 29525494, DOI: 10.1016/j.jacc.2018.01.074.Peer-Reviewed Original ResearchConceptsSignificant serious adverse eventsPrimary outcome eventIntensive treatment groupCVD riskOutcome eventsHarm ratioIntensive treatmentTreatment groupsTreatment guidelinesAmerican CollegeCardiology/American Heart AssociationFuture cardiovascular disease riskCox proportional hazards modelBaseline CVD riskQuartiles of baselineSerious adverse eventsBlood pressure treatmentCardiovascular disease riskAmerican Heart AssociationProportional hazards modelLower ratesSPRINT populationAdverse eventsCardiovascular riskPrimary outcome
2011
Dipyridamole-Associated Shock and Pulmonary Edema
Dioverti M, Fishman R, Moskowitz R, Arias SA, Nair S, Lall P, Schussheim AE, Zarich S, Manthous C. Dipyridamole-Associated Shock and Pulmonary Edema. Annals Of Pharmacotherapy 2011, 45: 1027-1027. PMID: 21672887, DOI: 10.1345/aph.1p734.Peer-Reviewed Original ResearchConceptsNoncardiogenic pulmonary edemaDipyridamole myocardial scintigraphyPulmonary edemaSevere pulmonary edemaCardiopulmonary collapseMyocardial scintigraphyNew left ventricular dysfunctionPositive end-expiratory pressureObjective causality assessmentLeft ventricular dysfunctionEnd-expiratory pressureMechanism of shockFulminant shockInvasive ventilationMultiple vasopressorsCardiovascular collapseHypovolemic shockShock refractoryCase seriesDipyridamole infusionEchocardiography resultsEndotracheal intubationIntravenous dipyridamoleContinuous infusionIntravenous infusion
2003
Detecting Acute Coronary Syndrome in the Emergency Department With Cardiac Magnetic Resonance Imaging
Kwong RY, Schussheim AE, Rekhraj S, Aletras AH, Geller N, Davis J, Christian TF, Balaban RS, Arai AE. Detecting Acute Coronary Syndrome in the Emergency Department With Cardiac Magnetic Resonance Imaging. Circulation 2003, 107: 531-537. PMID: 12566362, DOI: 10.1161/01.cir.0000047527.11221.29.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedAngina, UnstableChest PainCoronary DiseaseDiagnosis, DifferentialElectrocardiographyEmergency Service, HospitalFemaleFollow-Up StudiesHumansLikelihood FunctionsLogistic ModelsMagnetic Resonance ImagingMaleMiddle AgedMyocardial InfarctionPredictive Value of TestsProspective StudiesROC CurveSensitivity and SpecificityTroponinConceptsAcute coronary syndromeStrict ECG criteriaTIMI risk scoreCoronary syndromeChest painEmergency departmentPeak troponinAbnormal ECGRisk scoreECG criteriaProbable acute coronary syndromeCardiac MRIMultivariate logistic regression analysisCardiac magnetic resonance imagingDiagnostic operating characteristicsHours of presentationTriage of patientsAcute myocardial infarctionLogistic regression analysisCurrent diagnostic strategiesMagnetic resonance imagingUnstable anginaConsecutive patientsVentricular functionClinical parameters
1998
Midwall fractional shortening is an independent predictor of left ventricular diastolic dysfunction in asymptomatic patients with systemic hypertension
Schussheim A, Diamond J, Jhang J, Phillips R. Midwall fractional shortening is an independent predictor of left ventricular diastolic dysfunction in asymptomatic patients with systemic hypertension. The American Journal Of Cardiology 1998, 82: 1056-1059. PMID: 9817481, DOI: 10.1016/s0002-9149(98)00558-x.Peer-Reviewed Original ResearchConceptsMidwall fractional shorteningAbnormal diastolic functionMidwall shorteningHypertensive patientsSystolic functionDiastolic functionFractional shorteningDiastolic dysfunctionBlood pressureIndependent predictorsSystolic performanceEndocardial shorteningFiber shorteningLeft ventricular systolic performanceDepressed midwall shorteningHealthy hypertensive patientsLV diastolic abnormalitiesLV inflow velocityNormal midwall shorteningTarget organ damageVentricular diastolic dysfunctionIsovolumic relaxation timeLV systolic functionHigh blood pressureVentricular systolic performance
1997
Usefulness of Subnormal Midwall Fractional Shortening in Predicting Left Ventricular Exercise Dysfunction in Asymptomatic Patients With Systemic Hypertension
Schussheim A, Devereux R, de Simone G, Borer J, Herrold E, Laragh J. Usefulness of Subnormal Midwall Fractional Shortening in Predicting Left Ventricular Exercise Dysfunction in Asymptomatic Patients With Systemic Hypertension. The American Journal Of Cardiology 1997, 79: 1070-1074. PMID: 9114766, DOI: 10.1016/s0002-9149(97)00049-0.Peer-Reviewed Original ResearchConceptsMidwall fractional shorteningAsymptomatic hypertensive patientsLV ejection fractionFractional shorteningBlood pressureHypertensive patientsEjection fractionHigher mean diastolic blood pressureExtracardiac target organ damageHigher urinary protein excretionLower midwall fractional shorteningMean diastolic blood pressureLV functional reserveSerum creatinine levelsTarget organ damageUrinary protein excretionDiastolic blood pressureSystolic blood pressureHigher LV massBody mass indexIdentification of patientsExercise dysfunctionAsymptomatic patientsSystemic hypertensionCreatinine levels