2022
PDE4DIP in health and diseases
Mani A. PDE4DIP in health and diseases. Cellular Signalling 2022, 94: 110322. PMID: 35346821, PMCID: PMC9618167, DOI: 10.1016/j.cellsig.2022.110322.Peer-Reviewed Original ResearchConceptsSecond messengerClass of enzymesCyclic AMPRecent genetic studiesSpecific cell functionsAnchoring proteinsDynamic microdomainsPathological cardiac remodelingExcitation-contraction couplingIntracellular targetingSpecific proteinsGenetic studiesCell survivalIntracellular messengerStimulating pathwaysCAMP-dependent phosphodiesteraseHeart failureDiverse classAtrial fibrillationCardiac remodelingInjury resultsPredominant isoformFunction of organsConduction velocityHeart rate
2020
The role of Wnt signalling in development of coronary artery disease and its risk factors
Liu Y, Neogi A, Mani A. The role of Wnt signalling in development of coronary artery disease and its risk factors. Open Biology 2020, 10: 200128. PMID: 33081636, PMCID: PMC7653355, DOI: 10.1098/rsob.200128.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBiomarkersCarrier ProteinsCell DifferentiationCell MovementCoronary Artery DiseaseDisease SusceptibilityEndotheliumGene Expression RegulationHumansLipid MetabolismMacrophage ActivationMacrophagesMyocytes, Smooth MuscleProtein BindingRisk FactorsWnt ProteinsWnt Signaling PathwayConceptsCoronary artery diseaseArtery diseaseRole of WntVascular smooth muscle cellsEndothelial cell dysfunctionReduced blood flowLow-density lipoproteinModified low-density lipoproteinWnt pathwaySmooth muscle cellsNon-canonical Wnt/CaAggregation of monocytesTissue-resident macrophagesChest painEndothelial dysfunctionWnt/CaHeart failureLuminal narrowingCascade of eventsPathophysiological mechanismsMyocardial infarctionRisk factorsHeart diseaseCell dysfunctionInflammatory reaction
2015
The Genetic Challenges and Opportunities in Advanced Heart Failure
Hannah-Shmouni F, Seidelmann SB, Sirrs S, Mani A, Jacoby D. The Genetic Challenges and Opportunities in Advanced Heart Failure. Canadian Journal Of Cardiology 2015, 31: 1338-1350. PMID: 26518444, PMCID: PMC5423787, DOI: 10.1016/j.cjca.2015.07.735.Books
2014
Plasma Cardiotrophin‐1 Levels are Associated With Hypertensive Heart Disease: A Meta‐Analysis
Song K, Wang S, Huang B, Luciano A, Srivastava R, Mani A. Plasma Cardiotrophin‐1 Levels are Associated With Hypertensive Heart Disease: A Meta‐Analysis. Journal Of Clinical Hypertension 2014, 16: 686-692. PMID: 25052897, PMCID: PMC4159421, DOI: 10.1111/jch.12376.Peer-Reviewed Original ResearchConceptsCT-1 levelsPlasma CT-1 levelsHypertensive heart diseaseHeart failureLeft ventricular hypertrophyVentricular hypertrophyCardiotrophin-1Hypertensive patientsHeart diseaseHypertension-induced left ventricular hypertrophyCardiotrophin-1 levelsSmall independent studiesHypertension-induced hypertrophyInterleukin-6 cytokineNormotensive patientsSerum levelsSubgroup analysisCardiac hypertrophyNovel biomarkersHypertensionPatientsElectronic databasesHypertrophyMeta-AnalysisStandardized algorithm