2024
Comparative Effectiveness of Second-Line Antihyperglycemic Agents for Cardiovascular Outcomes A Multinational, Federated Analysis of LEGEND-T2DM
Khera R, Aminorroaya A, Dhingra L, Thangaraj P, Pedroso Camargos A, Bu F, Ding X, Nishimura A, Anand T, Arshad F, Blacketer C, Chai Y, Chattopadhyay S, Cook M, Dorr D, Duarte-Salles T, DuVall S, Falconer T, French T, Hanchrow E, Kaur G, Lau W, Li J, Li K, Liu Y, Lu Y, Man K, Matheny M, Mathioudakis N, McLeggon J, McLemore M, Minty E, Morales D, Nagy P, Ostropolets A, Pistillo A, Phan T, Pratt N, Reyes C, Richter L, Ross J, Ruan E, Seager S, Simon K, Viernes B, Yang J, Yin C, You S, Zhou J, Ryan P, Schuemie M, Krumholz H, Hripcsak G, Suchard M. Comparative Effectiveness of Second-Line Antihyperglycemic Agents for Cardiovascular Outcomes A Multinational, Federated Analysis of LEGEND-T2DM. Journal Of The American College Of Cardiology 2024, 84: 904-917. PMID: 39197980, DOI: 10.1016/j.jacc.2024.05.069.Peer-Reviewed Original ResearchConceptsGLP-1 RAsSecond-line agentsGLP-1Antihyperglycemic agentsCardiovascular diseaseMACE riskGlucagon-like peptide-1 receptor agonistsSodium-glucose cotransporter 2 inhibitorsPeptide-1 receptor agonistsDipeptidyl peptidase-4 inhibitorsEffects of SGLT2isType 2 diabetes mellitusPeptidase-4 inhibitorsAdverse cardiovascular eventsCox proportional hazards modelsRandom-effects meta-analysisCardiovascular risk reductionTarget trial emulationProportional hazards modelPerformance of contemporary cardiovascular risk stratification scores in Brazil: an evaluation in the ELSA-Brasil study
Camargos A, Barreto S, Brant L, Ribeiro A, Dhingra L, Aminorroaya A, Bittencourt M, Figueiredo R, Khera R. Performance of contemporary cardiovascular risk stratification scores in Brazil: an evaluation in the ELSA-Brasil study. Open Heart 2024, 11: e002762. PMID: 38862252, PMCID: PMC11168182, DOI: 10.1136/openhrt-2024-002762.Peer-Reviewed Original ResearchConceptsPooled Cohort EquationsELSA-BrasilRisk scoreCardiovascular diseaseCVD eventsCommunity-based cohort studyArea under the receiver operating characteristic curveCVD risk scoreELSA-Brasil studyIncident CVD eventsMiddle-income countriesAdjudicated CVD eventsCardiovascular disease riskCVD scoreCohort EquationsNational guidelinesRisk stratification scoresWhite womenAge/sex groupsCohort studyProspective cohortLMICsSex/race groupsHigher incomeRisk discriminationBurden of Ischemic Heart Disease and Its Attributable Risk Factors in North Africa and the Middle East, 1990 to 2019: Results From the GBD Study 2019
Aminorroaya A, Moghaddam S, Tavolinejad H, Aryan Z, Heidari B, Ebrahimi H, Naderian M, Shobeiri P, Ghanbari A, Rezaei N, Malekpour M, Haghshenas R, Rezaei N, Larijani B, Farzadfar F. Burden of Ischemic Heart Disease and Its Attributable Risk Factors in North Africa and the Middle East, 1990 to 2019: Results From the GBD Study 2019. Journal Of The American Heart Association 2024, 13: e030165. PMID: 37956220, PMCID: PMC10926818, DOI: 10.1161/jaha.123.030165.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsBurden of ischemic heart diseaseDisability-adjusted life year ratesRates of ischemic heart diseaseIschemic heart diseaseRisk factorsMortality of ischemic heart diseaseEpidemiology of ischemic heart diseaseIschemic heart disease burdenHigh low-density lipoprotein cholesterolDietary risk factorsLost disability-adjusted life yearsYears of lifeHeart diseaseGBD studyPremature mortalityLow-density lipoprotein cholesterolSystolic blood pressureHighest burdenMetabolic riskBehavioral risksLife yearsPremature deathContemporary epidemiologyLipoprotein cholesterol
2023
Risk of incident cardiovascular diseases at national and subnational levels in Iran from 2000 to 2016 and projection through 2030: Insights from Iran STEPS surveys
Ebrahimi H, Masinaei M, Aminorroaya A, Aryan Z, Mehdipour P, Rostam-Abadi Y, Ahmadi N, Moghaddam S, Pishgar F, Ghanbari A, Rezaei N, Takian A, Farzadfar F. Risk of incident cardiovascular diseases at national and subnational levels in Iran from 2000 to 2016 and projection through 2030: Insights from Iran STEPS surveys. PLOS ONE 2023, 18: e0290006. PMID: 37611004, PMCID: PMC10446220, DOI: 10.1371/journal.pone.0290006.Peer-Reviewed Original ResearchConceptsCardiovascular disease riskRisk of cardiovascular diseaseNon-communicable disease risk factor surveillanceCardiovascular diseaseCVD riskWorld Health OrganizationRisk of incident cardiovascular diseaseRisk factor surveillanceFramingham 10-year CVD riskAdult Iranian populationIncident cardiovascular diseaseRisk factor modificationCardiovascular disease risk stratificationEvidence-based decisionsFramingham modelHealth policyNationally representative datasetFactor modificationRisk estimation modelIranian populationHealth OrganizationFraminghamSurvey's backgroundRiskSubnational levelUse of Wearable Devices in Individuals With or at Risk for Cardiovascular Disease in the US, 2019 to 2020
Dhingra L, Aminorroaya A, Oikonomou E, Nargesi A, Wilson F, Krumholz H, Khera R. Use of Wearable Devices in Individuals With or at Risk for Cardiovascular Disease in the US, 2019 to 2020. JAMA Network Open 2023, 6: e2316634. PMID: 37285157, PMCID: PMC10248745, DOI: 10.1001/jamanetworkopen.2023.16634.Peer-Reviewed Original ResearchConceptsHealth Information National Trends SurveyUS adultsExacerbate disparitiesWearable device usersCardiovascular diseaseCardiovascular healthPopulation-based cross-sectional studySelf-reported cardiovascular diseaseCardiovascular disease risk factorsNational Trends SurveyOverall US adult populationCardiovascular risk factor profileSelf-reported accessAssociated with lower useUse of wearable devicesImprove cardiovascular healthLower household incomeLower educational attainmentUS adult populationRisk factor profileNationally representative sampleCross-sectional studyProportion of adultsTrends SurveyWearable device dataPersistence on Novel Cardioprotective Antihyperglycemic Therapies in the United States
Nargesi A, Clark C, Aminorroaya A, Chen L, Liu M, Reddy A, Amodeo S, Oikonomou E, Suchard M, McGuire D, Lin Z, Inzucchi S, Khera R. Persistence on Novel Cardioprotective Antihyperglycemic Therapies in the United States. The American Journal Of Cardiology 2023, 196: 89-98. PMID: 37012183, PMCID: PMC11007258, DOI: 10.1016/j.amjcard.2023.03.002.Peer-Reviewed Original ResearchConceptsSGLT-2iGLP-1RAsGlucagon-like peptide-1 receptor agonistsUnited States administrative claims databasesSodium-glucose cotransporter 2 inhibitorsCommercial insurancePeptide-1 receptor agonistsType 2 diabetes mellitusSodium-glucose cotransporter-2 inhibitorsConsistent medication useHealth outcome benefitsCotransporter 2 inhibitorsElevated cardiovascular riskInitiation of therapyAdministrative claims databaseProportion of daysCotransporter-2 inhibitorsRate of prescriptionAntihyperglycemic therapyCardiovascular riskDiabetes mellitusMedication useCardioprotective effectsPrescription practicesClaims databaseNovel DNMT3B Mutation in a Patient with Immunodeficiency, Centromeric Instability, and Facial Anomalies (ICF) Syndrome and a Bronchopulmonary Collateral Artery
Esmaeilzadeh H, Rezaei N, Aminorroaya A, Rayzan E, Shahkarami S, Seyedpour S, Zoghi S, Aryan Z, Somekh I, Rohlfs M, Klein C. Novel DNMT3B Mutation in a Patient with Immunodeficiency, Centromeric Instability, and Facial Anomalies (ICF) Syndrome and a Bronchopulmonary Collateral Artery. Endocrine Metabolic & Immune Disorders - Drug Targets 2023, 23: 410-415. PMID: 35996251, DOI: 10.2174/1871530322666220822141722.Peer-Reviewed Original ResearchConceptsRecurrent respiratory infectionsFacial anomaliesDNMT3B mutationsRecurrent infectionsCollateral arteriesFamily historyRespiratory infectionsHistory of recurrent respiratory infectionsAssociated with recurrent infectionsCentromeric instabilityFamily history of consanguinityRare autosomal recessive disorderRecurrent episodes of pneumoniaMonthly intravenous immunoglobulinProphylactic trimethoprim-sulfamethoxazolePrimary immune deficiencyBone marrow studyLow-set earsPatent ductus arteriosusEvaluation of neutropeniaEpisodes of pneumoniaHistory of consanguinityMild facial anomaliesAutosomal recessive disorderSystolic cardiac murmur
2022
Clinical Associations of Injuries Caused by Vasovagal Syncope: A Cohort Study From a Tertiary Syncope Unit
Tajdini M, Tavolinejad H, Aminorroaya A, Aryan Z, Jalali A, Alaeddini F, Sadeghian S, Yadangi S, Vasheghani‐Farahani A, Kalhor P, Bozorgi A. Clinical Associations of Injuries Caused by Vasovagal Syncope: A Cohort Study From a Tertiary Syncope Unit. Journal Of The American Heart Association 2022, 12: e027272. PMID: 36565190, PMCID: PMC9973565, DOI: 10.1161/jaha.122.027272.Peer-Reviewed Original ResearchConceptsAssociation of injuryIncidence of injuryAssociated with injuryVasovagal syncopeClinical associationsRate of injuryAssociated with lower riskRisk of injuryAt-risk individualsAbsence of prodromesRecurrent vasovagal syncopeYears of ageStanding positionCohort studySyncope clinicHigh-risk situationsRecurrent casesFemale sexProspective studyPatient characteristicsClinical evaluationSyncopeSyncope unitLow riskInjuryPharmacologic prevention of recurrent vasovagal syncope: A systematic review and network meta-analysis of randomized controlled trials
Behnoush A, Yazdani K, Khalaji A, Tavolinejad H, Aminorroaya A, Jalali A, Tajdini M. Pharmacologic prevention of recurrent vasovagal syncope: A systematic review and network meta-analysis of randomized controlled trials. Heart Rhythm 2022, 20: 448-460. PMID: 36509319, DOI: 10.1016/j.hrthm.2022.12.010.Peer-Reviewed Original ResearchConceptsHead-up tilt testPositive head-up tilt testNetwork meta-analysisRandomized controlled trialsVasovagal syncopeMeta-analysisPharmacological therapyPrimary outcomeRisk ratioRandom-effects network meta-analysisSystematic reviewPooled risk ratioConfidence intervalsHealth care systemLevel of evidenceCumulative ranking curve analysisPairwise meta-analysisTreatment optionsWeb of ScienceSyncopal eventsTilt testCare systemComparative efficacySecondary outcomesCochrane LibraryToll-like receptor 7 regulates cardiovascular diseases
Shafeghat M, Kazemian S, Aminorroaya A, Aryan Z, Rezaei N. Toll-like receptor 7 regulates cardiovascular diseases. International Immunopharmacology 2022, 113: 109390. PMID: 36330918, DOI: 10.1016/j.intimp.2022.109390.Peer-Reviewed Original ResearchConceptsTLR-7Toll-like receptorsIncreased risk of complete heart blockRisk of complete heart blockGranulocyte-macrophage colony-stimulating factorTLR-7 activationTLR-7 ligandsVascular smooth muscle cellsComplete heart blockImmune system's roleLeft ventricular remodelingColony-stimulating factorDamage-associated molecular patternsSmooth muscle cellsInnate immune receptorsPro-inflammatory natureRisk of thrombus formationHeart blockImmune cellsVentricular remodelingIncreased riskMuscle cellsAtherosclerotic plaque formationSingle-stranded ribonucleic acidViral infectionAssociation of Opium Consumption and Coronary Artery Ectasia: A Propensity Score-Matched Study
Shafie M, Aminorroaya A, Vasheghani-Farahani A, Jalali A, Baradaran A. Association of Opium Consumption and Coronary Artery Ectasia: A Propensity Score-Matched Study. Archives Of Iranian Medicine 2022, 25: 542-546. PMID: 37543876, DOI: 10.34172/aim.2022.86.Peer-Reviewed Original ResearchConceptsCoronary artery ectasiaCoronary artery diseaseOpium consumptionArtery ectasiaArtery diseaseFamily history of coronary artery diseaseCoronary artery ectasia groupDevelopment of coronary artery ectasiaHistory of coronary artery diseasePrevalence of opium consumptionAssociated with increased riskAssociated with increased risk of atherosclerosisElective coronary angiographyIndependent risk factorControl groupScore-matched studyHyper-inflammatory stateTehran Heart CenterRisk of atherosclerosisNon-consumersFamily historyNo significant differenceCoronary angiographyControl patientsHeart CenterEpidemiology, burden, and attributable risks of infective endocarditis in Iran and its provinces: From 1990 to 2019
Ajam A, Shobeiri P, Keykhaei M, Moghaddam S, Momtazmanesh S, Masinaei M, Esfahani Z, Rezaei N, Naderian M, Aminorroaya A, Rashidi M, Rezaei N, Larijani B, Malakan Rad E, Farzadfar F. Epidemiology, burden, and attributable risks of infective endocarditis in Iran and its provinces: From 1990 to 2019. International Journal Of Cardiology 2022, 363: 202-209. PMID: 35777487, DOI: 10.1016/j.ijcard.2022.06.060.Peer-Reviewed Original ResearchConceptsAge-standardized mortality ratesAge-standardized incidence rateAge-standardized prevalence rateDisability-adjusted life yearsAge-standardized DALY rateMortality rateInfectious disease associated with significant morbidityDALY ratesRisk of infective endocarditisDisease associated with significant morbidityGlobal burdenIncidence rateLife yearsPrevalence ratesEscalating incidenceAge groupsStudy dataInfective endocarditisEpidemiological indicesBurdenSignificant morbidityGBDEndocarditisMortalityProvincial levelRheumatic Heart Disease Is a Neglected Disease Relative to Its Burden Worldwide: Findings From Global Burden of Disease 2019
Ghamari S, Abbasi‐Kangevari M, Moghaddam S, Aminorroaya A, Rezaei N, Shobeiri P, Esfahani Z, Malekpour M, Rezaei N, Ghanbari A, Keykhaei M, Naderian M, Larijani B, Majnoon M, Farzadfar F, Mokdad A. Rheumatic Heart Disease Is a Neglected Disease Relative to Its Burden Worldwide: Findings From Global Burden of Disease 2019. Journal Of The American Heart Association 2022, 11: e025284. PMID: 35730651, PMCID: PMC9333364, DOI: 10.1161/jaha.122.025284.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsRheumatic heart diseaseAge-standardized incidenceAge-standardized deathBirth cohort effectsSociodemographic indexRheumatic heart disease burdenLife yearsPrevalence ratesCohort effectsHighest age-standardized incidenceAge-standardized disability-adjusted life yearsAge-period-cohort analysisDisability-adjusted life year ratesGlobal Burden of DiseasePrevalence rate of rheumatic heart diseaseHeart diseaseMiddle-income countriesSociodemographic index levelsBurden of diseaseBurden of rheumatic heart diseaseRate of rheumatic heart diseaseIncidence of rheumatic heart diseaseCountry's sociodemographic indexAssess inequalitiesGlobal and regional burden and quality of care of non-rheumatic valvular heart diseases: a systematic analysis of Global Burden of Disease 1990–2017
Nejad M, Ahmadi N, Mohammadi E, Shabani M, Sherafati A, Aryannejad A, Rezaei N, Ghanbari A, Yoosefi M, Aminorroaya A, Shabani M, Rezaei N, Salavati T, Larijani B, Naderimagham S, Farzadfar F. Global and regional burden and quality of care of non-rheumatic valvular heart diseases: a systematic analysis of Global Burden of Disease 1990–2017. International Journal For Quality In Health Care 2022, 34: mzac026. PMID: 35434737, DOI: 10.1093/intqhc/mzac026.Peer-Reviewed Original ResearchConceptsQuality of care indexGlobal Burden of DiseaseNon-rheumatic valvular heart diseaseQuality of careSociodemographic indexBurden of diseaseQuality of care index scoreLow SDI quintileWHO world regionsSociodemographic index countriesHeart diseaseHealthcare qualityHealthcare accessCare indexEastern Mediterranean RegionHealthcare systemRegional burdenGlobal burdenWestern Pacific RegionValvular heart diseaseHealthcareAge groupsQuintilePrimary measureCareCompression stockings for treating vasovagal syncope (COMFORTS-II) trial: Rationale and design of a triple-blind, multi-center, randomized controlled trial
Tavolinejad H, Poopak A, Sadeghian S, Bozorgi A, Oraii A, Mollazadeh R, Emkanjoo Z, Kiarsi M, Shahabi J, Jalali A, Alaeddini F, Ariannejad H, Yadangi S, Oraii S, Kheirkhah J, Assadianrad M, Aminorroaya A, Tajdini M. Compression stockings for treating vasovagal syncope (COMFORTS-II) trial: Rationale and design of a triple-blind, multi-center, randomized controlled trial. American Heart Journal 2022, 249: 57-65. PMID: 35405100, DOI: 10.1016/j.ahj.2022.04.002.Peer-Reviewed Original ResearchConceptsElastic compression stockingsRandomized controlled trialsVasovagal syncopeProportion of participantsCompression stockingsTriple-blindLifestyle modification recommendationsVenous returnCo-primary outcomesPatient-reported adverse effectsTreat vasovagal syncopeVasovagal syncope recurrencesDiary sheetsSecondary outcomesStudy armsReduced venous returnSyncope recurrenceTrial backgroundSyncopal episodesFollow-upClinical trialsParticipantsMulti-centerOnline randomizationRecurrenceHealth system performance in Iran: a systematic analysis for the Global Burden of Disease Study 2019
Collaborators G, Farzadfar F, Naghavi M, Sepanlou S, Moghaddam S, Dangel W, Weaver N, Aminorroaya A, Azadnajafabad S, Koolaji S, Mohammadi E, Rezaei N, Abbas J, Abbasi B, Abbasifard M, Abbasi-Kangevari M, Abbasi-Kangevari Z, Abbastabar H, Abdoli A, Abdollahi M, Abdollahzade S, Abolhassani H, Abrehdari-Tafreshi Z, Aghababaei S, Ahadinezhad B, Ahmadi A, Ahmadi S, Ahmadieh H, Akbari M, Alimohamadi Y, Alipour V, Alizade H, Alvand S, Amini S, Amiri S, Anoushirvani A, Ansari F, Arabloo J, Arab-Zozani M, Aryan Z, Aryannejad A, Asadi-Aliabadi M, Asadi-Pooya A, Asemi Z, Asgari S, Asgary S, Asghari B, Jafarabadi M, Ashrafi E, Atafar Z, Athari S, Avan A, Azadmehr A, Azami H, Azangou-Khyavy M, Azari S, Jafari A, Azarian G, Badirzadeh A, Bahrami E, Bahrami M, Barati N, Bayati M, Bazmandegan G, Behzadifar M, Bijani A, Bohlouli S, Borzouei S, Daneshpajouhnejad P, Dargahi A, Daryani A, Lahijan J, Didehdar M, Djalalinia S, Doaei S, Dorostkar F, Doshmangir L, Edraki M, Emami A, Eshrati B, Eskandarieh S, Esmaeilzadeh F, Faghani S, Fakhar, Farpour H, Farrokhpour H, Harandi M, Fereidouni M, Foroutan M, Ghafourifard M, Ghamari A, Ghamari S, Ghashghaee A, Ghassemi F, Gholami A, Gholamian A, Gholizadeh A, Goharinezhad S, Goleij P, Hadei M, Hafezi-Nejad N, Hariri S, Hasanpoor E, Hassanian-Moghaddam H, Hassanipour S, Hassankhani H, Heidari M, Heidari-Soureshjani R, Hoseini M, Hosseini M, Hosseini M, Hosseini S, Hosseinzadeh A, Hosseinzadeh M, Hoveidamanesh S, Iranpour P, Irvani S, Jaafari J, Jabbarinejad R, Jafarinia M, Jafari-Vayghan H, Jahani M, Jahanmehr N, Jalili M, Janghorban R, Javanmardi F, Joukar F, Kabir A, Kalankesh L, Kalhor R, Kamiab Z, Kamyari N, Matin B, Karimi A, Karimi S, Karyani A, Keikavoosi-Arani L, Keramati M, Keshavarz P, Keykhaei M, Khaleghi A, Khammarnia M, Khanali J, Khayamzadeh M, Khosravi S, Khosravifar M, Khosravizadeh O, Kianipour N, Kolahi A, Maali A, Mahdavi M, Maleki A, Malekpour M, Mansori K, Mansouri B, Mansournia M, Maracy M, Marjani A, Masoudi S, Masoumi S, Masoumi-Asl H, Mayeli M, Nasab E, Mehri F, Miri M, Mirmoeeni S, Mirzaei H, Mirzaei M, Mirzaei R, Mohamadkhani A, Mohammadi H, Mohammadi S, Mohammadi S, Mohammadian-Hafshejani A, Mohammadifard N, Mohammadpourhodki R, Mohseni M, Mokari A, Momtazmanesh S, Moradi A, Moradi M, Moradi Y, Moradi-Joo M, Moradpour F, Moradzadeh M, Moradzadeh R, Mosapour A, Moslehi S, Mouodi S, Naderi M, Naderifar H, Najafpour Z, Nazari J, Nejadghaderi S, Nemati-Anaraki L, Nikpoor A, Nojomi M, Noori M, Nouraei H, Nowroozi A, Oladnabi M, Kan F, Pirestani M, Pirsaheb M, Pourahmadi M, Pourchamani H, Pourjafar H, Pourshams A, Rabiee M, Rabiee N, Rafiei A, Rafiei S, Rahim F, Rahmani A, Rashedi S, Rashedi V, Rashidi A, Rashidi M, Rashidi M, Ravangard R, Rawassizadeh R, Razeghian-Jahromi I, Razeghinia M, Redford S, Rezaei M, Rezaei N, Rezaei N, Rezaei S, Aliabadi H, Rezaeian M, Rezai M, Rezapour A, Rezazadeh H, Rezazadeh-Khadem S, Rostamian M, Sadeghi E, Sadeghi E, Sadeghi M, Sadeghian R, Sadeghian S, Safarpour H, Safdarian, Safi S, Sahebazzamani M, Sahebkar A, Sahraian M, Salahi S, Salamati P, Kafil H, Sarikhani Y, Sarkhosh M, Sarveazad A, Seyed-Nezhad M, Shafaat O, Shaghaghi Z, Shahabi S, Shahin S, Shaker E, Shakiba S, Shamsi M, Shamsoddin E, Sharafi K, Sharifian S, Shaygan M, Sheikhtaheri A, Shiani A, Shirbandi K, Shirkoohi R, Shobeiri P, Shokri A, Siabani S, Sima A, Sofi-Mahmudi A, Soheili A, Soltani S, Soltani-Zangbar M, Soofi M, Tabaeian S, Tabary M, Tahamtan A, Taheri M, Taherkhani A, Tajdini M, Tavolinejad H, Tehrani-Banihashemi A, Tiyuri A, Tohidast S, Vakilian A, Tahbaz S, Vo B, Jabbari S, Yazdi-Feyzabadi V, Yousefi Z, Yousefinezhadi T, Zahir M, Moghadam T, Zamanian M, Zandian H, Zangeneh A, Zarafshan H, Zare F, Dehnavi A, Zarea K, Zarei A, Zareshahrabadi Z, Ziapour A, Zoghi S, Sarrafzadegan N, Rahimi-Movaghar V, Jamshidi H, Mokdad A, Hay S, Murray C, Khosravi A, Moradi-Lakeh M, Asadi-Lari M, Malekzadeh R, Larijani B. Health system performance in Iran: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet 2022, 399: 1625-1645. PMID: 35397236, PMCID: PMC9023870, DOI: 10.1016/s0140-6736(21)02751-3.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsNon-communicable diseasesGlobal Burden of Disease StudyBurden of diseaseDisability-adjusted life year ratesBurden of Disease StudyHealth-care systemRisk factorsGlobal burdenAge-standardised DALY ratesHealth system performanceCause-specific mortalityDisease StudyHealth sector changeHealth sector reformCoordinated multisectoral approachBurden of morbidityYLL ratesEstimates of mortalityDALY ratesHealth programmesVital registrationMultisectoral approachAll-causeHealth statusGlobal, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study
Tyrovolas S, Stergachis A, Krish V, Chang A, Skirbekk V, Dieleman J, Chatterji S, Abd-Allah F, Abdollahi M, Abedi A, Abolhassani H, Abosetugn A, Abreu L, Abrigo M, Abu Haimed A, Adabi M, Adebayo O, Adedeji I, Adekanmbi V, Adetokunboh O, Adham D, Advani S, Afarideh M, Agarwal G, Aghaali M, Aghamir S, Agrawal A, Ahmad S, Ahmad T, Ahmadi K, Ahmadi M, Ahmed M, Akinyemi R, Al-Aly Z, Alam K, Alanezi F, Alanzi T, Alcalde-Rabanal J, Alemu B, Al-Hajj S, Alhassan R, Ali S, Alicandro G, Alijanzadeh M, Alipour V, Aljunid S, Alla F, Almadi M, Almasi-Hashiani A, Almulhim A, Al-Raddadi R, Aminorroaya A, Amiri F, Amit A, Amugsi D, Anbesu E, Ancuceanu R, Anderlini D, Andrei T, Andrei C, Androudi S, Anjomshoa M, Ansari F, Ansari-Moghaddam A, Antonio C, Antony B, Anvari D, Anwer R, Arabloo J, Arab-Zozani M, Ärnlöv J, Asaad M, Asadi-Aliabadi M, Asadi-Pooya A, Atout M, Ausloos M, Ausloos F, Quintanilla B, Ayano G, Ayanore M, Aynalem Y, Azari S, Azene Z, Babaee E, Badiye A, Balachandran A, Banach M, Banerjee S, Banik P, Barker-Collo S, Basu S, Baune B, Bayati M, Baye B, Bedi N, Beghi E, Béjot Y, Bell M, Bensenor I, Bhagavathula A, Bhardwaj P, Bhattacharyya K, Bhattarai S, Bhutta Z, Bibi S, Bijani A, Bikbov B, Biondi A, Birihane B, Biswas A, Bjørge T, Bohlouli S, Bolla S, Boloor A, Boufous S, Braithwaite D, Brenner H, Briggs A, Briko N, Britton G, Nagaraja S, Busse R, Butt Z, dos Santos F, Cámera L, Car J, Cárdenas R, Carreras G, Carrero J, Carvalho F, Castaldelli-Maia J, Castañeda-Orjuela C, Castelpietra G, Castro F, Cerin E, Cevik M, Chandan J, Chang A, Charan J, Chattu V, Chaturvedi P, Chaturvedi S, Chavan P, Chen S, Cherbuin N, Chin K, Cho D, Chowdhury M, Chu D, Chung S, Chung M, Ciobanu L, Costa V, Cousin E, Criqui M, Cross M, Dahlawi S, Damiani G, Dandona L, Dandona R, Daneshpajouhnejad P, Das J, Gupta R, Dávila-Cervantes C, Davletov K, Deeba F, De Leo D, Denova-Gutiérrez E, Dervenis N, Desai R, Dharmaratne S, Dhungana G, Dianatinasab M, da Silva D, Diaz D, Dichgans M, Djalalinia S, Dokova K, Dorostkar F, Doshmangir L, Duncan B, Duraes A, Eagan A, Kalan M, Edvardsson D, Effiong A, Ehrlich J, Elgendy I, El-Jaafary S, Sayed I, Zaki M, Tantawi M, Eshrati B, Eskandari K, Eskandarieh S, Esmaeilnejad S, Etisso A, Faris P, Faro A, Farzadfar F, Fazlzadeh M, Feigin V, Fereshtehnejad S, Fernandes E, Ferrara P, Ferreira M, Filip I, Fischer F, Fisher J, Foigt N, Folayan M, Fomenkov A, Foroutan M, Franklin R, Freitas M, Gad M, Gallus S, Gamkrelidze A, Gebre A, Gebremeskel L, Ghaffarifar F, Ghafourifard M, Ghajarzadeh M, Gheshlagh R, Ghashghaee A, Ghith N, Gholamian A, Gill T, Gillum R, Giné-Vázquez I, Giussani G, Glagn M, Gnedovskaya E, Godinho M, Goharinezhad S, Gopalani S, Gorini G, Goulart A, Grivna M, Gugnani H, Guimarães R, Guo Y, Gupta R, Gutiérrez R, Hafiz A, Haj-Mirzaian A, Haj-Mirzaian A, Hamadeh R, Hamidi S, Hankey G, Haririan H, Haro J, Hasaballah A, Hashemian M, Hashi A, Hassan S, Hassan A, Hassanipour S, Hay S, Hayat K, Heidari-Soureshjani R, Hendrie D, Herteliu C, Ho H, Hoang C, Holla R, Hoogar P, Hossain N, Hosseini M, Hosseinzadeh M, Hostiuc M, Hostiuc S, Househ M, Hsairi M, Hu G, Humayun A, Hwang B, Iavicoli I, Ibitoye S, Ilesanmi O, Ilic I, Ilic M, Inbaraj L, Iqbal U, Irvani S, Islam, Iso H, Ivers R, Iwu C, Iwu C, Jaafari J, Jahani M, Jakovljevic M, Jalilian F, Janjani H, Janodia M, Javaheri T, Jenabi E, Jha R, Ji J, John O, Jonas J, Jozwiak J, Jürisson M, Kabir A, Kabir Z, Kalani R, Kalhor R, Kanchan T, Kapoor N, Matin B, Karch A, Kasa A, Kayode G, Karyani A, Khader Y, Khalid N, Khammarnia M, Khan M, Khan E, Khatab K, Khatib M, Khayamzadeh M, Khazaie H, Khoja A, Kim Y, Kim Y, Kimokoti R, Kisa S, Kisa A, Kivimäki M, Kneib C, Kochhar S, Koolivand A, Kopec J, Kotlo A, Koyanagi A, Krishan K, Defo B, Kumar G, Kumar N, Kumar M, Kurmi O, Kusuma D, Lacey B, Lal D, Lalloo R, Lallukka T, Lam J, Lami F, Landires I, Lansingh V, Larsson A, Lasrado S, Lauriola P, La Vecchia C, Leasher J, Lebedev G, Lee P, Lee S, Leigh J, Leonardi M, Levey A, Levi M, Li S, Linn S, Liu X, Lopez A, Lopukhov P, Lorkowski S, Lotufo P, Lozano R, Lugo A, Lunevicius R, Madadin M, Maddison R, Mahasha P, Mahmoudi M, Majeed A, Maleki S, Maleki A, Malekzadeh R, Malta D, Mamun A, Manafi N, Mansour-Ghanaei F, Mansouri B, Mansournia M, Martini S, Martins-Melo F, Masoumi S, Massano J, Maulik P, Mazidi M, McGrath J, McKee M, Mehndiratta M, Mehri F, Mejia-Rodriguez F, Mendoza W, Menezes R, Mensah G, Mereke A, Meretoja T, Meretoja A, Mestrovic T, Miazgowski T, Michalek I, Miller T, Mills E, Mirica A, Mirrakhimov E, Mirzaei H, Mirzaei M, Mirzaei-Alavijeh M, Mitchell P, Moazen B, Moghadaszadeh M, Mohamadi E, Mohammad Y, Mohammad D, Mohammadi S, Mohammadian-Hafshejani A, Mohammed S, Mokdad A, Molassiotis A, Momen N, Mondello S, Moradi M, Moradi-Lakeh M, Moradpour F, Moradzadeh R, Moraga P, Morawska L, Mori R, Mousavi S, Khaneghah A, Mueller U, Mukhopadhyay S, Muriithi M, Naderi M, Nagarajan A, Naghshtabrizi B, Naimzada M, Najafi F, Nansseu J, Ndejjo R, Negoi 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Rumisha S, Saadatagah S, Sabour S, Sachdev P, Sadeghi M, Sadeghi E, Moghaddam S, Sagar R, Sahraian M, Sajadi S, Salam N, Salem M, Salimzadeh H, Salman O, Samy A, Sanabria J, Riera L, Santos I, Santric-Milicevic M, Saraswathy S, Sarveazad A, Sathian B, Sathish T, Sattin D, Schiavolin S, Schmidt M, Schutte A, Schwebel D, Schwendicke F, Senthilkumaran S, Sepanlou S, Sha F, Shafaat O, Shahabi S, Shaheen A, Shaikh M, Shakhnazarova M, Shams-Beyranvand M, Shamsi M, Shamsizadeh M, Sharafi K, Shetty B, Shibuya K, Shiferaw W, Shigematsu M, Shin J, Shiri R, Shirkoohi R, Shuval K, Sigfusdottir I, Sigurvinsdottir R, Silva J, Simonetti B, Singh J, Singh P, Singh A, Sinha D, Skou S, Skryabin V, Smith E, Sobhiyeh M, Soheili A, Soltani S, Soriano J, Soyiri I, Spurlock E, Sreeramareddy C, Stein D, Stockfelt L, Stokes M, Stranges S, Stubbs J, Sudaryanto A, Sufiyan M, Suleria H, Abdulkader R, Sulo G, Tabarés-Seisdedos R, Tabuchi T, Taddele B, Taherkhani A, Tajdini M, Tareque I, Tefera Y, Temsah M, Tessema Z, Thankappan K, Thapar R, Thrift A, Titova M, Tohidinik H, Tonelli M, Touvier M, Tovani-Palone M, Tran B, Travillian R, Tsai A, Tsatsakis A, Uddin R, Ullah S, Umeokonkwo C, Unnikrishnan B, Vacante M, Valdez P, van Donkelaar A, Varughese S, Vasankari T, Vasseghian Y, Veisani Y, Venketasubramanian N, Violante F, Vlassov V, Waheed Y, Wang Y, Wang F, Wang Y, Wei J, Weintraub R, Weiss J, Westerman R, Wiangkham T, Wolfe C, Wu A, Jabbari S, Yamagishi K, Yano Y, Yaya S, Yazdi-Feyzabadi V, Yeshitila Y, Yimmer M, Yip P, Yonemoto N, Yoon S, Younis M, Yousefi Z, Yousefinezhadi T, Yu C, Yu Y, Yusefzadeh H, Zaidi S, Bin Zaman S, Zamanian M, Zarafshan H, Zastrozhin M, Zhang Z, Zhang J, Zhang Y, Zhao X, Zhu C, Kotsakis G, Kassebaum N. Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study. The BMJ 2022, 376: e068208. PMID: 35273014, PMCID: PMC9316948, DOI: 10.1136/bmj-2021-068208.Peer-Reviewed Original ResearchConceptsHealthy life expectancyBurden of diseaseHealthcare accessDisability burdenLife expectancyOlder adultsRisk factorsGlobal burdenPopulation of older adultsGlobal Burden of DiseaseNational burden of diseaseNon-communicable diseasesDisability adjusted life yearsRisk Factors StudyYears of lifeHigh-income countriesAdjusted life yearsProportion of yearsHigher life expectancyExposure risk factorsEnhance public healthSymptoms of painAge 70Hearing lossDisability trends
2021
Global, regional, and national burden and quality of care index of endocarditis: the global burden of disease study 1990–2019
Momtazmanesh S, Moghaddam S, Rad E, Azadnajafabad S, Ebrahimi N, Mohammadi E, Rouhifard M, Rezaei N, Masinaei M, Rezaei N, Keykhaei M, Aminorroaya A, Ghamari A, Larijani B, Farzadfar F. Global, regional, and national burden and quality of care index of endocarditis: the global burden of disease study 1990–2019. European Journal Of Preventive Cardiology 2021, 29: 1287-1297. PMID: 34897404, DOI: 10.1093/eurjpc/zwab211.Peer-Reviewed Original ResearchConceptsGlobal Burden of Disease StudyBurden of Disease StudyAssess quality of careGlobal burdenQuality of careDisability-adjusted life yearsDisease StudyHigh-income North AmericaAntibiotic prophylaxis guidelinesSocio-demographic indexAge groupsYears of lifeHigh-income countriesOptimal patient outcomesIndex of MortalityLow-income countriesNational burdenProphylaxis guidelinesAssess qualitySignificant morbidityPrompt treatmentIncidence rateEndocarditisLife yearsTimely diagnosisGlobal, regional, and national mortality among young people aged 10–24 years, 1950–2019: a systematic analysis for the Global Burden of Disease Study 2019
Collaborators G, Ward J, Azzopardi P, Francis K, Santelli J, Skirbekk V, Sawyer S, Kassebaum N, Mokdad A, Hay S, Abd-Allah F, Abdoli A, Abdollahi M, Abedi A, Abolhassani H, Abreu L, Abrigo M, Abu-Gharbieh E, Abushouk A, Adebayo O, Adekanmbi V, Adham D, Advani S, Afshari K, Agrawal A, Ahmad T, Ahmadi K, Ahmed A, Aji B, Akombi-Inyang B, Alahdab F, Al-Aly Z, Alam K, Alanezi F, Alanzi T, Alcalde-Rabanal J, Alemu B, Al-Hajj S, Alhassan R, Ali S, Alicandro G, Alijanzadeh M, Aljunid S, Almasi-Hashiani A, Almasri N, Al-Mekhlafi H, Alonso J, Al-Raddadi R, Altirkawi K, Alvis-Guzman N, Amare A, Amini S, Aminorroaya A, Amit A, Amugsi D, Ancuceanu R, Anderlini D, Andrei C, Androudi S, Ansari F, Ansari I, Antonio C, Anvari D, Anwer R, Appiah S, Arabloo J, Arab-Zozani M, Ärnlöv J, Asaad M, Asadi-Aliabadi M, Asadi-Pooya A, Atout M, Ausloos M, Avenyo E, Avila-Burgos L, Quintanilla B, Ayano G, Aynalem Y, Azari S, Azene Z, Bakhshaei M, Bakkannavar S, Banach M, Banik P, Barboza M, Barker-Collo S, Bärnighausen T, Basu S, Baune B, Bayati M, Bedi N, Beghi E, Bekuma T, Bell A, Bell M, Benjet C, Bensenor I, Berhe A, Berhe K, Berman A, Bhagavathula A, Bhardwaj N, Bhardwaj P, Bhattacharyya K, Bhattarai S, Bhutta Z, Bijani A, Bikbov B, Biondi A, Birhanu T, Biswas R, Bohlouli S, Bolla S, Boloor A, Borschmann R, Boufous S, Bragazzi N, Braithwaite D, Breitborde N, Brenner H, Britton G, Burns R, Nagaraja S, Butt Z, dos Santos F, Cámera L, Campos-Nonato I, Rincon J, Cárdenas R, Carreras G, Carrero J, Carvalho F, Castaldelli-Maia J, Castañeda-Orjuela C, Castelpietra G, Catalá-López F, Cerin E, Chandan J, Chang H, Chang J, Charan J, Chattu V, Chaturvedi S, Choi J, Chowdhury M, Christopher D, Chu D, Chung M, Chung S, Cicuttini F, Constantin T, Costa V, Dahlawi S, Dai H, Dai X, Damiani G, Dandona L, Dandona R, Daneshpajouhnejad P, Darwesh A, Dávila-Cervantes C, Davletov K, De la Hoz F, De Leo D, Dervenis N, Desai R, Desalew A, Deuba K, Dharmaratne S, Dhungana G, Dianatinasab M, da Silva D, Diaz D, Didarloo A, Djalalinia S, Dorostkar F, Doshi C, Doshmangir L, Doyle K, Duraes A, Kalan M, Ebtehaj S, Edvardsson D, Tantawi M, Elgendy I, El-Jaafary S, Elsharkawy A, Eshrati B, Eskandarieh S, Esmaeilnejad S, Esmaeilzadeh F, Esteghamati S, Faro A, Farzadfar F, Fattahi N, Feigin V, Ferede T, Fereshtehnejad S, Fernandes E, Ferrara P, Filip I, Fischer F, Fisher J, Foigt N, Folayan M, Fomenkov A, Foroutan M, Fukumoto T, Gad M, Gaidhane A, Gallus S, Gebre T, Gebremedhin K, Gebremeskel G, Gebremeskel L, Gebreslassie A, Gesesew H, Ghadiri K, Ghafourifard M, Ghamari F, Ghashghaee A, Gilani S, Gnedovskaya E, Godinho M, Golechha M, Goli S, Gona P, Gopalani S, Gorini G, Grivna M, Gubari M, Gugnani H, Guimarães R, Guo Y, Gupta R, Haagsma J, Hafezi-Nejad N, Haile T, Haj-Mirzaian A, Haj-Mirzaian A, Hall B, Hamadeh R, Abdullah K, Hamidi S, Handiso D, Hanif A, Hankey G, Haririan H, Haro J, Hasaballah A, Hashi A, Hassan A, Hassanipour S, Hassankhani H, Hayat K, Heidari-Soureshjani R, Herteliu C, Heydarpour F, Ho H, Hole M, Holla R, Hoogar P, Hosseini M, Hosseinzadeh M, Hostiuc M, Hostiuc S, Househ M, Hsairi M, Huda T, Humayun A, Hussain R, Hwang B, Iavicoli I, Ibitoye S, Ilesanmi O, Ilic I, Ilic M, Inbaraj L, Intarut N, Iqbal U, Irvani S, Islam M, Islam M, Iso H, Ivers R, Jahani M, Jakovljevic M, Jalali A, Janodia M, Javaheri T, Jeemon P, Jenabi E, Jha R, Jha V, Ji J, Jonas J, Jones K, Joukar F, Jozwiak J, Juliusson P, Jürisson M, Kabir A, Kabir Z, Kalankesh L, Kalhor R, Kamyari N, Kanchan T, Karch A, Karimi S, Kaur S, Kayode G, Keiyoro P, Khalid N, Khammarnia M, Khan M, Khan N, Khatab K, Khater M, Khatib M, Khayamzadeh M, Khazaie H, Khoja A, Kieling C, Kim Y, Kim Y, Kimokoti R, Kisa A, Kisa S, Kivimäki M, Koolivand A, Kosen S, Koyanagi A, Krishan K, Kugbey N, Kumar G, Kumar M, Kumar N, Kurmi O, Kusuma D, La Vecchia C, Lacey B, Lal D, Lalloo R, Lan Q, Landires I, Lansingh V, Larsson A, Lasrado S, Lassi Z, Lauriola P, Lee P, Lee S, Leigh J, Leonardi M, Leung J, Levi M, Lewycka S, Li B, Li M, Li S, Lim L, Lim S, Liu X, Lorkowski S, Lotufo P, Lunevicius R, Maddison R, Mahasha P, Mahdavi M, Mahmoudi M, Majeed A, Maleki A, Malekzadeh R, Malta D, Mamun A, Mansouri B, Mansournia M, Martinez G, Martinez-Raga J, Martins-Melo F, Mason-Jones A, Masoumi S, Mathur M, Maulik P, McGrath J, Mehndiratta M, Mehri F, Memiah P, Mendoza W, Menezes R, Mengesha E, Meretoja A, Meretoja T, Mestrovic T, Miazgowski B, Miazgowski T, Michalek I, Miller T, Mini G, Mirica A, Mirrakhimov E, Mirzaei H, Mirzaei M, Moazen B, Mohammad D, Mohammadi S, Mohammadian-Hafshejani A, Mohammadifard N, Mohammadpourhodki R, Mohammed S, Monasta L, Moradi G, Moradi-Lakeh M, Moradzadeh R, Moraga P, Morrison S, Mosapour A, Khaneghah A, Mueller U, Muriithi M, Murray C, Muthupandian S, Naderi M, Nagarajan A, Naghavi M, Naimzada M, Nangia V, Nayak V, Nazari J, Ndejjo R, Negoi I, Negoi R, Netsere H, Nguefack-Tsague G, Nguyen D, Nguyen H, Nie J, Ningrum D, Nnaji C, Nomura S, Noubiap J, Nowak C, Nuñez-Samudio V, Ogbo F, Oghenetega O, Oh I, Oladnabi M, Olagunju A, Olusanya B, Olusanya J, Bali A, Omer M, Onwujekwe O, Ortiz A, Otoiu A, Otstavnov N, Otstavnov S, Øverland S, Owolabi M, Mahesh P, Padubidri J, Pakshir K, Palladino R, Pana A, Panda-Jonas S, Pandey A, Panelo C, Park E, Patten S, Peden A, Pepito V, Peprah E, Pereira J, Pesudovs K, Pham H, Phillips M, Piradov M, Pirsaheb M, Postma M, Pottoo F, Pourjafar H, Pourshams A, Prada S, Pupillo E, Syed Z, Rabiee M, Rabiee N, Radfar A, Rafiee A, Raggi A, Rahim F, Rahimi-Movaghar V, Rahman M, Rahman M, Ramezanzadeh K, Ranabhat C, Rao S, Rashedi V, Rastogi P, Rathi P, Rawaf D, Rawaf S, Rawal L, Rawassizadeh R, Renzaho A, Rezaei N, Rezaei N, Rezai M, Riahi S, Rickard J, Roever L, Ronfani L, Roth G, Rubagotti E, Rumisha S, Rwegerera G, Sabour S, Sachdev P, Saddik B, Sadeghi E, Moghaddam S, Sagar R, Sahebkar A, Sahraian M, Sajadi S, Salem M, Salimzadeh H, Samy A, Sanabria J, Santric-Milicevic M, Saraswathy S, Sarrafzadegan N, Sarveazad A, Sathish T, Sattin D, Saxena D, Saxena S, Schiavolin S, Schwebel D, Schwendicke F, Senthilkumaran S, Sepanlou S, Sha F, Shafaat O, Shahabi S, Shaheen A, Shaikh M, Shakiba S, Shamsi M, Shannawaz M, Sharafi K, Sheikh A, Sheikhbahaei S, Shetty B, Shi P, Shigematsu M, Shin J, Shiri R, Shuval K, Siabani S, Sigfusdottir I, Sigurvinsdottir R, Silva D, Silva J, Simonetti B, Singh J, Singh V, Sinke A, Skryabin V, Slater H, Smith E, Sobhiyeh M, Sobngwi E, Soheili A, Somefun O, Sorrie M, Soyiri I, Sreeramareddy C, Stein D, Stokes M, Sudaryanto A, Sultan I, Tabarés-Seisdedos R, Tabuchi T, Tadakamadla S, Taherkhani A, Tamiru A, Tareque I, Thankappan K, Thapar R, Thomas N, Titova M, Tonelli M, Tovani-Palone M, Tran B, Travillian R, Tsai A, Tsatsakis A, Car L, Uddin R, Unim B, Unnikrishnan B, Upadhyay E, Vacante M, Tahbaz S, Valdez P, Varughese S, Vasankari T, Venketasubramanian N, Villeneuve P, Violante F, Vlassov V, Vos T, Vu G, Waheed Y, Wamai R, Wang Y, Wang Y, Wang Y, Westerman R, Wickramasinghe N, Wu A, Wu C, Jabbari S, Yamagishi K, Yano Y, Yaya S, Yazdi-Feyzabadi V, Yeshitila Y, Yip P, Yonemoto N, Yoon S, Younis M, Yousefinezhadi T, Yu C, Yu Y, Yuce D, Zaidi S, Bin Zaman S, Zamani M, Zamanian M, Zarafshan H, Zarei A, Zastrozhin M, Zhang Y, Zhang Z, Zhao X, Zhu C, Patton G, Viner R. Global, regional, and national mortality among young people aged 10–24 years, 1950–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet 2021, 398: 1593-1618. PMID: 34755628, PMCID: PMC8576274, DOI: 10.1016/s0140-6736(21)01546-4.Peer-Reviewed Original ResearchConceptsSocio-demographic indexAdolescent mortalityMaternal causesAge groupsYoung peopleGlobal burdenGlobal Burden of Disease StudyAged 0Burden of Disease StudyGlobal Burden of DiseaseMortality rateDeterminants of adolescent healthImprove health outcomesAnnual percentage decreaseNon-communicable diseasesGBD super-regionsPeople aged 0Risk Factors StudyAdolescent deathsBurden of diseaseChildren aged 0Years of lifeIncome per capitaAged 1Social determinantsPrevalence and trends of coronary artery disease risk factors and their effect on age of diagnosis in patients with established coronary artery disease: Tehran Heart Center (2005–2015)
Hosseini K, Mortazavi S, Sadeghian S, Ayati A, Nalini M, Aminorroaya A, Tavolinejad H, Salarifar M, Pourhosseini H, Aein A, Jalali A, Bozorgi A, Mehrani M, Kamangar F. Prevalence and trends of coronary artery disease risk factors and their effect on age of diagnosis in patients with established coronary artery disease: Tehran Heart Center (2005–2015). BMC Cardiovascular Disorders 2021, 21: 477. PMID: 34607557, PMCID: PMC8491372, DOI: 10.1186/s12872-021-02293-y.Peer-Reviewed Original ResearchConceptsCAD risk factorsRisk factorsTehran Heart CenterOpium useDisease risk factorsEffect of opium useCoronary artery disease risk factorsArtery disease risk factorsMiddle-income countriesYears earlier ageHigher risk of CADHeart CenterCAD diagnosisCross-sectional studyPublic health challengeArtery diseaseAssociated with higher riskBody-mass indexRisk of CADConventional CAD risk factorsAge of CAD onsetLipid profile componentsTraditional risk factorsHypertension prevalenceAge of diagnosis