2020
Evolution of Embryo Implantation Was Enabled by the Origin of Decidual Stromal Cells in Eutherian Mammals
Chavan AR, Griffith OW, Stadtmauer D, Maziarz J, Pavlicev M, Fishman R, Koren L, Romero R, Wagner GP. Evolution of Embryo Implantation Was Enabled by the Origin of Decidual Stromal Cells in Eutherian Mammals. Molecular Biology And Evolution 2020, 38: 1060-1074. PMID: 33185661, PMCID: PMC7947829, DOI: 10.1093/molbev/msaa274.Peer-Reviewed Original ResearchConceptsEutherian mammalsEutherian lineagesDecidual stromal cellsNovel cell typesStromal cellsInflammatory responseStem lineageEutherian pregnancyCommon ancestorEvolutionary mechanismsExtended gestationMost marsupialsEmbryo attachmentEmbryo implantationMarsupialsLineagesCell typesMammalsMechanistic understandingEutheriansHelper T cellsFetal-maternal interfaceMammalian pregnancyMaternal tissuesNeutrophil recruitment
2018
The mammalian decidual cell evolved from a cellular stress response
Erkenbrack EM, Maziarz JD, Griffith OW, Liang C, Chavan AR, Nnamani MC, Wagner GP. The mammalian decidual cell evolved from a cellular stress response. PLOS Biology 2018, 16: e2005594. PMID: 30142145, PMCID: PMC6108454, DOI: 10.1371/journal.pbio.2005594.Peer-Reviewed Original ResearchConceptsCellular stress responseNovel cell typesStress responseEndometrial stromal fibroblastsCell typesCell type diversityDecidual stromal cellsCore regulatory genesOxidative stress responseDecidual cell typesEvolutionary noveltyPrecursor cell typesEffector genesRegulatory genesEutherian mammalsTranscription factorsOpossum Monodelphis domesticaOrganismal structureType diversityMolecular mechanismsAnimal speciesMonodelphis domesticaGenesStromal cellsSpecies
2017
The inflammation paradox in the evolution of mammalian pregnancy: turning a foe into a friend
Chavan AR, Griffith OW, Wagner GP. The inflammation paradox in the evolution of mammalian pregnancy: turning a foe into a friend. Current Opinion In Genetics & Development 2017, 47: 24-32. PMID: 28850905, DOI: 10.1016/j.gde.2017.08.004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological EvolutionBlastocystEmbryo ImplantationFemaleHumansImmune SystemInflammationMammalsMaternal-Fetal RelationsPregnancyConceptsAdaptive immune systemMammalian pregnancyOutcome of pregnancySemi-allogenic fetusInfluence of inflammationContinuation of pregnancyImmunological paradoxAcute inflammationMaternal healthWorse inflammationEndometrial inflammationVascular permeabilityEmbryo implantationInflammationImmune systemPregnancyMaternal reactionsFetusesImplantationMatrix reorganizationEmbryo implantation evolved from an ancestral inflammatory attachment reaction
Griffith OW, Chavan AR, Protopapas S, Maziarz J, Romero R, Wagner GP. Embryo implantation evolved from an ancestral inflammatory attachment reaction. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e6566-e6575. PMID: 28747528, PMCID: PMC5559003, DOI: 10.1073/pnas.1701129114.Peer-Reviewed Original ResearchConceptsTerm pregnancyMaterno-fetal interfaceEGF-like growth factorInflammatory responseImmune responseEmbryo implantationPregnancyGrowth factorMucin 1Molecular changesImplantationKey markersMiceParturitionExhibit expressionMorphological changesHumansOpossumEutherian mammalsUterusImmunohistochemistryTranscriptomic analysisPlacentaImplantation reactionLocalization profiles
2016
What was the ancestral function of decidual stromal cells? A model for the evolution of eutherian pregnancy
Chavan AR, Bhullar BA, Wagner GP. What was the ancestral function of decidual stromal cells? A model for the evolution of eutherian pregnancy. Placenta 2016, 40: 40-51. PMID: 27016782, DOI: 10.1016/j.placenta.2016.02.012.Peer-Reviewed Original ResearchConceptsEutherian mammalsDecidual stromal cellsAncestral functionEutherian cladesMajor lineagesStem lineageEutherian pregnancyStromal cellsEutherian speciesStem eutheriansExtended gestationMammalsEutheriansLineagesMaintenance of pregnancyCellsInvasive placentationLaurasiatheriaCladeEuarchontogliresAfrotheriaFetal-maternal interfaceXenarthraDecidual cellsSpecies