2009
MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice
Roth RJ, Le AM, Zhang L, Kahn M, Samuel VT, Shulman GI, Bennett AM. MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice. Journal Of Clinical Investigation 2009, 119: 3817-3829. PMID: 19920356, PMCID: PMC2786792, DOI: 10.1172/jci39054.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceDietary FatsDNA PrimersDual Specificity Phosphatase 1Energy MetabolismMAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutModels, BiologicalMuscle Fibers, Slow-TwitchObesityP38 Mitogen-Activated Protein KinasesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaRNA, MessengerTrans-ActivatorsTranscription FactorsUp-Regulation
1996
Multiple Requirements for SHPTP2 in Epidermal Growth Factor-Mediated Cell Cycle Progression
Bennett A, Hausdorff S, O’Reilly A, Freeman R, Neel B. Multiple Requirements for SHPTP2 in Epidermal Growth Factor-Mediated Cell Cycle Progression. Molecular And Cellular Biology 1996, 16: 1189-1202. PMID: 8622663, PMCID: PMC231101, DOI: 10.1128/mcb.16.3.1189.Peer-Reviewed Original ResearchConceptsElk-1 transactivationS-phase entryMitogen-activated proteinMAP kinase activationGrowth factorKinase activationFusion proteinPlatelet-derived growth factorGlutathione S-transferase fusion proteinEpidermal growth factor stimulationS-transferase fusion proteinProtein tyrosine phosphatase activityTyrosyl phosphorylation sitesGrowth factor stimulationSignal transduction pathwaysSerum-induced S-phase entryGrowth factor signalingImmediate early responseNIH 3T3 cellsCell cycle progressionEpidermal growth factorSH2 domainPhosphorylation sitesEGF stimulationTransduction pathways
1995
Different Signaling Roles of SHPTP2 in Insulin-induced GLUT1 Expression and GLUT4 Translocation ∗
Hausdorff S, Bennett A, Neel B, Birnbaum M. Different Signaling Roles of SHPTP2 in Insulin-induced GLUT1 Expression and GLUT4 Translocation ∗. Journal Of Biological Chemistry 1995, 270: 12965-12968. PMID: 7768884, DOI: 10.1074/jbc.270.22.12965.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsBase SequenceBiological TransportDNA PrimersGlucose Transporter Type 1Glucose Transporter Type 4InsulinIntracellular Signaling Peptides and ProteinsMiceMicroinjectionsMolecular Sequence DataMonosaccharide Transport ProteinsMuscle ProteinsProtein Tyrosine Phosphatase, Non-Receptor Type 1Protein Tyrosine Phosphatase, Non-Receptor Type 11Protein Tyrosine Phosphatase, Non-Receptor Type 6Protein Tyrosine PhosphatasesRNA, MessengerSignal TransductionConceptsGLUT4 translocationNon-transmembrane protein tyrosine phosphataseSrc homology 2 domainGlutathione S-transferase fusion proteinS-transferase fusion proteinC-terminal SH2 domainCell surface GLUT1Insulin receptor substrate-1Cell surfaceProtein tyrosine phosphataseInsulin-stimulated mitogenesisTranslocation of GLUT4Insulin-stimulated expressionReceptor substrate-1Insulin-induced DNA synthesisInsulin-stimulated increaseNIH 3T3 fibroblastsSH2 domainSHPTP2Signaling roleSubstrate-1Fusion proteinInsulin stimulationMetabolic pathwaysIndependent pathways
1994
Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.
Bennett A, Tang T, Sugimoto S, Walsh C, Neel B. Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 7335-7339. PMID: 8041791, PMCID: PMC44394, DOI: 10.1073/pnas.91.15.7335.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsBase SequenceBinding SitesCell LineDNAGenes, rasHumansIntracellular Signaling Peptides and ProteinsMiceMice, Inbred BALB CMolecular Sequence DataPhosphorylationProtein Tyrosine Phosphatase, Non-Receptor Type 11Protein Tyrosine Phosphatase, Non-Receptor Type 6Protein Tyrosine PhosphatasesReceptors, Platelet-Derived Growth FactorSH2 Domain-Containing Protein Tyrosine PhosphatasesSignal TransductionConceptsPlatelet-derived growth factor receptor betaGrowth factor receptor betaPDGF stimulationPositive signalingReceptor tyrosine kinasesSH2 domainRas activationGrowth factor receptorReceptor betaTyrosine phosphorylationSHPTP2Gene productsTyrosine kinaseGrb2Vivo sitesFactor receptorPhosphorylationSignalingPositive signalsSOS1RAHomologuesKinaseSite displayBeta