2020
Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines
Yi JS, Perla S, Enyenihi L, Bennett AM. Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines. JCI Insight 2020, 5 PMID: 32584792, PMCID: PMC7455087, DOI: 10.1172/jci.insight.137753.Peer-Reviewed Original ResearchConceptsProtein tyrosine phosphataseTyrosyl phosphorylationNSML micePhosphorylation-defective mutantPTPN11 mutationsS6 kinase activityPZR tyrosyl phosphorylationTyrosine phosphataseS6 kinasePathophysiological signalingKinase activityShp2 interactionMutant fibroblastsSHP2Transmembrane glycoproteinMultiple lentiginesNoonan syndromeCraniofacial defectsPTPN11 geneHeart lysatesPhosphorylationSHP2 bindingMutationsNF-κB pathwayProtein zero
2013
Mitogen-Activated Protein Kinase Phosphatases in Metabolism
Lawan A, Bennett A. Mitogen-Activated Protein Kinase Phosphatases in Metabolism. 2013, 221-238. DOI: 10.1007/978-1-4614-7855-3_12.Peer-Reviewed Original ResearchMitogen-activated protein kinaseMetabolic homeostasisProtein kinaseTissue-specific mannerFamily of enzymesDirect dephosphorylationPathophysiological signalingMAPK activityMAPK inactivationMetabolic signalingImportant playersMKPHomeostasisKinaseCritical roleSignalingBody of evidenceMetabolismDephosphorylationComplex networksComparable levelsEnzymeMitogenPathwayRegulation