IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM
Catanzaro JR, Strauss JD, Bielecka A, Porto AF, Lobo FM, Urban A, Schofield WB, Palm NW. IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM. Scientific Reports 2019, 9: 13574. PMID: 31537840, PMCID: PMC6753154, DOI: 10.1038/s41598-019-49923-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultBacteriaCase-Control StudiesDNA, RibosomalDysbiosisFemaleHumansImmunoglobulin A, SecretoryImmunoglobulin MMalePhylogenyRNA, Ribosomal, 16SSequence Analysis, DNAConceptsGut microbiota compositionOverall microbial diversityHost-microbiota symbiosisSpecific microbial taxaGut microbial communityHuman gut microbiota compositionNon-redundant roleRRNA gene sequencingMicrobiota compositionMicrobial taxaMicrobial communitiesMicrobial diversityHealthy controlsSecretory IgAMucosal secretionsIgA-deficient humansBacterial cellsRelative abundanceAltered gut microbiota compositionGene sequencingDominant antibody isotypeDefined subsetsGut microbiota dysbiosisMicrobiotaMicrobiota dysbiosis