2018
Assessment of Community Pediatric Providers’ Approach to a Child With Celiac Disease and Available Serological Testing Associated With a Large Tertiary Care Center
Alrabadi LS, Porto AF. Assessment of Community Pediatric Providers’ Approach to a Child With Celiac Disease and Available Serological Testing Associated With a Large Tertiary Care Center. Clinical Pediatrics 2018, 57: 1199-1203. PMID: 29667919, DOI: 10.1177/0009922818769453.Peer-Reviewed Original ResearchConceptsLarge tertiary care centerTertiary care centerEvidence-practice gapCeliac disease testingFalse-positive testsGastroenterology consultsGuideline recommendationsCeliac diseaseCare centerPatient concernsPediatric providersProvider practicesPositive testDisease testingAdditional testingDiet changeConsultsDisease
2016
Tissue Transglutaminase Levels Are Not Sufficient to Diagnose Celiac Disease in North American Practices Without Intestinal Biopsies
Elitsur Y, Sigman T, Watkins R, Porto AF, Leonard Puppa EL, Foglio EJ, Preston DL. Tissue Transglutaminase Levels Are Not Sufficient to Diagnose Celiac Disease in North American Practices Without Intestinal Biopsies. Digestive Diseases And Sciences 2016, 62: 175-179. PMID: 27778203, DOI: 10.1007/s10620-016-4354-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAutoantibodiesBiopsyCeliac DiseaseChildChild, PreschoolDuodenumFemaleGTP-Binding ProteinsHumansImmunoglobulin AInfantIntestine, SmallMaleNorth AmericaPredictive Value of TestsProtein Glutamine gamma Glutamyltransferase 2Retrospective StudiesSensitivity and SpecificityTransglutaminasesConceptsCeliac diseasePositive predictive valuePredictive valueIntestinal biopsiesIntestinal histologyTissue transglutaminase levelsRoutine clinical practiceNegative predictive valueNorth American childrenCeliac childrenPositive serologySymptomatic childrenAmerican guidelinesClinical practiceDifferent clinicsHigh titersDiseaseBiopsyTransglutaminase levelsTitersTissue transglutaminaseChildrenSerologyHistologyPresent study
2013
Cholesteryl Ester Storage Disease
Zhang B, Porto AF. Cholesteryl Ester Storage Disease. Journal Of Pediatric Gastroenterology And Nutrition 2013, 56: 682-685. PMID: 23403440, DOI: 10.1097/mpg.0b013e31828b36ac.Peer-Reviewed Original ResearchConceptsCholesteryl ester storage diseaseEarly diagnosisLysosomal acid lipaseStorage diseasePertinent laboratory testsLIPA gene mutationsEnzyme replacement therapyAcid lipaseTwo-thirdsEnglish-language publicationsGastrointestinal symptomsFatty liverSerum transaminasesCommon symptomsPediatric casesReplacement therapyCase reportLiver fibrosisFirst symptomsPubMed searchNew treatmentsSymptomsPatientsWolman diseaseGene mutations
2012
Management of chronic hepatitis C infection in children
Porto AF, Tormey L, Lim JK. Management of chronic hepatitis C infection in children. Current Opinion In Pediatrics 2012, 24: 113-120. PMID: 22157364, DOI: 10.1097/mop.0b013e32834eb73f.Peer-Reviewed Original ResearchConceptsChronic hepatitis C infectionHepatitis C infectionC infectionPeginterferon αAntiviral therapyLiver fibrosisGenotype 1Global public health burdenDevelopment of cirrhosisSustained virologic responseIndolent clinical courseLarge prospective studiesProgressive liver fibrosisPublic health burdenImportant clinical implicationsMajority of childrenAreas of controversyVirologic responseViral eradicationCombination regimensInfected childrenClinical courseProspective studyTreatment courseEarly treatment