Tissue Transglutaminase Levels Are Not Sufficient to Diagnose Celiac Disease in North American Practices Without Intestinal Biopsies
Elitsur Y, Sigman T, Watkins R, Porto AF, Leonard Puppa EL, Foglio EJ, Preston DL. Tissue Transglutaminase Levels Are Not Sufficient to Diagnose Celiac Disease in North American Practices Without Intestinal Biopsies. Digestive Diseases And Sciences 2016, 62: 175-179. PMID: 27778203, DOI: 10.1007/s10620-016-4354-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAutoantibodiesBiopsyCeliac DiseaseChildChild, PreschoolDuodenumFemaleGTP-Binding ProteinsHumansImmunoglobulin AInfantIntestine, SmallMaleNorth AmericaPredictive Value of TestsProtein Glutamine gamma Glutamyltransferase 2Retrospective StudiesSensitivity and SpecificityTransglutaminasesConceptsCeliac diseasePositive predictive valuePredictive valueIntestinal biopsiesIntestinal histologyTissue transglutaminase levelsRoutine clinical practiceNegative predictive valueNorth American childrenCeliac childrenPositive serologySymptomatic childrenAmerican guidelinesClinical practiceDifferent clinicsHigh titersDiseaseBiopsyTransglutaminase levelsTitersTissue transglutaminaseChildrenSerologyHistologyPresent study