2022
Legionella pneumophila and Staphylococcus aureus co-infections in a patient with SARS-CoV-2
Sanchez A, Elliott EI, Wang P, Spichler-Moffarah A. Legionella pneumophila and Staphylococcus aureus co-infections in a patient with SARS-CoV-2. BMJ Case Reports 2022, 15: e248536. PMID: 35232746, PMCID: PMC8889248, DOI: 10.1136/bcr-2021-248536.Peer-Reviewed Original ResearchConceptsCOVID-19 therapySARS-CoV-2Positive SARS-CoV-2 testSARS-CoV-2 testAcute febrile illnessCommunity-acquired pneumoniaSevere COVID-19Patient's successful recoveryCOVID-19COVID-19 managementSecond bacterial infectionMRSA pneumoniaFebrile illnessRespiratory symptomsInitial presentationHigh suspicionLobar pneumoniaWorse outcomesPositive testPatientsBacterial infectionsPneumoniaSuccessful recoveryLegionnaires' diseaseSerogroup 1
2020
Mycobacterium marinum: nodular hand lesions after a fishing expedition
Tuan J, Spichler-Moffarah A, Ogbuagu O. Mycobacterium marinum: nodular hand lesions after a fishing expedition. BMJ Case Reports 2020, 13: e238835. PMID: 33318281, PMCID: PMC7737068, DOI: 10.1136/bcr-2020-238835.Peer-Reviewed Case Reports and Technical NotesConceptsSoft tissue infectionsDeep space infectionsTissue infectionsSpace infectionAcid-fast bacilliTreatment of skinNon-tuberculous mycobacteriaTerms of treatmentDisseminated diseaseOptimal regimenHand lesionsMedical managementExtremity lesionsCombination therapyInfectionLesionsAddition of rifampicinFurther dataSkinTreatmentMycobacteriaOsteomyelitisRegimenPatientsSurgery
2007
Reversal of renal tubule transporter downregulation during severe leptospirosis with antimicrobial therapy.
Spichler A, Ko AI, Silva EF, De Brito T, Silva AM, Athanazio D, Silva C, Seguro A. Reversal of renal tubule transporter downregulation during severe leptospirosis with antimicrobial therapy. American Journal Of Tropical Medicine And Hygiene 2007, 77: 1111-9. PMID: 18165532, DOI: 10.4269/ajtmh.2007.77.1111.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAmpicillinAnimalsAnti-Bacterial AgentsAntigens, BacterialCricetinaeDown-RegulationFemaleFree Radical ScavengersGene Expression ProfilingGene Expression RegulationKidneyLiverMesocricetusSodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersSodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 1ThiobarbituratesWeil DiseaseConceptsSevere leptospirosisAntimicrobial therapyN-acetylcysteineSerum thiobarbituric acidEvidence of benefitThick ascending limbNKCC2 transportersRenal involvementRenal expressionTubular dysfunctionAntioxidant therapyInfected hamstersTubular defectsNAC effectAscending limbAmpicillin treatmentRenal transportersTherapyTarget tissuesLeptospiral antigensAMP treatmentType 3Reduced levelsTransporter downregulationNormal expression