The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo
Odenwald MA, Choi W, Kuo WT, Singh G, Sailer A, Wang Y, Shen L, Fanning AS, Turner JR. The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo. Journal Of Biological Chemistry 2018, 293: 17317-17335. PMID: 30242130, PMCID: PMC6231134, DOI: 10.1074/jbc.ra118.003908.Peer-Reviewed Original ResearchConceptsActin-binding regionZO-2Apical surfaceF-actinOrganization of microvilliCortical F-actinZonula occludens-1F-actin disruptionZO-1 interactionCultured epithelial cellsMembrane trafficGUK domainApical specializationsApical epithelial surfacePDZ1 domainPolarized epitheliumEpithelial organizationActomyosin contractionApical structuresProtein ZO-1Tissue organizationActomyosin functionDevelopmental stagesProtein zonula occludens-1Direct interaction