2008
Regulation of blood vessel patterning and branching
Eichmann A. Regulation of blood vessel patterning and branching. The FASEB Journal 2008, 22: 391.2-391.2. DOI: 10.1096/fasebj.22.1_supplement.391.2.Peer-Reviewed Original ResearchMatrix-bound vascular endothelial growth factorVertebrate vascular systemBlood vessel patterningAxon guidance cue netrin-1Endothelial tip cellsAxonal growth conesVessel morphogenesisVessel patterningGuidance cue netrin-1Tip cellsSpecialized endothelial cellsEndothelial cellsNegative regulatorPathological angiogenesisGrowth conesUNC5B receptorDelta-like4Vessel branchingGrowth factorBranched networkVascular endothelial growth factorNetrin-1Endothelial growth factorVascular systemCellsVasculogenesis and Angiogenesis in Development
Eichmann A, Bouvrée K, Pardanaud L. Vasculogenesis and Angiogenesis in Development. 2008, 31-45. DOI: 10.1007/978-3-540-33177-3_2.Peer-Reviewed Original Research
2007
The Notch ligand Delta‐like 4 (Dll4) negatively regulates endothelial tip cell formation and vessel branching
Suchting S, Freitas C, del Toro R, le Noble F, Benedito R, Breant C, Duarte A, Eichmann A. The Notch ligand Delta‐like 4 (Dll4) negatively regulates endothelial tip cell formation and vessel branching. The FASEB Journal 2007, 21: a15-a15. DOI: 10.1096/fasebj.21.5.a15-a.Peer-Reviewed Original ResearchTip cell formationEndothelial tip cell formationTip cellsCell formationNovel negative regulatorCell marker genesEndothelial tip cellsLigand Delta-like 4Severe vascular abnormalitiesVessel branchingDelta-like 4Notch ligand Delta-like 4Embryonic lethalExpression of Dll4Vascular network formationTransmembrane ligandsNotch receptorsMarker genesNotch signalingNegative regulatorAngiogenic sproutingVEGF stimulationVEGF receptor 2Filopodia extensionGenetic backgroundMolecular mechanisms controling vessel branching and morphogenesis
Eichmann A. Molecular mechanisms controling vessel branching and morphogenesis. The FASEB Journal 2007, 21: a197-a197. DOI: 10.1096/fasebj.21.5.a197-b.Peer-Reviewed Original ResearchMatrix-bound vascular endothelial growth factorVertebrate vascular systemAxon guidance cue netrin-1Endothelial tip cellsVessel branchingAxonal growth conesVessel morphogenesisGuidance cue netrin-1Tip cellsSpecialized endothelial cellsEndothelial cellsNegative regulatorMolecular mechanismsPathological angiogenesisGrowth conesUNC5B receptorMorphogenesisDelta-like4Growth factorBranched networkVascular endothelial growth factorNetrin-1Vascular systemEndothelial growth factorCellsThe Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching
Suchting S, Freitas C, le Noble F, Benedito R, Bréant C, Duarte A, Eichmann A. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 3225-3230. PMID: 17296941, PMCID: PMC1805603, DOI: 10.1073/pnas.0611177104.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmyloid Precursor Protein SecretasesAnimalsCalcium-Binding ProteinsEndothelium, VascularGamma-Aminobutyric AcidImmunohistochemistryIn Situ HybridizationIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceMice, Mutant StrainsReceptors, Vascular Endothelial Growth FactorRetinal VesselsSignal TransductionTriglyceridesVascular Endothelial Growth Factor AConceptsTip cell formationEndothelial tip cell formationTip cellsNotch ligand DeltaCell formationCell marker genesEndothelial tip cellsVessel branchingLigand DeltaExpression of Dll4Vascular network formationTransmembrane ligandsNotch receptorsMarker genesNegative regulatorAngiogenic sproutingVEGF receptor 2VEGF stimulationFilopodia extensionGamma-secretase inhibitorsGrowth factor VEGFVascular sproutingPharmacological inhibitionDll4Heterozygous deletion
2004
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
Lu X, le Noble F, Yuan L, Jiang Q, de Lafarge B, Sugiyama D, Bréant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2004, 432: 179-186. PMID: 15510105, DOI: 10.1038/nature03080.Peer-Reviewed Original ResearchConceptsNetrin receptor UNC5BEndothelial tip cell filopodiaTip cell filopodiaReceptor UNC5BEndothelial tip cellsVascular systemNetrin-1aTip cellsEndothelial cellsProper wiringAxon guidanceCell filopodiaNetrin receptorsGuidance eventsFilopodial retractionMorphogenesisUNC5BVessel branchingAberrant extensionAnatomical similaritiesNetrin-1CellsZebrafishGenesGuidance function