2012
ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway
Larrivée B, Prahst C, Gordon E, del Toro R, Mathivet T, Duarte A, Simons M, Eichmann A. ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway. Developmental Cell 2012, 22: 489-500. PMID: 22421041, PMCID: PMC4047762, DOI: 10.1016/j.devcel.2012.02.005.Peer-Reviewed Original ResearchMeSH KeywordsActivin Receptors, Type IActivin Receptors, Type IIAnimalsArteriovenous MalformationsBasic Helix-Loop-Helix Transcription FactorsCell Cycle ProteinsDipeptidesDisease Models, AnimalGrowth Differentiation Factor 2Growth Differentiation FactorsHumansMiceMice, Inbred C57BLNeovascularization, PhysiologicReceptors, NotchRepressor ProteinsRetinaSignal TransductionSmad ProteinsTelangiectasia, Hereditary HemorrhagicVascular Endothelial Growth FactorsConceptsActivin receptor-like kinase 1Hereditary hemorrhagic telangiectasiaArteriovenous malformationsActivation of ALK1Receptor-like kinase 1Notch pathwayVascular lesionsHemorrhagic telangiectasiaPostnatal developmentInhibits angiogenesisNotch inhibitionTip cell formationReceptor familyAngiogenesisHypervascularizationALK1Kinase 1Cell formationEndothelial sproutingPatients
2011
Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B
Koch AW, Mathivet T, Larrivée B, Tong RK, Kowalski J, Pibouin-Fragner L, Bouvrée K, Stawicki S, Nicholes K, Rathore N, Scales SJ, Luis E, del Toro R, Freitas C, Bréant C, Michaud A, Corvol P, Thomas JL, Wu Y, Peale F, Watts RJ, Tessier-Lavigne M, Bagri A, Eichmann A. Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B. Developmental Cell 2011, 20: 33-46. PMID: 21238923, DOI: 10.1016/j.devcel.2010.12.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BlockingBlood VesselsCapillary PermeabilityEnzyme ActivationHumansLigandsMiceModels, BiologicalNeovascularization, PathologicNerve Tissue ProteinsNetrin ReceptorsProtein BindingReceptors, Cell SurfaceReceptors, ImmunologicRetinal VesselsSignal TransductionSrc-Family KinasesSus scrofaVascular Endothelial Growth Factor AConceptsProtein-protein interaction screenVascular endothelial growth factorFunction-blocking monoclonal antibodiesInteraction screenNovel functionGuidance receptorsExtracellular domainNetrin receptorsReceptor familyVessel integrityReceptor interactionInhibits angiogenesisRobo4Unexpected interactionsGrowth factorEndothelial cellsUNC5BVascular integrityEndothelial growth factorAngiogenesisIncreases angiogenesisReceptorsMonoclonal antibodiesIntegrityProtein