2007
Activation of the UNC5B receptor by Netrin‐1 inhibits neovascularization
Larrivée B, Freitas C, Trombe M, Lv X, DeLafarge B, Yuan L, Bouvrée K, Breant C, Bono F, Autiero M, Claes F, Carmeliet P, Tessier‐Lavigne M, Eichmann A. Activation of the UNC5B receptor by Netrin‐1 inhibits neovascularization. The FASEB Journal 2007, 21: a746-a746. DOI: 10.1096/fasebj.21.6.a746-b.Peer-Reviewed Original ResearchNetrin receptor UNC5BEmbryonic vascular patterningFull-length receptorPostnatal vascular developmentPostnatal mouse retinaVascular patterningPotential anti-angiogenic targetCell repulsionAnti-angiogenic targetVascular developmentNetrin-1 stimulationPathological angiogenesisAortic ringsReceptor UNC5BUNC5B receptorUNC5BMouse retinaReceptor activationAxonal growthNetrin-1Tumor angiogenesisTumor modelInhibits neovascularizationAngiogenesisNeovascularization
2004
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
Lu X, le Noble F, Yuan L, Jiang Q, de Lafarge B, Sugiyama D, Bréant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2004, 432: 179-186. PMID: 15510105, DOI: 10.1038/nature03080.Peer-Reviewed Original ResearchConceptsNetrin receptor UNC5BEndothelial tip cell filopodiaTip cell filopodiaReceptor UNC5BEndothelial tip cellsVascular systemNetrin-1aTip cellsEndothelial cellsProper wiringAxon guidanceCell filopodiaNetrin receptorsGuidance eventsFilopodial retractionMorphogenesisUNC5BVessel branchingAberrant extensionAnatomical similaritiesNetrin-1CellsZebrafishGenesGuidance function