2014
An Adenosine Receptor-Krüppel-like Factor 4 Protein Axis Inhibits Adipogenesis*
Eisenstein A, Carroll S, Johnston-Cox H, Farb M, Gokce N, Ravid K. An Adenosine Receptor-Krüppel-like Factor 4 Protein Axis Inhibits Adipogenesis*. Journal Of Biological Chemistry 2014, 289: 21071-21081. PMID: 24928509, PMCID: PMC4110311, DOI: 10.1074/jbc.m114.566406.Peer-Reviewed Original ResearchConceptsKruppel-like factor 4Regulator of stem cell maintenanceRegulator of adipocyte differentiationStem cell maintenanceInhibit differentiationRegulator of adipogenesisAdenosine receptorsKnockdown of KLF4Adipose tissue of obese subjectsAdipose tissue developmentExtracellular ligandsA2B adenosine receptorsKruppel-like factor 4 expressionCell maintenanceExpression of Kruppel-like factor 4Signaling cascadesSignaling moleculesAdipocyte differentiationAdipose biologyStromal vascular cellsTissue developmentAdipocyte progenitorsInhibit adipogenesisObese subjectsA2bAR activation
2013
G Protein‐Coupled Receptors and Adipogenesis: A Focus on Adenosine Receptors
Eisenstein A, Ravid K. G Protein‐Coupled Receptors and Adipogenesis: A Focus on Adenosine Receptors. Journal Of Cellular Physiology 2013, 229: 414-421. PMID: 24114647, PMCID: PMC4362544, DOI: 10.1002/jcp.24473.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsAdenosine receptorsExtracellular signalsAdenosine signalingObesity epidemicMetabolic consequencesDevelopment of therapeuticsBlood flowDownstream messengersReceptorsTranscriptional eventsAdipose tissueMature adipocytesAdipocyte differentiationCellular differentiationMetabolic homeostasisAdenosineCoupled receptorsAdipocytesPhysiological outcomesDifferentiation processExcess nutrientsRegulation functionAdipogenesisDifferentiationA2b adenosine receptor regulation of adipocyte precursor fate and lineage determination: identification of a novel link to the stem cell factor KLF4
Eisenstein A, Ravid K. A2b adenosine receptor regulation of adipocyte precursor fate and lineage determination: identification of a novel link to the stem cell factor KLF4. The FASEB Journal 2013, 27: 599.1-599.1. DOI: 10.1096/fasebj.27.1_supplement.599.1.Peer-Reviewed Original ResearchIn vivo BrdU labelingA2BAR KO miceBay 60-6583A2B adenosine receptorsStem cell factorWild type miceAdipocyte differentiationHigh-fat diet feedingActivate adenylyl cyclaseA2BAR signalingAssociated with cellular proliferationFat diet feedingAdenosine signalingKO miceType miceSpecific agonistsStromal vascular fractionStem cell fateCell factorAdenosine receptorsInhibited adipocyte differentiationPrecursor proliferationA2BARAdenylyl cyclaseMesenchymal stem cells