2015
The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases
Eisenstein A, Patterson S, Ravid K. The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases. Journal Of Cellular Physiology 2015, 230: 2891-2897. PMID: 25975415, PMCID: PMC4811601, DOI: 10.1002/jcp.25043.Peer-Reviewed Original Research
2014
An Adenosine Receptor-Krüppel-like Factor 4 Protein Axis Inhibits Adipogenesis*
Eisenstein A, Carroll S, Johnston-Cox H, Farb M, Gokce N, Ravid K. An Adenosine Receptor-Krüppel-like Factor 4 Protein Axis Inhibits Adipogenesis*. Journal Of Biological Chemistry 2014, 289: 21071-21081. PMID: 24928509, PMCID: PMC4110311, DOI: 10.1074/jbc.m114.566406.Peer-Reviewed Original ResearchConceptsKruppel-like factor 4Regulator of stem cell maintenanceRegulator of adipocyte differentiationStem cell maintenanceInhibit differentiationRegulator of adipogenesisAdenosine receptorsKnockdown of KLF4Adipose tissue of obese subjectsAdipose tissue developmentExtracellular ligandsA2B adenosine receptorsKruppel-like factor 4 expressionCell maintenanceExpression of Kruppel-like factor 4Signaling cascadesSignaling moleculesAdipocyte differentiationAdipose biologyStromal vascular cellsTissue developmentAdipocyte progenitorsInhibit adipogenesisObese subjectsA2bAR activationThe Macrophage A2b Adenosine Receptor Regulates Tissue Insulin Sensitivity
Johnston-Cox H, Eisenstein A, Koupenova M, Carroll S, Ravid K. The Macrophage A2b Adenosine Receptor Regulates Tissue Insulin Sensitivity. PLOS ONE 2014, 9: e98775. PMID: 24892847, PMCID: PMC4043770, DOI: 10.1371/journal.pone.0098775.Peer-Reviewed Original ResearchConceptsInsulin resistanceControl miceLevel of control miceHFD-induced insulin resistanceA2B adenosine receptorsRelease of inflammatory cytokinesHigh-fat diet (HFD)-induced type 2 diabetesInsulin receptor 2Cyclic adenosine monophosphateTissue insulin sensitivityRegulation of inflammationTissue insulin resistanceTissue insulin signalingType 2 diabetesTransgenic mouse modelA2BAR expressionA2BAR signalingInsulin signalingReceptor influenceTissue inflammationNull backgroundNull miceReceptor 2Adenosine receptorsLiver inflammation
2013
G Protein‐Coupled Receptors and Adipogenesis: A Focus on Adenosine Receptors
Eisenstein A, Ravid K. G Protein‐Coupled Receptors and Adipogenesis: A Focus on Adenosine Receptors. Journal Of Cellular Physiology 2013, 229: 414-421. PMID: 24114647, PMCID: PMC4362544, DOI: 10.1002/jcp.24473.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsAdenosine receptorsExtracellular signalsAdenosine signalingObesity epidemicMetabolic consequencesDevelopment of therapeuticsBlood flowDownstream messengersReceptorsTranscriptional eventsAdipose tissueMature adipocytesAdipocyte differentiationCellular differentiationMetabolic homeostasisAdenosineCoupled receptorsAdipocytesPhysiological outcomesDifferentiation processExcess nutrientsRegulation functionAdipogenesisDifferentiationA2b adenosine receptor regulation of adipocyte precursor fate and lineage determination: identification of a novel link to the stem cell factor KLF4
Eisenstein A, Ravid K. A2b adenosine receptor regulation of adipocyte precursor fate and lineage determination: identification of a novel link to the stem cell factor KLF4. The FASEB Journal 2013, 27: 599.1-599.1. DOI: 10.1096/fasebj.27.1_supplement.599.1.Peer-Reviewed Original ResearchIn vivo BrdU labelingA2BAR KO miceBay 60-6583A2B adenosine receptorsStem cell factorWild type miceAdipocyte differentiationHigh-fat diet feedingActivate adenylyl cyclaseA2BAR signalingAssociated with cellular proliferationFat diet feedingAdenosine signalingKO miceType miceSpecific agonistsStromal vascular fractionStem cell fateCell factorAdenosine receptorsInhibited adipocyte differentiationPrecursor proliferationA2BARAdenylyl cyclaseMesenchymal stem cells
2012
A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors
Sun Y, Duan Y, Eisenstein A, Hu W, Quintana A, Lam W, Wang Y, Wu Z, Ravid K, Huang P. A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors. Journal Of Cell Science 2012, 125: 4507-4517. PMID: 22767505, PMCID: PMC3500865, DOI: 10.1242/jcs.105023.Peer-Reviewed Original ResearchConceptsExpression of anti-NFkB activationC-terminusEctopic expressionP105 proteinsAdenosine receptorsTranscription factor NFKB1A(2B) adenosine receptorsInhibited NFkB activationPolyubiquitylationSpecific sitesA2B adenosine receptorsLigand activationNFkB pathwayP105Interleukin (IL)-10Nuclear factor kappa BProtein levelsTumor necrosis factorPro-inflammatory cytokinesFactor kappa BRegulationIL-12PathwayTNF-a