2011
Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner
King IL, Fortier A, Tighe M, Dibble J, Watts GF, Veerapen N, Haberman AM, Besra GS, Mohrs M, Brenner MB, Leadbetter EA. Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner. Nature Immunology 2011, 13: 44-50. PMID: 22120118, PMCID: PMC3833037, DOI: 10.1038/ni.2172.Peer-Reviewed Original Research
2010
Differential Localization of Effector and Memory CD8 T Cell Subsets in Lymphoid Organs during Acute Viral Infection
Jung YW, Rutishauser RL, Joshi NS, Haberman AM, Kaech SM. Differential Localization of Effector and Memory CD8 T Cell Subsets in Lymphoid Organs during Acute Viral Infection. The Journal Of Immunology 2010, 185: 5315-5325. PMID: 20921525, PMCID: PMC4267692, DOI: 10.4049/jimmunol.1001948.Peer-Reviewed Original ResearchConceptsT cell zonesKiller cell lectin-like receptor G1T cellsRed pulpCell zoneViral infectionMemory CD8 T cell subsetsEffector CD8 T cellsCD8 T cell subsetsLymphocytic choriomeningitis virus infectionTranscription factor T-betT cells persistAcute viral infectionCD8 T cellsMemory T cellsT cell subsetsCytokine IL-7B lymphocyte-induced maturation protein-1Long-term survivalMaturation protein-1Receptor G1Cell subsetsLymphoid organsChemokine receptorsChemokines CCL19
2007
New markers for murine memory B cells that define mutated and unmutated subsets
Anderson SM, Tomayko MM, Ahuja A, Haberman AM, Shlomchik MJ. New markers for murine memory B cells that define mutated and unmutated subsets. Journal Of Experimental Medicine 2007, 204: 2103-2114. PMID: 17698588, PMCID: PMC2118690, DOI: 10.1084/jem.20062571.Peer-Reviewed Original ResearchConceptsMemory B cellsMurine memory B cellsB cellsAntigen-specific memory B cellsMemory B cell subsetsMemory B cell markersNon-Tg miceExpression of CD80B-cell markersB cell subsetsTransgenic mouse modelCell subsetsSplenic folliclesMemory compartmentMouse modelNaive precursorsMutation statusCell markersUnmutated subsetDefinitive markerMemory cellsAnatomic heterogeneityNew markersCell number
2003
Reassessing the function of immune-complex retention by follicular dendritic cells
Haberman AM, Shlomchik MJ. Reassessing the function of immune-complex retention by follicular dendritic cells. Nature Reviews Immunology 2003, 3: 757-764. PMID: 12949499, DOI: 10.1038/nri1178.Peer-Reviewed Original ResearchConceptsFollicular dendritic cellsDendritic cellsImmune complexesSurface of FDCsMemory B-cell maintenanceMemory B cell developmentB cell maintenanceGerminal center B cellsGerminal center developmentB cell proliferationAffinity maturationB cell recognitionB cellsB cell developmentPotential roleNon-specific mannerCellsClose associationMaturation
2002
Very Low Affinity B Cells Form Germinal Centers, Become Memory B Cells, and Participate in Secondary Immune Responses When Higher Affinity Competition Is Reduced
Dal Porto JM, Haberman AM, Kelsoe G, Shlomchik MJ. Very Low Affinity B Cells Form Germinal Centers, Become Memory B Cells, and Participate in Secondary Immune Responses When Higher Affinity Competition Is Reduced. Journal Of Experimental Medicine 2002, 195: 1215-1221. PMID: 11994427, PMCID: PMC2193705, DOI: 10.1084/jem.20011550.Peer-Reviewed Original ResearchConceptsAntibody-forming cellsMemory B cellsImmune responseB cellsB cell antigen receptorT cell-dependent immune responsesCell-dependent immune responsesLow-affinity B cellsH chain transgenic miceMemory B cell populationsHigh affinity competitionSecondary immune responseSpecific immune responseAntigen-specific cellsGerminal center responseSuch B cellsB cell populationsH chain transgeneLate primary responseGerminal centersTransgenic miceCenter responseCell antigen receptorAntigen receptorPrimary response
2000
A B-cell receptor-specific selection step governs immature to mature B cell differentiation
Levine M, Haberman A, Sant'Angelo D, Hannum L, Cancro M, Janeway C, Shlomchik M. A B-cell receptor-specific selection step governs immature to mature B cell differentiation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 2743-2748. PMID: 10688906, PMCID: PMC16000, DOI: 10.1073/pnas.050552997.Peer-Reviewed Original ResearchConceptsImmature B cellsMature B cellsB cell receptor repertoirePositive selection eventsB cell differentiationReceptor repertoireSelection eventsCell differentiationB cellsChain pairsCell receptor repertoirePeripheral B cellsReceptor specificityTime cellsMajor forceCell fractionCellsAdaptive immune responsesRepertoireConventional B cellsAvailable repertoireSelection stepImmune responseB cell fractionsSignificant skewing