2014
Dynamic Expression of BCL6 in Murine Conventional Dendritic Cells during In Vivo Development and Activation
Zhang TT, Liu D, Calabro S, Eisenbarth SC, Cattoretti G, Haberman AM. Dynamic Expression of BCL6 in Murine Conventional Dendritic Cells during In Vivo Development and Activation. PLOS ONE 2014, 9: e101208. PMID: 24979752, PMCID: PMC4076320, DOI: 10.1371/journal.pone.0101208.Peer-Reviewed Original ResearchConceptsProtein levelsBCL6 levelsMurine conventional dendritic cellsFollicular helper T cellsCommon DC precursorsFunction of Bcl6BCL6 protein levelsConventional dendritic cellsHelper T cellsSecondary lymphoid organsGerminal center B cellsElevated protein levelsBone marrow hematopoietic stem cellsTranscriptional repressor BCL6Marrow hematopoietic stem cellsAdjuvant inoculationCDC subsetsSplenic cDCsDendritic cellsLPS injectionDC precursorsLymphoid organsMicrobial stimuliT cellsKi-67
2012
Spirochete antigens persist near cartilage after murine Lyme borreliosis therapy
Bockenstedt LK, Gonzalez DG, Haberman AM, Belperron AA. Spirochete antigens persist near cartilage after murine Lyme borreliosis therapy. Journal Of Clinical Investigation 2012, 122: 2652-2660. PMID: 22728937, PMCID: PMC3386809, DOI: 10.1172/jci58813.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Bacterial AgentsAntigens, BacterialArthritis, InfectiousBacterial LoadBorrelia burgdorferiCartilageCeftriaxoneDoxycyclineEar, ExternalFemaleFluorescence Recovery After PhotobleachingGreen Fluorescent ProteinsJoint CapsuleLyme DiseaseMiceMice, Inbred C3HMice, Inbred C57BLMice, KnockoutMicroscopy, Fluorescence, MultiphotonMyeloid Differentiation Factor 88PatellaRecombinant ProteinsConceptsNaive miceAntibiotic treatmentIntravital microscopyAntibiotic-refractory Lyme arthritisLyme diseaseTNF-α productionBorrelia burgdorferi antigensB. burgdorferi antigensSpirochete antigenTLR responsivenessInflammatory arthritisAntibiotic therapyLyme arthritisWT miceMusculoskeletal symptomsAntigens persistSlow resolutionImmunodeficient miceMouse modelTissue transplantsPathogen burdenSpirochete DNAInfectious spirochetesLyme borreliosisMice