2021
C–X–C Chemokine Receptor Type 4‑Targeted Imaging in Glioblastoma Multiforme Using 64Cu-Radiolabeled Ultrasmall Gold Nanoclusters
Zhang X, Detering L, Sultan D, Heo G, Luehmann H, Taylor S, Choksi A, Rubin J, Liu Y. C–X–C Chemokine Receptor Type 4‑Targeted Imaging in Glioblastoma Multiforme Using 64Cu-Radiolabeled Ultrasmall Gold Nanoclusters. ACS Applied Bio Materials 2021, 5: 235-242. PMID: 35014818, DOI: 10.1021/acsabm.1c01056.Peer-Reviewed Original ResearchConceptsC-X-C chemokine receptor 4C-X-CGlioblastoma multiformePositron emission tomographyAggressive primary malignant brain cancerAssociated with poor patient survivalDifficult-to-treat cancersPET/computed tomography imagingPoor patient survivalChemokine receptor 4GBM mouse modelPositron emission tomography imagingEffective drug deliveryGBM imagingMalignant brain cancerPrimary malignant brain cancerOverall survivalMultimodal treatmentDrug deliveryPatient survivalPoor prognosisTreatment responseTargeted PET imagingRenal clearanceMouse model
2019
Assessment of Copper Nanoclusters for Accurate in Vivo Tumor Imaging and Potential for Translation
Heo G, Zhao Y, Sultan D, Zhang X, Detering L, Luehmann H, Zhang X, Li R, Choksi A, Sharp S, Levingston S, Primeau T, Reichert D, Sun G, Razani B, Li S, Weilbaecher K, Dehdashti F, Wooley K, Liu Y. Assessment of Copper Nanoclusters for Accurate in Vivo Tumor Imaging and Potential for Translation. ACS Applied Materials & Interfaces 2019, 11: 19669-19678. PMID: 31074257, PMCID: PMC7811435, DOI: 10.1021/acsami.8b22752.Peer-Reviewed Original ResearchConceptsTriple negative breast cancerPatient-derived xenograft mouse modelsNegative breast cancerDetection of malignancyXenograft mouse modelImaging-guided treatmentCopper nanoclustersHuman TNBC tissuesPotential of nanoparticlesBreast cancerMinimal toxicityTumor retentionMouse modelTNBC tissuesTumor biomarkersOff-target effectsClinical translationCancer theranosticsClinical settingTranslational potentialTumor imagingInaccurate diagnosisCancer imagingCancerPotential toxicity