C–X–C Chemokine Receptor Type 4‑Targeted Imaging in Glioblastoma Multiforme Using 64Cu-Radiolabeled Ultrasmall Gold Nanoclusters
Zhang X, Detering L, Sultan D, Heo G, Luehmann H, Taylor S, Choksi A, Rubin J, Liu Y. C–X–C Chemokine Receptor Type 4‑Targeted Imaging in Glioblastoma Multiforme Using 64Cu-Radiolabeled Ultrasmall Gold Nanoclusters. ACS Applied Bio Materials 2021, 5: 235-242. PMID: 35014818, DOI: 10.1021/acsabm.1c01056.Peer-Reviewed Original ResearchConceptsC-X-C chemokine receptor 4C-X-CGlioblastoma multiformePositron emission tomographyAggressive primary malignant brain cancerAssociated with poor patient survivalDifficult-to-treat cancersPET/computed tomography imagingPoor patient survivalChemokine receptor 4GBM mouse modelPositron emission tomography imagingEffective drug deliveryGBM imagingMalignant brain cancerPrimary malignant brain cancerOverall survivalMultimodal treatmentDrug deliveryPatient survivalPoor prognosisTreatment responseTargeted PET imagingRenal clearanceMouse model