Assessment of Copper Nanoclusters for Accurate in Vivo Tumor Imaging and Potential for Translation
Heo G, Zhao Y, Sultan D, Zhang X, Detering L, Luehmann H, Zhang X, Li R, Choksi A, Sharp S, Levingston S, Primeau T, Reichert D, Sun G, Razani B, Li S, Weilbaecher K, Dehdashti F, Wooley K, Liu Y. Assessment of Copper Nanoclusters for Accurate in Vivo Tumor Imaging and Potential for Translation. ACS Applied Materials & Interfaces 2019, 11: 19669-19678. PMID: 31074257, PMCID: PMC7811435, DOI: 10.1021/acsami.8b22752.Peer-Reviewed Original ResearchConceptsTriple negative breast cancerPatient-derived xenograft mouse modelsNegative breast cancerDetection of malignancyXenograft mouse modelImaging-guided treatmentCopper nanoclustersHuman TNBC tissuesPotential of nanoparticlesBreast cancerMinimal toxicityTumor retentionMouse modelTNBC tissuesTumor biomarkersOff-target effectsClinical translationCancer theranosticsClinical settingTranslational potentialTumor imagingInaccurate diagnosisCancer imagingCancerPotential toxicity