2024
Consistent evidence that brain serotonin 2A receptor binding is positively associated with personality-based risk markers of depression.
Høgsted E, Beliveau V, Ozenne B, Madsen M, Svarer C, Dam V, Johansen A, Fisher P, Knudsen G, Frokjaer V, Sankar A. Consistent evidence that brain serotonin 2A receptor binding is positively associated with personality-based risk markers of depression. The British Journal Of Psychiatry 2024, 1-7. PMID: 39632615, DOI: 10.1192/bjp.2024.143.Peer-Reviewed Original ResearchFacets of neuroticismCortisol awakening responseHPA axis functionR bindingReduce neuroticismAxis functionPositron emission tomographyNEO Personality InventoryNEO-PI-RAssessment of neuroticismSerotonin 2A receptorMarkers of depressionTreatment of depressionPersonality InventoryMood symptomsAwakening responseNeuroticismPositive associationLatent variable modelsSelf-consciousnessDepressionReceptor bindingNovel interventionsPsilocybinFindings prompt consideration
2023
Association between brain serotonin 4 receptor binding and reactivity to emotional faces in depressed and healthy individuals
Sankar A, Ozenne B, Dam V, Svarer C, Jørgensen M, Miskowiak K, Frokjaer V, Knudsen G, Fisher P. Association between brain serotonin 4 receptor binding and reactivity to emotional faces in depressed and healthy individuals. Translational Psychiatry 2023, 13: 165. PMID: 37169780, PMCID: PMC10175268, DOI: 10.1038/s41398-023-02440-3.Peer-Reviewed Original ResearchConceptsResponses to emotional facesFunctional magnetic resonance imagingEmotional facesNeural responsesNeural responses to emotional stimuliEmotional face-matching taskNeural processing of emotionResponses to emotional stimuliPositron emission tomographyEmotional processing biasesFace-matching taskProcessing of emotionsHealthy controlsAntidepressant treatmentBrain serotonergicProcessing biasesDepressive disorderEmotional processingEmotional stimuliSerotonergic signalingMDDMatching taskBrain functionLatent variable modelsDepression status