Association between brain serotonin 4 receptor binding and reactivity to emotional faces in depressed and healthy individuals
Sankar A, Ozenne B, Dam V, Svarer C, Jørgensen M, Miskowiak K, Frokjaer V, Knudsen G, Fisher P. Association between brain serotonin 4 receptor binding and reactivity to emotional faces in depressed and healthy individuals. Translational Psychiatry 2023, 13: 165. PMID: 37169780, PMCID: PMC10175268, DOI: 10.1038/s41398-023-02440-3.Peer-Reviewed Original ResearchConceptsResponses to emotional facesFunctional magnetic resonance imagingEmotional facesNeural responsesNeural responses to emotional stimuliEmotional face-matching taskNeural processing of emotionResponses to emotional stimuliPositron emission tomographyEmotional processing biasesFace-matching taskProcessing of emotionsHealthy controlsAntidepressant treatmentBrain serotonergicProcessing biasesDepressive disorderEmotional processingEmotional stimuliSerotonergic signalingMDDMatching taskBrain functionLatent variable modelsDepression statusSerotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction
Köhler-Forsberg K, Dam V, Ozenne B, Sankar A, Beliveau V, Landman E, Larsen S, Poulsen A, Ip C, Jørgensen A, Meyer M, Stenbæk D, Eiberg H, Madsen J, Svarer C, Jørgensen M, Frokjaer V, Knudsen G. Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction. JAMA Psychiatry 2023, 80: 296-304. PMID: 36753296, PMCID: PMC9909578, DOI: 10.1001/jamapsychiatry.2022.4539.Peer-Reviewed Original ResearchConceptsMemory dysfunctionUntreated MDDDepressive disorderReceptor bindingHealthy controlsModerate to severe depressive episodePositron emission tomographyMajor depressive disorderSevere depressive episodeVerbal memory performanceNeurobiological signatureDepressive episodeVerbal memoryMemory performanceCognitive domainsDepression trialsMDDDepressive stateBrain bindingCognitive testsCognitive functionGroup differencesAssociated with improved learningSerotonin-4Adult participantsAssociation of neurocognitive function with psychiatric hospitalization and socio-demographic conditions in individuals with bipolar and major depressive disorders
Sankar A, Ziersen S, Ozenne B, Beaman E, Dam V, Fisher P, Knudsen G, Kessing L, Frokjaer V, Miskowiak K. Association of neurocognitive function with psychiatric hospitalization and socio-demographic conditions in individuals with bipolar and major depressive disorders. EClinicalMedicine 2023, 58: 101927. PMID: 37007740, PMCID: PMC10050788, DOI: 10.1016/j.eclinm.2023.101927.Peer-Reviewed Original ResearchSocio-demographic conditionsPsychiatric hospitalAffective disordersNeurocognitive impairmentDepressive disorderExecutive functionVerbal memoryNeurocognitive functionNational population-based registersPopulation-based registersAssociation of neurocognitionVerbal memory domainSocio-demographic indicatorsStudies of neurocognitionClinically significant impairmentFuture hospitalsDepression severityMemory domainCox regression modelsIllness durationNeurocognitive assessmentEmployment outcomesSecondary outcomesSignificant impairmentStudy inclusionDeep phenotyping towards precision psychiatry of first-episode depression — the Brain Drugs-Depression cohort
Jensen K, Dam V, Ganz M, Fisher P, Ip C, Sankar A, Marstrand-Joergensen M, Ozenne B, Osler M, Penninx B, Pinborg L, Frokjaer V, Knudsen G, Jørgensen M. Deep phenotyping towards precision psychiatry of first-episode depression — the Brain Drugs-Depression cohort. BMC Psychiatry 2023, 23: 151. PMID: 36894940, PMCID: PMC9999625, DOI: 10.1186/s12888-023-04618-x.Peer-Reviewed Original ResearchConceptsQuick Inventory of Depressive SymptomatologyFirst-episode depressionTreatment packageFirst-episode MDD patientsInventory of Depressive SymptomatologyBackgroundMajor depressive disorderSecond-line antidepressantsHeterogeneous brain disordersMarkers of treatment responseMedication side effectsMDD patientsDepressive disorderDepression severityDepressive symptomatologyPrecision psychiatrySymptom ChecklistClinical outcomesNeuroimaging dataBrain positron emission tomographyPublic outpatient clinicsDisability ScalePositron emission tomographyBrain disordersEffect of treatment choiceDepression